UniProtKB - Q9JHH5 (CXL11_MOUSE)
Protein
C-X-C motif chemokine 11
Gene
Cxcl11
Organism
Mus musculus (Mouse)
Status
Functioni
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).By similarity
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR3 chemokine receptor binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: UniProtKB
- immune response Source: GO_Central
- inflammatory response Source: GO_Central
- leukocyte chemotaxis Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 11Alternative name(s): Interferon-inducible T-cell alpha chemoattractant Short name: I-TAC Small-inducible cytokine B11 |
Gene namesi | Name:Cxcl11 Synonyms:Scyb11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1860203 Cxcl11 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cell Source: GOC
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000005107 | 22 – 100 | C-X-C motif chemokine 11Add BLAST | 79 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 57 | By similarity | ||
Disulfide bondi | 32 ↔ 74 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | Q9JHH5 |
PTM databases
PhosphoSitePlusi | Q9JHH5 |
Interactioni
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR3 chemokine receptor binding Source: UniProtKB
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | Q9JHH5 |
KOi | K12672 |
PhylomeDBi | Q9JHH5 |
Family and domain databases
CDDi | cd00273 Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR027221 CXCL11 IPR036048 Interleukin_8-like_sf |
PANTHERi | PTHR10179 PTHR10179, 1 hit PTHR10179:SF28 PTHR10179:SF28, 1 hit |
Pfami | View protein in Pfam PF00048 IL8, 1 hit |
PRINTSi | PR00437 SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199 SCY, 1 hit |
SUPFAMi | SSF54117 SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9JHH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRKVTAIAL AAIIWATAAQ GFLMFKQGRC LCIGPGMKAV KMAEIEKASV
60 70 80 90 100
IYPSNGCDKV EVIVTMKAHK RQRCLDPRSK QARLIMQAIE KKNFLRRQNM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QWR7 | M0QWR7_MOUSE | C-X-C motif chemokine | Cxcl11 | 99 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF178672 mRNA Translation: AAF79048.1 AF167354 Genomic DNA Translation: AAF71824.1 AF179872 mRNA Translation: AAF77095.1 AF136449 mRNA Translation: AAF79022.1 |
RefSeqi | NP_062367.1, NM_019494.1 |
Genome annotation databases
GeneIDi | 56066 |
KEGGi | mmu:56066 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF178672 mRNA Translation: AAF79048.1 AF167354 Genomic DNA Translation: AAF71824.1 AF179872 mRNA Translation: AAF77095.1 AF136449 mRNA Translation: AAF79022.1 |
RefSeqi | NP_062367.1, NM_019494.1 |
3D structure databases
SMRi | Q9JHH5 |
ModBasei | Search... |
PTM databases
PhosphoSitePlusi | Q9JHH5 |
Proteomic databases
PRIDEi | Q9JHH5 |
Genome annotation databases
GeneIDi | 56066 |
KEGGi | mmu:56066 |
Organism-specific databases
CTDi | 6373 |
MGIi | MGI:1860203 Cxcl11 |
Phylogenomic databases
InParanoidi | Q9JHH5 |
KOi | K12672 |
PhylomeDBi | Q9JHH5 |
Enzyme and pathway databases
Reactomei | R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:Q9JHH5 |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00273 Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR027221 CXCL11 IPR036048 Interleukin_8-like_sf |
PANTHERi | PTHR10179 PTHR10179, 1 hit PTHR10179:SF28 PTHR10179:SF28, 1 hit |
Pfami | View protein in Pfam PF00048 IL8, 1 hit |
PRINTSi | PR00437 SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199 SCY, 1 hit |
SUPFAMi | SSF54117 SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL11_MOUSE | |
Accessioni | Q9JHH5Primary (citable) accession number: Q9JHH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | September 18, 2019 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot