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Protein

5-hydroxytryptamine receptor 3B

Gene

Htr3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-112314 Neurotransmitter receptors and postsynaptic signal transmission

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3B
Short name:
5-HT3-B
Short name:
5-HT3B
Alternative name(s):
Serotonin receptor 3B
Gene namesi
Name:Htr3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1861899 Htr3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 238ExtracellularSequence analysisAdd BLAST217
Transmembranei239 – 259Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini260 – 264CytoplasmicSequence analysis5
Transmembranei265 – 282Helical; Name=2Sequence analysisAdd BLAST18
Topological domaini283 – 292ExtracellularSequence analysis10
Transmembranei293 – 313Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini314 – 410CytoplasmicSequence analysisAdd BLAST97
Transmembranei411 – 431Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini432 – 437ExtracellularSequence analysis6

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3781
GuidetoPHARMACOLOGYi374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031229022 – 4375-hydroxytryptamine receptor 3BAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 165By similarity
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylation is required for membrane localization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JHJ5
PRIDEiQ9JHJ5

PTM databases

iPTMnetiQ9JHJ5
PhosphoSitePlusiQ9JHJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000008590
CleanExiMM_HTR3B
GenevisibleiQ9JHJ5 MM

Interactioni

Subunit structurei

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi208209, 1 interactor
ComplexPortaliCPX-275 5-hydroxytryptamine-3A/B receptor complex
IntActiQ9JHJ5, 1 interactor
STRINGi10090.ENSMUSP00000008734

Chemistry databases

BindingDBiQ9JHJ5

Structurei

3D structure databases

ProteinModelPortaliQ9JHJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 409HA-stretchAdd BLAST33

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000241519
HOVERGENiHBG106638
InParanoidiQ9JHJ5
KOiK04819
OMAiQIQFNVV
OrthoDBiEOG091G08WI
PhylomeDBiQ9JHJ5
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR008132 5HT3_rcpt
IPR008134 5HT3_rcpt_B
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01710 5HT3BRECEPTR
PR01708 5HT3RECEPTOR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLWSCLLV AVVGILGTAT PQPGNSSLHR LTRQLLQQYH KEVRPVYNWA
60 70 80 90 100
EATTVYLDLC VHAVLDVDVQ NQKLKTSVWY REVWNDEFLS WNSSLFDEIQ
110 120 130 140 150
EISLPLSALW APDIIINEFV DVERSPDLPY VYVNSSGTIR NHKPIQVVSA
160 170 180 190 200
CSLQTYAFPF DIQNCSLTFN SILHTVEDID LGFLRNREDI ENDKRAFMND
210 220 230 240 250
SEWQLLSVSS TYHIRQSSAG DFAQIRFNVV IRRCPLAYVV SLLIPSIFLM
260 270 280 290 300
LVDLGSFYLP PNCRARIVFK TNVLVGYTVF RVNMSDEVPR SAGCTPLIGV
310 320 330 340 350
FFTVCMALLV LSLSKSILLI KFLYEERHSG QERPLMCLQG DSDAEESRLY
360 370 380 390 400
LGAPRADVTE SPVHQEHRVP SDTLKDFWFQ FRSINNSLRT RDQIHQKEVE
410 420 430
WLAILYRFDQ LLFRIYLAVL GLYTVTLCSL WALWSRM
Length:437
Mass (Da):50,321
Last modified:October 1, 2000 - v1
Checksum:i60019008AF23F0FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155045 mRNA Translation: AAF73284.1
AF155052
, AF155046, AF155047, AF155048, AF155049, AF155050, AF155051 Genomic DNA Translation: AAF73285.1
AK085213 mRNA Translation: BAC39391.1
BC046990 mRNA Translation: AAH46990.1
CCDSiCCDS23160.1
RefSeqiNP_064670.1, NM_020274.4
UniGeneiMm.117131

Genome annotation databases

EnsembliENSMUST00000008734; ENSMUSP00000008734; ENSMUSG00000008590
GeneIDi57014
KEGGimmu:57014
UCSCiuc012gsr.1 mouse

Similar proteinsi

Entry informationi

Entry namei5HT3B_MOUSE
AccessioniPrimary (citable) accession number: Q9JHJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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