Solute carrier family 40 member 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ferrous iron transmembrane transporter activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization."
    Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J.
    Science 306:2090-2093(2004) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2."
    De Domenico I., Lo E., Ward D.M., Kaplan J.
    Proc. Natl. Acad. Sci. U.S.A. 106:3800-3805(2009) [PubMed] [Europe PMC] [Abstract]
• iron ion transmembrane transporter activity Source: BHF-UCLInferred from direct assayⁱ
  • "Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization."
    Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J.
    Science 306:2090-2093(2004) [PubMed] [Europe PMC] [Abstract]
• peptide hormone binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization."
    Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J.
    Science 306:2090-2093(2004) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular iron ion homeostasis Source: MGI
• endothelium development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice."
    Mok H., Mendoza M., Prchal J.T., Balogh P., Schumacher A.
    Development 131:4871-4881(2004) [PubMed] [Europe PMC] [Abstract]
• iron ion export across plasma membrane Source: ARUK-UCLInferred from direct assayⁱ
  • "Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization."
    Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., Kaplan J.
    Science 306:2090-2093(2004) [PubMed] [Europe PMC] [Abstract]
• iron ion homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Brain and retinal ferroportin 1 dysregulation in polycythaemia mice."
    Iacovelli J., Mlodnicka A.E., Veldman P., Ying G.S., Dunaief J.L., Schumacher A.
    Brain Res. 1289:85-95(2009) [PubMed] [Europe PMC] [Abstract]
• iron ion transmembrane transport Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts."
    Zhang D.L., Senecal T., Ghosh M.C., Ollivierre-Wilson H., Tu T., Rouault T.A.
    Blood 118:2868-2877(2011) [PubMed] [Europe PMC] [Abstract]
• iron ion transport Source: MGIInferred from direct assayⁱ
  • "Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization."
    Haile D.J.
    Cytogenet. Cell Genet. 88:328-329(2000) [PubMed] [Europe PMC] [Abstract]
• lymphocyte homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Otx2 regulates subtype specification and neurogenesis in the midbrain."
    Vernay B., Koch M., Vaccarino F., Briscoe J., Simeone A., Kageyama R., Ang S.L.
    J. Neurosci. 25:4856-4867(2005) [PubMed] [Europe PMC] [Abstract]
• multicellular organismal iron ion homeostasis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice."
    Mok H., Jelinek J., Pai S., Cattanach B.M., Prchal J.T., Youssoufian H., Schumacher A.
    Development 131:1859-1868(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice."
    Mok H., Mendoza M., Prchal J.T., Balogh P., Schumacher A.
    Development 131:4871-4881(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice."
    De Domenico I., Zhang T.Y., Koening C.L., Branch R.W., London N., Lo E., Daynes R.A., Kushner J.P., Li D., Ward D.M., Kaplan J.
    J. Clin. Invest. 120:2395-2405(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription from RNA polymerase II promoter in response to iron Source: MGIInferred from direct assayⁱ
  • "HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis."
    White C., Yuan X., Schmidt P.J., Bresciani E., Samuel T.K., Campagna D., Hall C., Bishop K., Calicchio M.L., Lapierre A., Ward D.M., Liu P., Fleming M.D., Hamza I.
    Cell Metab. 17:261-270(2013) [PubMed] [Europe PMC] [Abstract]
• spleen development Source: MGIInferred from mutant phenotypeⁱ
  • "Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice."
    Mok H., Mendoza M., Prchal J.T., Balogh P., Schumacher A.
    Development 131:4871-4881(2004) [PubMed] [Europe PMC] [Abstract]
• spleen trabecula formation Source: MGIInferred from mutant phenotypeⁱ
  • "Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice."
    Mok H., Mendoza M., Prchal J.T., Balogh P., Schumacher A.
    Development 131:4871-4881(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2."
    De Domenico I., Lo E., Ward D.M., Kaplan J.
    Proc. Natl. Acad. Sci. U.S.A. 106:3800-3805(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL 
        60         70         80         90        100
VELYGNSLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN 
       110        120        130        140        150
VSVILCGIIL MMVFLHKNEL LTMYHGWVLT VCYILIITIA NIANLASTAT 
       160        170        180        190        200
AITIQRDWIV VVAGENRSRL ADMNATIRRI DQLTNILAPM AVGQIMTFGS 
       210        220        230        240        250
PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK VEESELKQLT 
       260        270        280        290        300
SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 
       310        320        330        340        350
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA 
       360        370        380        390        400
ITGIMGTVAF TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL 
       410        420        430        440        450
SVSPFEDIRS RFVNVEPVSP TTKIPETVFT TEMHMSNMSN VHEMSTKPIP 
       460        470        480        490        500
IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ ENVIESERGI INGVQNSMNY 
       510        520        530        540        550
LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF AQKTLGNQIF 
       560        570
VCGPDEKEVT DENQPNTSVV                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot