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Protein

Linker for activation of T-cells family member 2

Gene

Lat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity, Mast cell degranulation

Enzyme and pathway databases

ReactomeiR-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization

Names & Taxonomyi

Protein namesi
Recommended name:
Linker for activation of T-cells family member 2
Alternative name(s):
Linker for activation of B-cells
Membrane-associated adapter molecule
Non-T-cell activation linker
Williams-Beuren syndrome chromosomal region 15 protein homolog
Gene namesi
Name:Lat2
Synonyms:Lab, Ntal, Wbscr15, Wbscr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926479 Lat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 203CytoplasmicSequence analysisAdd BLAST176

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit normal T-cell, B-cell and mast cell development and normal humoral response, but have hyperresponsive mast cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000833351 – 203Linker for activation of T-cells family member 2Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi26S-palmitoyl cysteineBy similarity1
Lipidationi29S-palmitoyl cysteineBy similarity1
Modified residuei59PhosphotyrosineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei139PhosphotyrosineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1
Modified residuei192PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9JHL0
PeptideAtlasiQ9JHL0
PRIDEiQ9JHL0

PTM databases

iPTMnetiQ9JHL0
PhosphoSitePlusiQ9JHL0
SwissPalmiQ9JHL0

Expressioni

Tissue specificityi

Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level).3 Publications

Developmental stagei

Hardly expressed in pro-B and pre-B cells. Moderately expressed in immature B-cells, mature B-cells and plasma cells. Highly expressed in transitional B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000040751 Expressed in 87 organ(s), highest expression level in spleen
CleanExiMM_LAT2
ExpressionAtlasiQ9JHL0 baseline and differential
GenevisibleiQ9JHL0 MM

Interactioni

Subunit structurei

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ9JHL0
STRINGi10090.ENSMUSP00000046900

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZVX Eukaryota
ENOG4111816 LUCA
GeneTreeiENSGT00390000006821
HOGENOMiHOG000113868
HOVERGENiHBG082063
InParanoidiQ9JHL0
OMAiEDQQSFT
OrthoDBiEOG091G0M21
PhylomeDBiQ9JHL0
TreeFamiTF336203

Family and domain databases

InterProiView protein in InterPro
IPR031428 LAT2
PANTHERiPTHR15646 PTHR15646, 1 hit
PfamiView protein in Pfam
PF15703 LAT2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD332876 PD332876, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JHL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAELELLWP VSGLLLLLLG ATAWLCVHCS RPGVKRNEKI YEQRNRQENA
60 70 80 90 100
QSSAAAQTYS LARQVWPGPQ MDTAPNKSFE RKNKMLFSHL EGPESPRYQN
110 120 130 140 150
FYKGSNQEPD AAYVDPIPTN YYNWGCFQKP SEDDDSNSYE NVLVCKPSTP
160 170 180 190 200
ESGVEDFEDY QNSVSIHQWR ESKRTMGAPM SLSGSPDEEP DYVNGDVAAA

ENI
Length:203
Mass (Da):22,876
Last modified:October 1, 2000 - v1
Checksum:i1B21A87D8FBAE097
GO
Isoform 2 (identifier: Q9JHL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-103: Missing.

Show »
Length:191
Mass (Da):21,409
Checksum:i1E874CA4D55A01E6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU43A0A0J9YU43_MOUSE
Linker for activation of T-cells fa...
Lat2
119Annotation score:
A0A0J9YVD5A0A0J9YVD5_MOUSE
Linker for activation of T-cells fa...
Lat2
115Annotation score:
A0A0J9YV28A0A0J9YV28_MOUSE
Linker for activation of T-cells fa...
Lat2
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114V → E in BAE22256 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01664692 – 103Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257136 mRNA Translation: AAF91353.1
AF139987 Genomic DNA Translation: AAF75558.1
AF139987 Genomic DNA Translation: AAF75559.1
AY190024 mRNA Translation: AAO63156.1
AF289664 Genomic DNA Translation: AAF99331.1
AK134721 mRNA Translation: BAE22256.1
AK138953 mRNA Translation: BAE23833.1
AK143533 mRNA Translation: BAE25422.1
AK162321 mRNA Translation: BAE36852.1
BC005804 mRNA Translation: AAH05804.1
CCDSiCCDS39311.1 [Q9JHL0-2]
CCDS39312.1 [Q9JHL0-1]
RefSeqiNP_064428.1, NM_020044.3 [Q9JHL0-1]
NP_075253.2, NM_022964.4 [Q9JHL0-2]
XP_006504513.1, XM_006504450.2 [Q9JHL0-1]
XP_006504514.1, XM_006504451.3 [Q9JHL0-1]
XP_006504515.1, XM_006504452.2 [Q9JHL0-2]
UniGeneiMm.391375

