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Entry version 152 (25 May 2022)
Sequence version 1 (01 Oct 2000)
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Protein

Solute carrier family 40 member 1

Gene

Slc40a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major iron transporter that plays a key role in balancing cellular and systemic iron levels. Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (PubMed:30213870).

Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (PubMed:16054062).

When iron is in excess hepcidin/HAMP levels increase, resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

During elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface ferroportin/SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi39Iron 1By similarity1
Metal bindingi43Iron 1By similarity1
Metal bindingi326Iron 2By similarity1
Metal bindingi506Iron 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-425410, Metal ion SLC transporters
R-MMU-917937, Iron uptake and transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.100.1.1, the ferroportin (fpn) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 40 member 1
Alternative name(s):
Ferroportin-1
Iron-regulated transporter 1
Metal transporter protein 1
Short name:
MTP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc40a1
Synonyms:Fpn1, Ireg1, Slc11a3, Slc39a1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1315204, Slc40a1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000025993

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23CytoplasmicBy similarityAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 53HelicalBy similarityAdd BLAST30
Topological domaini54 – 57ExtracellularBy similarity4
Transmembranei58 – 84HelicalBy similarityAdd BLAST27
Topological domaini85 – 87CytoplasmicBy similarity3
Transmembranei88 – 118HelicalBy similarityAdd BLAST31
Topological domaini119 – 126ExtracellularBy similarity8
Transmembranei127 – 162HelicalBy similarityAdd BLAST36
Topological domaini163 – 164CytoplasmicBy similarity2
Transmembranei165 – 195HelicalBy similarityAdd BLAST31
Topological domaini196 – 202ExtracellularBy similarity7
Transmembranei203 – 229HelicalBy similarityAdd BLAST27
Topological domaini230 – 306CytoplasmicBy similarityAdd BLAST77
Transmembranei307 – 333HelicalBy similarityAdd BLAST27
Topological domaini334 – 338ExtracellularBy similarity5
Transmembranei339 – 366HelicalBy similarityAdd BLAST28
Topological domaini367 – 368CytoplasmicBy similarity2
Transmembranei369 – 391HelicalBy similarityAdd BLAST23
Topological domaini392 – 452ExtracellularBy similarityAdd BLAST61
Transmembranei453 – 482HelicalBy similarityAdd BLAST30
Topological domaini483 – 487CytoplasmicBy similarity5
Transmembranei488 – 512HelicalBy similarityAdd BLAST25
Topological domaini513 – 515ExtracellularBy similarity3
Transmembranei516 – 541HelicalBy similarityAdd BLAST26
Topological domaini542 – 570CytoplasmicBy similarityAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion mice die prenatallys. These mice cannot transfer iron from the extraembryonic visceral endoderm into the embryo proper, leading to a defect in embryonic growth and consequent death (PubMed:16054062). Erythroid-specific deletion reduces serum iron but increased tissue iron contents (PubMed:30213870).2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4523462

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1194

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913111 – 570Solute carrier family 40 member 1Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by RNF217; leading to proteasomal degradation (PubMed:33895792). Ubiquitination is necessary for its internalization by hepcidin/HAMP (By similarity).By similarity1 Publication

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9JHI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JHI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9JHI9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
256902

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9JHI9, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JHI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JHI9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9JHI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in spleen, liver, kidney, heart and duodenum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025993, Expressed in liver and 290 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JHI9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a complex with STOM.

Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-58649N

Protein interaction database and analysis system

More...
IntActi
Q9JHI9, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027137

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JHI9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9JHI9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JHI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2601, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015143

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020370_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JHI9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVHELEH

Database of Orthologous Groups

More...
OrthoDBi
334057at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JHI9

