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Entry version 172 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Caspase 9, isoform CRA_a

Gene

Casp9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseARBA annotation
Biological processApoptosisARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-111458, Formation of apoptosome
R-RNO-111459, Activation of caspases through apoptosome-mediated cleavage
R-RNO-168638, NOD1/2 Signaling Pathway
R-RNO-198323, AKT phosphorylates targets in the cytosol
R-RNO-418889, Caspase activation via Dependence Receptors in the absence of ligand
R-RNO-9627069, Regulation of the apoptosome activity

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C14.010

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Caspase 9, isoform CRA_aImported
Submitted name:
Caspase-9Imported
Submitted name:
Caspase-9 long isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Casp9Imported
Synonyms:RNCASP9Imported
ORF Names:rCG_30964Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
61867, Casp9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

ZymogenARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9JHK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012944, Expressed in brain and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JHK1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JHK1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9JHK1

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017972

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JHK1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92CARDInterPro annotationAdd BLAST92
Domaini197 – 329CASPASE_P20InterPro annotationAdd BLAST133
Domaini369 – 453CASPASE_P10InterPro annotationAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036904_5_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLSHGCQ

Database of Orthologous Groups

More...
OrthoDBi
1092723at2759

TreeFam database of animal gene trees

More...
TreeFami
TF102023

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08326, CARD_CASP9, 1 hit
cd00032, CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR042147, CARD_CASP9
IPR033171, Caspase-9
IPR029030, Caspase-like_dom_sf
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR011029, DEATH-like_dom_sf
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A

The PANTHER Classification System

More...
PANTHERi
PTHR10454, PTHR10454, 1 hit
PTHR10454:SF157, PTHR10454:SF157, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00376, IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00114, CARD, 1 hit
SM00115, CASc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF52129, SSF52129, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JHK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEADRQLLR RCRVRLVREL QVAELWDALL SRELFTRDMI EDIQRAGSGS
60 70 80 90 100
RRDQARQLVI DLETRGRQAL PRFISCLEDT GQGSLASFLQ SSGQAAKQDP
110 120 130 140 150
EAVTPLDHLV PVVLGPMGLK SKEQKVVKLD PSQPALGNLT PVVLGPEELW
160 170 180 190 200
PTRLRPEVLT PETPRPVDIG SGRAHDVCTP GKIERHADMA YTLDSDPCGH
210 220 230 240 250
CLIINNVNFC PSSGLSTRIG SHVDCEKLQH RFCWLRFMVE VKNDLTAKKM
260 270 280 290 300
VTALMEMAHR DHRALDCFVV VILSHGCQAS HLQFPGAVYG TDGCSVSIER
310 320 330 340 350
IVNIFNGTGC PSLGGKPKLF FIQACGGEQK DHGFEVAFTS SQDKAFDSDS
360 370 380 390 400
EPDAVPYQEG PRTLDQLDAV SSLPTPSDIL VSYSTFPGFV SWRDKKSGSW
410 420 430 440 450
YIETLDGVLE QWARSEDLQS LLLRVANAVS EKGVYKQIPG CFNFLRKKLF

FKTS
Length:454
Mass (Da):50,400
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i501623B29E6ED6FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q920G4Q920G4_RAT
Caspase 9
Casp9 rCG_30964
177Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K3V0A0A0G2K3V0_RAT
Caspase 9
Casp9
229Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07050305 Genomic DNA No translation available.
AF271996 mRNA Translation: AAF76217.1
AF262319 mRNA Translation: AAF85658.1
AF286006 mRNA Translation: AAF99705.1
AY027667 mRNA Translation: AAK26235.1
AF308469 mRNA Translation: AAK35159.1
CH473968 Genomic DNA Translation: EDL81013.1

NCBI Reference Sequences

More...
RefSeqi
NP_113820.1, NM_031632.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000017972; ENSRNOP00000017972; ENSRNOG00000012944
ENSRNOT00000085378; ENSRNOP00000072710; ENSRNOG00000012944

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:58918

UCSC genome browser

More...
UCSCi
RGD:61867, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050305 Genomic DNA No translation available.
AF271996 mRNA Translation: AAF76217.1
AF262319 mRNA Translation: AAF85658.1
AF286006 mRNA Translation: AAF99705.1
AY027667 mRNA Translation: AAK26235.1
AF308469 mRNA Translation: AAK35159.1
CH473968 Genomic DNA Translation: EDL81013.1
RefSeqiNP_113820.1, NM_031632.1

3D structure databases

SMRiQ9JHK1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JHK1, 2 interactors
MINTiQ9JHK1
STRINGi10116.ENSRNOP00000017972

Protein family/group databases

MEROPSiC14.010

Proteomic databases

PRIDEiQ9JHK1

Genome annotation databases

EnsembliENSRNOT00000017972; ENSRNOP00000017972; ENSRNOG00000012944
ENSRNOT00000085378; ENSRNOP00000072710; ENSRNOG00000012944
GeneIDi58918
KEGGirno:58918
UCSCiRGD:61867, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
842
RGDi61867, Casp9

Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00940000159698
HOGENOMiCLU_036904_5_0_1
OMAiVLSHGCQ
OrthoDBi1092723at2759
TreeFamiTF102023

Enzyme and pathway databases

ReactomeiR-RNO-111458, Formation of apoptosome
R-RNO-111459, Activation of caspases through apoptosome-mediated cleavage
R-RNO-168638, NOD1/2 Signaling Pathway
R-RNO-198323, AKT phosphorylates targets in the cytosol
R-RNO-418889, Caspase activation via Dependence Receptors in the absence of ligand
R-RNO-9627069, Regulation of the apoptosome activity

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9JHK1

Gene expression databases

BgeeiENSRNOG00000012944, Expressed in brain and 21 other tissues
ExpressionAtlasiQ9JHK1, baseline and differential

Family and domain databases

CDDicd08326, CARD_CASP9, 1 hit
cd00032, CASc, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR042147, CARD_CASP9
IPR033171, Caspase-9
IPR029030, Caspase-like_dom_sf
IPR033139, Caspase_cys_AS
IPR016129, Caspase_his_AS
IPR011029, DEATH-like_dom_sf
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A
PANTHERiPTHR10454, PTHR10454, 1 hit
PTHR10454:SF157, PTHR10454:SF157, 1 hit
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PRINTSiPR00376, IL1BCENZYME
SMARTiView protein in SMART
SM00114, CARD, 1 hit
SM00115, CASc, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF52129, SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit
PS01122, CASPASE_CYS, 1 hit
PS01121, CASPASE_HIS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9JHK1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JHK1
Secondary accession number(s): F1M776
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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