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Protein

Receptor activity-modifying protein 2

Gene

Ramp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 2
Gene namesi
Name:Ramp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61872 Ramp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 152ExtracellularSequence analysisAdd BLAST107
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 182CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi52

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_000003017446 – 182Receptor activity-modifying protein 2Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 106By similarity
Disulfide bondi91 ↔ 138By similarity
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JHJ1
PRIDEiQ9JHJ1

PTM databases

iPTMnetiQ9JHJ1
PhosphoSitePlusiQ9JHJ1

Expressioni

Gene expression databases

BgeeiENSRNOG00000020415 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiQ9JHJ1 baseline and differential
GenevisibleiQ9JHJ1 RN

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-244 Adrenomedullin receptor AM1 complex
CPX-247 Amylin receptor 2 complex
STRINGi10116.ENSRNOP00000043210

Structurei

3D structure databases

ProteinModelPortaliQ9JHJ1
SMRiQ9JHJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYPR Eukaryota
ENOG4112A9G LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000230963
HOVERGENiHBG067366
InParanoidiQ9JHJ1
KOiK08448
OMAiGAVLKPH
OrthoDBiEOG091G0RMZ
PhylomeDBiQ9JHJ1

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JHJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLRVERAP GGSQLAVTSA QRPAALRLPP LLLLLLLLLL GAVSTSPESL
60 70 80 90 100
NQSHPTEDSL LSKGKMEDYE TNVLPCWYYY KTSMDSVKDW CNWTLISRYY
110 120 130 140 150
SNLRYCLEYE ADKFGLGFPN PLAESIILEA HLIHFANCSL VQPTFSDPPE
160 170 180
DVLLAMIIAP ICLIPFLVTL VVWRSKDGDA QA
Length:182
Mass (Da):20,300
Last modified:October 1, 2000 - v1
Checksum:i6A506053D7EE0748
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5YW89A5YW89_RAT
Receptor activity modifying protein...
Ramp2
156Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042888 mRNA Translation: BAB03505.1
AB030943 mRNA Translation: BAA94426.1
AF181551 mRNA Translation: AAG09435.1
PIRiJC7236
RefSeqiNP_113834.1, NM_031646.1
UniGeneiRn.107168

Genome annotation databases

EnsembliENSRNOT00000043953; ENSRNOP00000043210; ENSRNOG00000020415
GeneIDi58966
KEGGirno:58966
UCSCiRGD:61872 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042888 mRNA Translation: BAB03505.1
AB030943 mRNA Translation: BAA94426.1
AF181551 mRNA Translation: AAG09435.1
PIRiJC7236
RefSeqiNP_113834.1, NM_031646.1
UniGeneiRn.107168

3D structure databases

ProteinModelPortaliQ9JHJ1
SMRiQ9JHJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-244 Adrenomedullin receptor AM1 complex
CPX-247 Amylin receptor 2 complex
STRINGi10116.ENSRNOP00000043210

Chemistry databases

GuidetoPHARMACOLOGYi52

PTM databases

iPTMnetiQ9JHJ1
PhosphoSitePlusiQ9JHJ1

Proteomic databases

PaxDbiQ9JHJ1
PRIDEiQ9JHJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043953; ENSRNOP00000043210; ENSRNOG00000020415
GeneIDi58966
KEGGirno:58966
UCSCiRGD:61872 rat

Organism-specific databases

CTDi10266
RGDi61872 Ramp2

Phylogenomic databases

eggNOGiENOG410IYPR Eukaryota
ENOG4112A9G LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000230963
HOVERGENiHBG067366
InParanoidiQ9JHJ1
KOiK08448
OMAiGAVLKPH
OrthoDBiEOG091G0RMZ
PhylomeDBiQ9JHJ1

Enzyme and pathway databases

ReactomeiR-RNO-419812 Calcitonin-like ligand receptors

Miscellaneous databases

PROiPR:Q9JHJ1

Gene expression databases

BgeeiENSRNOG00000020415 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiQ9JHJ1 baseline and differential
GenevisibleiQ9JHJ1 RN

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP2_RAT
AccessioniPrimary (citable) accession number: Q9JHJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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