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Protein

Serine/threonine-protein kinase 19

Gene

Stk19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to be a protein kinase.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarityNote: Divalent metal cations. Has a preference for Mn2+.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 19 (EC:2.7.11.1)
Alternative name(s):
Protein RP1
Gene namesi
Name:Stk19
Synonyms:Rp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1860085 Stk19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722761 – 254Serine/threonine-protein kinase 19Add BLAST254

Proteomic databases

EPDiQ9JHN8
MaxQBiQ9JHN8
PaxDbiQ9JHN8
PRIDEiQ9JHN8

PTM databases

PhosphoSitePlusiQ9JHN8

Expressioni

Gene expression databases

BgeeiENSMUSG00000061207 Expressed in 24 organ(s), highest expression level in brain
CleanExiMM_STK19
ExpressionAtlasiQ9JHN8 baseline and differential
GenevisibleiQ9JHN8 MM

Interactioni

Subunit structurei

The N-terminus interacts with BAG1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076686

Structurei

3D structure databases

ProteinModelPortaliQ9JHN8
SMRiQ9JHN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STK19 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA
GeneTreeiENSGT00390000018295
HOGENOMiHOG000272639
HOVERGENiHBG056144
InParanoidiQ9JHN8
KOiK08880
OMAiREPVRHC
OrthoDBiEOG091G0OOT
PhylomeDBiQ9JHN8
TreeFamiTF105332

Family and domain databases

InterProiView protein in InterPro
IPR018865 Ser/Thr_kinase_19
PANTHERiPTHR15243 PTHR15243, 1 hit
PfamiView protein in Pfam
PF10494 Stk19, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JHN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRKRRLLAS EAFGVKRRRA PGPVRADPLR TRAGSAREAI EELVKLFPRG
60 70 80 90 100
LFEDALPPIA LRSQVYSLVP DRTVADLQLK ELQELGEIRI IQLGFDLDAH
110 120 130 140 150
GIVFTEDYRT RVLKACDGRP CAGAVQKFLA SVLPACGDLS FQQDQMTQTY
160 170 180 190 200
GFRDPEITQL VNAGVLTVRD AGSWWLAVPG AGRFIKCFVK GRQAVLSMVR
210 220 230 240 250
KAKYRELALS ELLGRRAPLA VRLGLAYHVH DLIGAQLVDC VPTTSGTLLR

LPDT
Length:254
Mass (Da):28,104
Last modified:October 18, 2001 - v2
Checksum:i9F7BEAEC06DCC9D2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CHD9F7CHD9_MOUSE
Serine/threonine-protein kinase 19
Stk19
179Annotation score:
F6SFN2F6SFN2_MOUSE
Serine/threonine-protein kinase 19
Stk19
107Annotation score:
F6XXB9F6XXB9_MOUSE
Serine/threonine-protein kinase 19
Stk19
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049850 Genomic DNA Translation: AAC05280.1
BC022681 mRNA Translation: AAH22681.1
AF099934 mRNA Translation: AAF26174.1
CCDSiCCDS28659.1
RefSeqiNP_062315.1, NM_019442.3
UniGeneiMm.440064

Genome annotation databases

EnsembliENSMUST00000077477; ENSMUSP00000076686; ENSMUSG00000061207
GeneIDi54402
KEGGimmu:54402
UCSCiuc008cdq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049850 Genomic DNA Translation: AAC05280.1
BC022681 mRNA Translation: AAH22681.1
AF099934 mRNA Translation: AAF26174.1
CCDSiCCDS28659.1
RefSeqiNP_062315.1, NM_019442.3
UniGeneiMm.440064

3D structure databases

ProteinModelPortaliQ9JHN8
SMRiQ9JHN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076686

PTM databases

PhosphoSitePlusiQ9JHN8

Proteomic databases

EPDiQ9JHN8
MaxQBiQ9JHN8
PaxDbiQ9JHN8
PRIDEiQ9JHN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077477; ENSMUSP00000076686; ENSMUSG00000061207
GeneIDi54402
KEGGimmu:54402
UCSCiuc008cdq.1 mouse

Organism-specific databases

CTDi8859
MGIiMGI:1860085 Stk19

Phylogenomic databases

eggNOGiENOG410IEVV Eukaryota
ENOG410YGZ8 LUCA
GeneTreeiENSGT00390000018295
HOGENOMiHOG000272639
HOVERGENiHBG056144
InParanoidiQ9JHN8
KOiK08880
OMAiREPVRHC
OrthoDBiEOG091G0OOT
PhylomeDBiQ9JHN8
TreeFamiTF105332

Miscellaneous databases

ChiTaRSiCyp4a10 mouse
PROiPR:Q9JHN8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061207 Expressed in 24 organ(s), highest expression level in brain
CleanExiMM_STK19
ExpressionAtlasiQ9JHN8 baseline and differential
GenevisibleiQ9JHN8 MM

Family and domain databases

InterProiView protein in InterPro
IPR018865 Ser/Thr_kinase_19
PANTHERiPTHR15243 PTHR15243, 1 hit
PfamiView protein in Pfam
PF10494 Stk19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK19_MOUSE
AccessioniPrimary (citable) accession number: Q9JHN8
Secondary accession number(s): O70347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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