UniProtKB - Q9JHI2 (ADAT1_MOUSE)
Protein
tRNA-specific adenosine deaminase 1
Gene
Adat1
Organism
Mus musculus (Mouse)
Status
Functioni
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.1 Publication
Catalytic activityi
- EC:3.5.4.341 Publication
Cofactori
1D-myo-inositol hexakisphosphateBy similarityNote: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 87 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 89 | Proton donorPROSITE-ProRule annotation | 1 | |
Binding sitei | 93 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 94 | Inositol hexakisphosphateBy similarity | 1 | |
Metal bindingi | 142 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 294 | ZincPROSITE-ProRule annotation | 1 | |
Binding sitei | 297 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 300 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 430 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 466 | Inositol hexakisphosphateBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- tRNA-specific adenosine deaminase activity Source: UniProtKB
GO - Biological processi
- tRNA processing Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | tRNA processing |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA-specific adenosine deaminase 1 (EC:3.5.4.34)Short name: mADAT1 Alternative name(s): tRNA-specific adenosine-37 deaminase |
Gene namesi | Name:Adat1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353631, Adat1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287648 | 1 – 499 | tRNA-specific adenosine deaminase 1Add BLAST | 499 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 191 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9JHI2 |
PaxDbi | Q9JHI2 |
PeptideAtlasi | Q9JHI2 |
PRIDEi | Q9JHI2 |
PTM databases
iPTMneti | Q9JHI2 |
PhosphoSitePlusi | Q9JHI2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031949, Expressed in retina and 187 other tissues |
ExpressionAtlasi | Q9JHI2, baseline and differential |
Genevisiblei | Q9JHI2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034427 |
Miscellaneous databases
RNActi | Q9JHI2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 63 – 498 | A to I editasePROSITE-ProRule annotationAdd BLAST | 436 |
Sequence similaritiesi
Belongs to the ADAT1 family.Curated
Phylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000157942 |
HOGENOMi | CLU_005382_5_2_1 |
InParanoidi | Q9JHI2 |
OMAi | ASWIRNP |
OrthoDBi | 947117at2759 |
PhylomeDBi | Q9JHI2 |
TreeFami | TF315806 |
Family and domain databases
InterProi | View protein in InterPro IPR002466, A_deamin |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9JHI2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWTADEIAQL CYAHYNVRLP KQGKPEPNRE WTLLAAVVKI QASANQACDI
60 70 80 90 100
PEKEVQVTKE VVSMGTGTKC IGQSKMRESG DILNDSHAEI IARRSFQRYL
110 120 130 140 150
LHQLHLAAVL KEDSIFVPGT QRGLWRLRPD LSFVFFSSHT PCGDASIIPM
160 170 180 190 200
LEFEEQPCCP VIRSWANNSP VQETENLEDS KDKRNCEDPA SPVAKKMRLG
210 220 230 240 250
TPARSLSNCV AHHGTQESGP VKPDVSSSDL TKEEPDAANG IASGSFRVVD
260 270 280 290 300
VYRTGAKCVP GETGDLREPG AAYHQVGLLR VKPGRGDRTC SMSCSDKMAR
310 320 330 340 350
WNVLGCQGAL LMHFLEKPIY LSAVVIGKCP YSQEAMRRAL TGRCEETLVL
360 370 380 390 400
PRGFGVQELE IQQSGLLFEQ SRCAVHRKRG DSPGRLVPCG AAISWSAVPQ
410 420 430 440 450
QPLDVTANGF PQGTTKKEIG SPRARSRISK VELFRSFQKL LSSIADDEQP
460 470 480 490
DSIRVTKKLD TYQEYKDAAS AYQEAWGALR RIQPFASWIR NPPDYHQFK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z6J6 | D3Z6J6_MOUSE | tRNA-specific adenosine deaminase 1 | Adat1 | 354 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 201 | T → A in BAE36167 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025580 | 343 – 424 | Missing in isoform 3. CuratedAdd BLAST | 82 | |
Alternative sequenceiVSP_025581 | 455 – 499 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF192375 mRNA Translation: AAF36820.1 AF192374 , AF192367, AF192368, AF192369, AF192370, AF192371, AF192372, AF192373 Genomic DNA Translation: AAF36821.1 AK035614 mRNA Translation: BAC29125.1 AK039699 mRNA Translation: BAC30422.1 AK082399 mRNA Translation: BAC38487.1 AK161044 mRNA Translation: BAE36167.1 BC019976 mRNA Translation: AAH19976.1 |
CCDSi | CCDS22684.1 [Q9JHI2-1] CCDS90464.1 [Q9JHI2-2] |
RefSeqi | NP_038953.1, NM_013925.4 [Q9JHI2-1] |
Genome annotation databases
Ensembli | ENSMUST00000034427; ENSMUSP00000034427; ENSMUSG00000031949 [Q9JHI2-1] ENSMUST00000139820; ENSMUSP00000117279; ENSMUSG00000031949 [Q9JHI2-2] |
GeneIDi | 30947 |
KEGGi | mmu:30947 |
UCSCi | uc009nnc.1, mouse [Q9JHI2-1] uc012gkz.1, mouse [Q9JHI2-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF192375 mRNA Translation: AAF36820.1 AF192374 , AF192367, AF192368, AF192369, AF192370, AF192371, AF192372, AF192373 Genomic DNA Translation: AAF36821.1 AK035614 mRNA Translation: BAC29125.1 AK039699 mRNA Translation: BAC30422.1 AK082399 mRNA Translation: BAC38487.1 AK161044 mRNA Translation: BAE36167.1 BC019976 mRNA Translation: AAH19976.1 |
CCDSi | CCDS22684.1 [Q9JHI2-1] CCDS90464.1 [Q9JHI2-2] |
RefSeqi | NP_038953.1, NM_013925.4 [Q9JHI2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034427 |
PTM databases
iPTMneti | Q9JHI2 |
PhosphoSitePlusi | Q9JHI2 |
Proteomic databases
EPDi | Q9JHI2 |
PaxDbi | Q9JHI2 |
PeptideAtlasi | Q9JHI2 |
PRIDEi | Q9JHI2 |
Protocols and materials databases
Antibodypediai | 16832, 158 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034427; ENSMUSP00000034427; ENSMUSG00000031949 [Q9JHI2-1] ENSMUST00000139820; ENSMUSP00000117279; ENSMUSG00000031949 [Q9JHI2-2] |
GeneIDi | 30947 |
KEGGi | mmu:30947 |
UCSCi | uc009nnc.1, mouse [Q9JHI2-1] uc012gkz.1, mouse [Q9JHI2-3] |
Organism-specific databases
CTDi | 23536 |
MGIi | MGI:1353631, Adat1 |
Phylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000157942 |
HOGENOMi | CLU_005382_5_2_1 |
InParanoidi | Q9JHI2 |
OMAi | ASWIRNP |
OrthoDBi | 947117at2759 |
PhylomeDBi | Q9JHI2 |
TreeFami | TF315806 |
Miscellaneous databases
BioGRID-ORCSi | 30947, 0 hits in 17 CRISPR screens |
ChiTaRSi | Adat1, mouse |
PROi | PR:Q9JHI2 |
RNActi | Q9JHI2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031949, Expressed in retina and 187 other tissues |
ExpressionAtlasi | Q9JHI2, baseline and differential |
Genevisiblei | Q9JHI2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002466, A_deamin |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAT1_MOUSE | |
Accessioni | Q9JHI2Primary (citable) accession number: Q9JHI2 Secondary accession number(s): Q3TU04, Q8CBP0, Q8VE23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families