TreeFam database of animal gene trees

More...
TreeFami
TF313463

Family and domain databases

Conserved Domains Database

More...
CDDi
cd17480, MFS_SLC40A1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009716, Ferroportin-1
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11660, PTHR11660, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06963, FPN1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JHI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL
60 70 80 90 100
VELYGNSLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN
110 120 130 140 150
VSVILCGIIL MMVFLHKNEL LTMYHGWVLT VCYILIITIA NIANLASTAT
160 170 180 190 200
AITIQRDWIV VVAGENRSRL ADMNATIRRI DQLTNILAPM AVGQIMTFGS
210 220 230 240 250
PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK VEESELKQLT
260 270 280 290 300
SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV
310 320 330 340 350
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA
360 370 380 390 400
ITGIMGTVAF TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL
410 420 430 440 450
SVSPFEDIRS RFVNVEPVSP TTKIPETVFT TEMHMSNMSN VHEMSTKPIP
460 470 480 490 500
IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ ENVIESERGI INGVQNSMNY
510 520 530 540 550
LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF AQKTLGNQIF
560 570
VCGPDEKEVT DENQPNTSVV
Length:570
Mass (Da):62,702
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7125CC6171394A0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C5H8V4C5H8V4_MOUSE
Solute carrier family 40 protein
Slc40a1
70Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF215637 mRNA Translation: AAF80987.1
AF216834 Genomic DNA Translation: AAF82036.1
AF226613 mRNA Translation: AAF36696.1
AF231120 mRNA Translation: AAF44329.1
AK008700 mRNA Translation: BAB25840.1
AK032732 mRNA Translation: BAC28001.1
AK083288 mRNA Translation: BAC38844.1
AK144780 mRNA Translation: BAE26063.1
AK147137 mRNA Translation: BAE27707.1
AK159294 mRNA Translation: BAE34969.1
AK159855 mRNA Translation: BAE35431.1
BC003438 mRNA Translation: AAH03438.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14933.1

NCBI Reference Sequences

More...
RefSeqi
NP_058613.2, NM_016917.2
XP_006496200.1, XM_006496137.2
XP_017177198.1, XM_017321709.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:53945

UCSC genome browser

More...
UCSCi
uc007awu.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215637 mRNA Translation: AAF80987.1
AF216834 Genomic DNA Translation: AAF82036.1
AF226613 mRNA Translation: AAF36696.1
AF231120 mRNA Translation: AAF44329.1
AK008700 mRNA Translation: BAB25840.1
AK032732 mRNA Translation: BAC28001.1
AK083288 mRNA Translation: BAC38844.1
AK144780 mRNA Translation: BAE26063.1
AK147137 mRNA Translation: BAE27707.1
AK159294 mRNA Translation: BAE34969.1
AK159855 mRNA Translation: BAE35431.1
BC003438 mRNA Translation: AAH03438.1
CCDSiCCDS14933.1
RefSeqiNP_058613.2, NM_016917.2
XP_006496200.1, XM_006496137.2
XP_017177198.1, XM_017321709.1

3D structure databases

AlphaFoldDBiQ9JHI9
SMRiQ9JHI9
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-58649N
IntActiQ9JHI9, 4 interactors
STRINGi10090.ENSMUSP00000027137

Chemistry databases

ChEMBLiCHEMBL4523462
GuidetoPHARMACOLOGYi1194

Protein family/group databases

TCDBi2.A.100.1.1, the ferroportin (fpn) family

PTM databases

GlyGeniQ9JHI9, 4 sites
iPTMnetiQ9JHI9
PhosphoSitePlusiQ9JHI9
SwissPalmiQ9JHI9

Proteomic databases

MaxQBiQ9JHI9
PaxDbiQ9JHI9
PRIDEiQ9JHI9
ProteomicsDBi256902

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34022, 393 antibodies from 33 providers

The DNASU plasmid repository

More...
DNASUi
53945

Genome annotation databases

EnsembliENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993
GeneIDi53945
KEGGimmu:53945
UCSCiuc007awu.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30061
MGIiMGI:1315204, Slc40a1
VEuPathDBiHostDB:ENSMUSG00000025993

Phylogenomic databases

eggNOGiKOG2601, Eukaryota
GeneTreeiENSGT00390000015143
HOGENOMiCLU_020370_1_1_1
InParanoidiQ9JHI9
OMAiNVHELEH
OrthoDBi334057at2759
PhylomeDBiQ9JHI9
TreeFamiTF313463

Enzyme and pathway databases

ReactomeiR-MMU-425410, Metal ion SLC transporters
R-MMU-917937, Iron uptake and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
53945, 3 hits in 74 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc40a1, mouse

Protein Ontology

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PROi
PR:Q9JHI9
RNActiQ9JHI9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000025993, Expressed in liver and 290 other tissues
GenevisibleiQ9JHI9, MM

Family and domain databases

CDDicd17480, MFS_SLC40A1_like, 1 hit
Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR009716, Ferroportin-1
IPR036259, MFS_trans_sf
PANTHERiPTHR11660, PTHR11660, 1 hit
PfamiView protein in Pfam
PF06963, FPN1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS40A1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JHI9
Secondary accession number(s): Q3UHZ9
, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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