UniProtKB - Q9JHQ5 (LZTL1_MOUSE)
Protein
Leucine zipper transcription factor-like protein 1
Gene
Lztfl1
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.2 Publications
GO - Molecular functioni
- identical protein binding Source: MGI
- protein-containing complex binding Source: UniProtKB
GO - Biological processi
- negative regulation of protein localization to ciliary membrane Source: MGI
- negative regulation of protein localization to cilium Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-5620922, BBSome-mediated cargo-targeting to cilium |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine zipper transcription factor-like protein 1 |
Gene namesi | Name:Lztfl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1934860, Lztfl1 |
Subcellular locationi
Other locations
- Cytoplasm 2 Publications
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318760 | 1 – 299 | Leucine zipper transcription factor-like protein 1Add BLAST | 299 |
Proteomic databases
EPDi | Q9JHQ5 |
jPOSTi | Q9JHQ5 |
MaxQBi | Q9JHQ5 |
PaxDbi | Q9JHQ5 |
PRIDEi | Q9JHQ5 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00458573 Q9JHQ5 |
PTM databases
iPTMneti | Q9JHQ5 |
PhosphoSitePlusi | Q9JHQ5 |
Expressioni
Tissue specificityi
Highly expressed in testis. Expressed in brain, cerebellum, eye, heart, kidney, liver, lung and trachea. In small intestine, graded expression along the crypt-villus axis with high levels in the villus apex and lower levels in the crypt stem cells (at protein level). Not expressed in skeletal muscle and white adipose tissue.4 Publications
Inductioni
In hippocampus, up-regulated by exercise training.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025245, Expressed in testis and 286 other tissues |
ExpressionAtlasi | Q9JHQ5, baseline and differential |
Genevisiblei | Q9JHQ5, MM |
Interactioni
Subunit structurei
Self-associates.
Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.
Binary interactionsi
Q9JHQ5
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] from Homo sapiens. | 2 | EBI-6142879,EBI-491549 |
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 220275, 5 interactors |
IntActi | Q9JHQ5, 3 interactors |
STRINGi | 10090.ENSMUSP00000026274 |
Miscellaneous databases
RNActi | Q9JHQ5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 145 – 299 | Interaction with BSS9By similarityAdd BLAST | 155 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 96 – 299 | Sequence analysisAdd BLAST | 204 |
Sequence similaritiesi
Belongs to the LZTFL1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRGB, Eukaryota |
GeneTreei | ENSGT00390000016415 |
HOGENOMi | CLU_083519_0_0_1 |
InParanoidi | Q9JHQ5 |
OMAi | SQAEKWH |
OrthoDBi | 1107668at2759 |
PhylomeDBi | Q9JHQ5 |
TreeFami | TF329023 |
Family and domain databases
InterProi | View protein in InterPro IPR026157, LZTFL1 |
PANTHERi | PTHR21635, PTHR21635, 1 hit |
Pfami | View protein in Pfam PF15294, Leu_zip, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9JHQ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK DSRLVEETFT
60 70 80 90 100
IDEVSEVLNG LQAVVHSEVE SELINTAYTN VLLLRQLFSQ AEKWYLKLQT
110 120 130 140 150
DISELENREL LEQVAEFEKA EFVSSSKKPI IDITKPKLVP INEGGTTELL
160 170 180 190 200
NKEILRLQQE NEKLKSRLKT IEIQAVNALD EKSKLERVLQ DLQLDQENQQ
210 220 230 240 250
DLLKAQDLDD LENTVATLRS EFQKTLNDKT ENQKSLEENL AAAKHDLLRV
260 270 280 290
QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6VTH5 | F6VTH5_MOUSE | Leucine zipper transcription factor... | Lztfl1 | 235 | Annotation score: | ||
