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Protein

Tetraspanin-32

Gene

Tspan32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • blood coagulation Source: MGI
  • cell surface receptor signaling pathway Source: GO_Central
  • cytoskeleton organization Source: MGI
  • defense response to protozoan Source: MGI
  • hemostasis Source: MGI
  • integrin-mediated signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of myeloid dendritic cell activation Source: MGI
  • platelet aggregation Source: MGI
  • regulation of defense response to virus Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-32
Short name:
Tspan-32
Alternative name(s):
AML1-regulated transmembrane protein 1
Protein Phemx
Gene namesi
Name:Tspan32
Synonyms:Art1, Phemx, Tssc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1350360 Tspan32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192791 – 256Tetraspanin-32Add BLAST256

Proteomic databases

PaxDbiQ9JHH2
PRIDEiQ9JHH2

PTM databases

PhosphoSitePlusiQ9JHH2

Expressioni

Tissue specificityi

Expressed exclusively in hematopoietic tissues. Expression detected in spleen, thymus, bone marrow and peripheral blood leukocytes but not in heart, brain, lung, liver, kidney or testis.1 Publication

Developmental stagei

Expressed from early embryogenesis through to adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000000244 Expressed in 132 organ(s), highest expression level in spleen
CleanExiMM_ART1
MM_TSPAN32
ExpressionAtlasiQ9JHH2 baseline and differential
GenevisibleiQ9JHH2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009396

Structurei

3D structure databases

ProteinModelPortaliQ9JHH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY3A Eukaryota
ENOG410YXBH LUCA
GeneTreeiENSGT00390000003287
HOVERGENiHBG053580
InParanoidiQ9JHH2
KOiK17359
OMAiCQMLVTS
OrthoDBiEOG091G0JTB
PhylomeDBiQ9JHH2
TreeFamiTF336277

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR008952 Tetraspanin_EC2_sf
PIRSFiPIRSF002419 Tetraspanin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 6 (identifier: Q9JHH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHWNRIKIA KCQILITNFL VLLLGLSMAT MVVVIHFGDH FTVIGHASLE
60 70 80 90 100
RNPYETLRYW AFYVGISLAG LLSLGAALST IATVREAHGL MAAGFLCFAL
110 120 130 140 150
SFCILVQVAF WRFYNPTQVE DAVLDTYDFV YDQAMKSPSS NWWQELAVIQ
160 170 180 190 200
DTFLCCGKKS PFGLLVSTGA IMCQGREAMR EDCLQSIRNV LWTHYSIASI
210 220 230 240 250
LTCTSLALTV YAMMLCAFLW FAIHSYHGLD RKGRYSLTPP RSHGFQTQEP

SLFRWT
Length:256
Mass (Da):28,906
Last modified:March 27, 2002 - v2
Checksum:iA20EF0F6248FF67A
GO
Isoform 1 (identifier: Q9JHH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:226
Mass (Da):25,525
Checksum:iAD5AE6916BD14BD2
GO
Isoform 2 (identifier: Q9JHH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     182-209: Missing.

Show »
Length:198
Mass (Da):22,419
Checksum:i3399ADE104D69B49
GO
Isoform 3 (identifier: Q9JHH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     182-206: DCLQSIRNVLWTHYSIASILTCTSL → IPWFPDPGTQPLQMDLGWAGASMPC
     207-236: Missing.

Show »
Length:196
Mass (Da):21,898
Checksum:iD7CFC3B0510C7157
GO
Isoform 4 (identifier: Q9JHH2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     119-152: Missing.
     182-209: Missing.

Show »
Length:164
Mass (Da):18,472
Checksum:i23E2CAF9AC04D11F
GO
Isoform 5 (identifier: Q9JHH2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     119-152: Missing.
     182-206: DCLQSIRNVLWTHYSIASILTCTSL → IPWFPDPGTQPLQMDLGWAGASMPC