Genome annotation databases

EnsembliENSMUST00000036362; ENSMUSP00000046900; ENSMUSG00000040751 [Q9JHL0-1]
ENSMUST00000077636; ENSMUSP00000076824; ENSMUSG00000040751 [Q9JHL0-2]
ENSMUST00000200998; ENSMUSP00000143977; ENSMUSG00000040751 [Q9JHL0-1]
GeneIDi56743
KEGGimmu:56743
UCSCiuc008zwm.2 mouse [Q9JHL0-1]
uc008zwo.2 mouse [Q9JHL0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257136 mRNA Translation: AAF91353.1
AF139987 Genomic DNA Translation: AAF75558.1
AF139987 Genomic DNA Translation: AAF75559.1
AY190024 mRNA Translation: AAO63156.1
AF289664 Genomic DNA Translation: AAF99331.1
AK134721 mRNA Translation: BAE22256.1
AK138953 mRNA Translation: BAE23833.1
AK143533 mRNA Translation: BAE25422.1
AK162321 mRNA Translation: BAE36852.1
BC005804 mRNA Translation: AAH05804.1
CCDSiCCDS39311.1 [Q9JHL0-2]
CCDS39312.1 [Q9JHL0-1]
RefSeqiNP_064428.1, NM_020044.3 [Q9JHL0-1]
NP_075253.2, NM_022964.4 [Q9JHL0-2]
XP_006504513.1, XM_006504450.2 [Q9JHL0-1]
XP_006504514.1, XM_006504451.3 [Q9JHL0-1]
XP_006504515.1, XM_006504452.2 [Q9JHL0-2]
UniGeneiMm.391375

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9JHL0
STRINGi10090.ENSMUSP00000046900

PTM databases

iPTMnetiQ9JHL0
PhosphoSitePlusiQ9JHL0
SwissPalmiQ9JHL0

Proteomic databases

PaxDbiQ9JHL0
PeptideAtlasiQ9JHL0
PRIDEiQ9JHL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036362; ENSMUSP00000046900; ENSMUSG00000040751 [Q9JHL0-1]
ENSMUST00000077636; ENSMUSP00000076824; ENSMUSG00000040751 [Q9JHL0-2]
ENSMUST00000200998; ENSMUSP00000143977; ENSMUSG00000040751 [Q9JHL0-1]
GeneIDi56743
KEGGimmu:56743
UCSCiuc008zwm.2 mouse [Q9JHL0-1]
uc008zwo.2 mouse [Q9JHL0-2]

Organism-specific databases

CTDi7462
MGIiMGI:1926479 Lat2

Phylogenomic databases

eggNOGiENOG410IZVX Eukaryota
ENOG4111816 LUCA
GeneTreeiENSGT00390000006821
HOGENOMiHOG000113868
HOVERGENiHBG082063
InParanoidiQ9JHL0
OMAiEDQQSFT
OrthoDBiEOG091G0M21
PhylomeDBiQ9JHL0
TreeFamiTF336203

Enzyme and pathway databases

ReactomeiR-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization

Miscellaneous databases

PROiPR:Q9JHL0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040751 Expressed in 87 organ(s), highest expression level in spleen
CleanExiMM_LAT2
ExpressionAtlasiQ9JHL0 baseline and differential
GenevisibleiQ9JHL0 MM

Family and domain databases

InterProiView protein in InterPro
IPR031428 LAT2
PANTHERiPTHR15646 PTHR15646, 1 hit
PfamiView protein in Pfam
PF15703 LAT2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD332876 PD332876, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTAL_MOUSE
AccessioniPrimary (citable) accession number: Q9JHL0
Secondary accession number(s): Q3UYF6, Q9JJ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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