F6VG18 | F6VG18_MOUSE | Leucine zipper transcription factor... | Lztfl1 | 218 | Annotation score: | ||
A0A1L1SSX7 | A0A1L1SSX7_MOUSE | Leucine zipper transcription factor... | Lztfl1 | 290 | Annotation score: | ||
A0A1L1ST13 | A0A1L1ST13_MOUSE | Leucine zipper transcription factor... | Lztfl1 | 207 | Annotation score: | ||
E9Q9P1 | E9Q9P1_MOUSE | Leucine zipper transcription factor... | Lztfl1 | 134 | Annotation score: |
Sequence cautioni
The sequence BAC26556 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 280 | K → E in BAC26556 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 283 | D → G in BAC30817 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297352 mRNA Translation: CAB95845.1 AK029671 mRNA Translation: BAC26556.1 Frameshift. AK041091 mRNA Translation: BAC30817.1 AK046515 mRNA Translation: BAC32764.1 AK054003 mRNA Translation: BAC35616.1 AK145263 mRNA Translation: BAE26331.1 AK157770 mRNA Translation: BAE34189.1 BC026840 mRNA Translation: AAH26840.1 BC098224 mRNA Translation: AAH98224.1 |
CCDSi | CCDS40818.1 |
RefSeqi | NP_201579.1, NM_033322.2 |
Genome annotation databases
Ensembli | ENSMUST00000026274; ENSMUSP00000026274; ENSMUSG00000025245 |
GeneIDi | 93730 |
KEGGi | mmu:93730 |
UCSCi | uc009sgm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297352 mRNA Translation: CAB95845.1 AK029671 mRNA Translation: BAC26556.1 Frameshift. AK041091 mRNA Translation: BAC30817.1 AK046515 mRNA Translation: BAC32764.1 AK054003 mRNA Translation: BAC35616.1 AK145263 mRNA Translation: BAE26331.1 AK157770 mRNA Translation: BAE34189.1 BC026840 mRNA Translation: AAH26840.1 BC098224 mRNA Translation: AAH98224.1 |
CCDSi | CCDS40818.1 |
RefSeqi | NP_201579.1, NM_033322.2 |
3D structure databases
SMRi | Q9JHQ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 220275, 5 interactors |
IntActi | Q9JHQ5, 3 interactors |
STRINGi | 10090.ENSMUSP00000026274 |
PTM databases
iPTMneti | Q9JHQ5 |
PhosphoSitePlusi | Q9JHQ5 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00458573 Q9JHQ5 |
Proteomic databases
EPDi | Q9JHQ5 |
jPOSTi | Q9JHQ5 |
MaxQBi | Q9JHQ5 |
PaxDbi | Q9JHQ5 |
PRIDEi | Q9JHQ5 |
Protocols and materials databases
Antibodypediai | 29604, 248 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026274; ENSMUSP00000026274; ENSMUSG00000025245 |
GeneIDi | 93730 |
KEGGi | mmu:93730 |
UCSCi | uc009sgm.1, mouse |
Organism-specific databases
CTDi | 54585 |
MGIi | MGI:1934860, Lztfl1 |
Phylogenomic databases
eggNOGi | ENOG502QRGB, Eukaryota |
GeneTreei | ENSGT00390000016415 |
HOGENOMi | CLU_083519_0_0_1 |
InParanoidi | Q9JHQ5 |
OMAi | SQAEKWH |
OrthoDBi | 1107668at2759 |
PhylomeDBi | Q9JHQ5 |
TreeFami | TF329023 |
Enzyme and pathway databases
Reactomei | R-MMU-5620922, BBSome-mediated cargo-targeting to cilium |
Miscellaneous databases
BioGRID-ORCSi | 93730, 2 hits in 17 CRISPR screens |
ChiTaRSi | Lztfl1, mouse |
PROi | PR:Q9JHQ5 |
RNActi | Q9JHQ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025245, Expressed in testis and 286 other tissues |
ExpressionAtlasi | Q9JHQ5, baseline and differential |
Genevisiblei | Q9JHQ5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR026157, LZTFL1 |
PANTHERi | PTHR21635, PTHR21635, 1 hit |
Pfami | View protein in Pfam PF15294, Leu_zip, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LZTL1_MOUSE | |
Accessioni | Q9JHQ5Primary (citable) accession number: Q9JHQ5 Secondary accession number(s): Q8BRX8, Q8CDS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families