Show »
Length:192
Mass (Da):21,455
Checksum:i93092F6EF11DF439
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TNQ7Q7TNQ7_MOUSE
Tetraspanin 32, isoform CRA_e
Tspan32 Phemx, mCG_11073
201Annotation score:
D3Z5A0D3Z5A0_MOUSE
Tetraspanin-32
Tspan32
179Annotation score:
Q3U3L6Q3U3L6_MOUSE
Tetraspanin 32, isoform CRA_b
Tspan32 mCG_11073
229Annotation score:
D3Z0S2D3Z0S2_MOUSE
Tetraspanin-32
Tspan32
185Annotation score:
G3X9S3G3X9S3_MOUSE
Tetraspanin 32, isoform CRA_c
Tspan32 mCG_11073
167Annotation score:
D3Z599D3Z599_MOUSE
Tetraspanin 32, isoform CRA_g
Tspan32 mCG_11073
145Annotation score:
D6RHS4D6RHS4_MOUSE
Tetraspanin-32
Tspan32
105Annotation score:
A0A140LIL2A0A140LIL2_MOUSE
Tetraspanin-32
Tspan32
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174Q → L in AAG27268 (PubMed:10950922).Curated1
Sequence conflicti235Y → F in AAG27268 (PubMed:10950922).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039391 – 30Missing in isoform 1, isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST30
Alternative sequenceiVSP_003940119 – 152Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_003941182 – 209Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_003942182 – 206DCLQS…TCTSL → IPWFPDPGTQPLQMDLGWAG ASMPC in isoform 3 and isoform 5. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_003943207 – 236Missing in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175771 mRNA Translation: AAG27268.1
AJ251788 Genomic DNA Translation: CAB94716.1
AJ251835 Genomic DNA Translation: CAB94777.1
AJ279791 mRNA Translation: CAB94719.1
AJ279792 mRNA Translation: CAB94720.1
AJ279793 mRNA Translation: CAB94721.1
AJ279794 mRNA Translation: CAB94722.1
AJ279795 mRNA Translation: CAB94723.1
AY039000 mRNA Translation: AAK84430.1
AF291425 mRNA Translation: AAK83110.1
CCDSiCCDS52459.1 [Q9JHH2-1]
RefSeqiNP_001121552.1, NM_001128080.2 [Q9JHH2-1]
NP_001121553.1, NM_001128081.1
NP_001121554.1, NM_001128082.1
NP_064682.1, NM_020286.3
UniGeneiMm.28172

Genome annotation databases

EnsembliENSMUST00000009396; ENSMUSP00000009396; ENSMUSG00000000244 [Q9JHH2-1]
GeneIDi27027
KEGGimmu:27027
UCSCiuc009kom.2 mouse [Q9JHH2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175771 mRNA Translation: AAG27268.1
AJ251788 Genomic DNA Translation: CAB94716.1
AJ251835 Genomic DNA Translation: CAB94777.1
AJ279791 mRNA Translation: CAB94719.1
AJ279792 mRNA Translation: CAB94720.1
AJ279793 mRNA Translation: CAB94721.1
AJ279794 mRNA Translation: CAB94722.1
AJ279795 mRNA Translation: CAB94723.1
AY039000 mRNA Translation: AAK84430.1
AF291425 mRNA Translation: AAK83110.1
CCDSiCCDS52459.1 [Q9JHH2-1]
RefSeqiNP_001121552.1, NM_001128080.2 [Q9JHH2-1]
NP_001121553.1, NM_001128081.1
NP_001121554.1, NM_001128082.1
NP_064682.1, NM_020286.3
UniGeneiMm.28172

3D structure databases

ProteinModelPortaliQ9JHH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009396

PTM databases

PhosphoSitePlusiQ9JHH2

Proteomic databases

PaxDbiQ9JHH2
PRIDEiQ9JHH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009396; ENSMUSP00000009396; ENSMUSG00000000244 [Q9JHH2-1]
GeneIDi27027
KEGGimmu:27027
UCSCiuc009kom.2 mouse [Q9JHH2-1]

Organism-specific databases

CTDi10077
MGIiMGI:1350360 Tspan32

Phylogenomic databases

eggNOGiENOG410IY3A Eukaryota
ENOG410YXBH LUCA
GeneTreeiENSGT00390000003287
HOVERGENiHBG053580
InParanoidiQ9JHH2
KOiK17359
OMAiCQMLVTS
OrthoDBiEOG091G0JTB
PhylomeDBiQ9JHH2
TreeFamiTF336277

Miscellaneous databases

PROiPR:Q9JHH2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000244 Expressed in 132 organ(s), highest expression level in spleen
CleanExiMM_ART1
MM_TSPAN32
ExpressionAtlasiQ9JHH2 baseline and differential
GenevisibleiQ9JHH2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR008952 Tetraspanin_EC2_sf
PIRSFiPIRSF002419 Tetraspanin, 1 hit
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN32_MOUSE
AccessioniPrimary (citable) accession number: Q9JHH2
Secondary accession number(s): Q923G9
, Q9ESH0, Q9JHQ9, Q9JHR0, Q9JHR1, Q9JHR2, Q9JHS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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