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Protein

Calcipressin-1

Gene

Rcan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093).1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Down syndrome critical region protein 1 homolog
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:Rcan1
Synonyms:Dscr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1890564 Rcan1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114151 – 251Calcipressin-1Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei216PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JHG6
PRIDEiQ9JHG6

PTM databases

iPTMnetiQ9JHG6
PhosphoSitePlusiQ9JHG6

Expressioni

Tissue specificityi

Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.2 Publications

Gene expression databases

BgeeiENSMUSG00000022951 Expressed in 341 organ(s), highest expression level in soleus muscle
CleanExiMM_RCAN1
ExpressionAtlasiQ9JHG6 baseline and differential
GenevisibleiQ9JHG6 MM

Interactioni

Subunit structurei

Interacts with RAF1 and PPP3R1 (By similarity). Interacts with PPP3CA (PubMed:12809556).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JHG6, 4 interactors
MINTiQ9JHG6
STRINGi10090.ENSMUSP00000060394

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JHG6
SMRiQ9JHG6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JHG6

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 228Poly-GluSequence analysis10

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JHG6
KOiK17901
OMAiPNALIAC
OrthoDBiEOG091G0OZ7
PhylomeDBiQ9JHG6
TreeFamiTF313579

Family and domain databases

CDDicd12708 RRM_RCAN1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q9JHG6-1) [UniParc]FASTAAdd to basket
Also known as: 1, CALP1-L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDGVAGPRL GEVAEAVEAR APRRVTLRPF APFSAAAEGD GGGGGDWSFI
60 70 80 90 100
DCEMEEVDLQ DLPSATIACH LDPRVFVDGL CRAKFESLFR TYDKDTTFQY
110 120 130 140 150
FKSFKRVRIN FSNPLSAADA RLRLHKTEFL GKEMKLYFAQ TLHIGSSHLA
160 170 180 190 200
PPNPDKQFLI SPPASPPVGW KQVEDATPVI NYDLLYAISK LGPGEKYELH
210 220 230 240 250
AATDTTPSVV VHVCESDQEN EEEEEEMERM KRPKPKIIQT RRPEYTPIHL

S
Length:251
Mass (Da):28,137
Last modified:May 23, 2018 - v2
Checksum:i09F47C73D847FB2B
GO
Isoform B (identifier: Q9JHG6-2) [UniParc]FASTAAdd to basket
Also known as: 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MEDGVAGPRL...DPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET

Show »
Length:198
Mass (Da):22,851
Checksum:iF017C68F18ACC187
GO
Isoform C (identifier: Q9JHG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:118
Mass (Da):13,378
Checksum:iDC4A1EE03245E50B
GO
Isoform E (identifier: Q9JHG6-4) [UniParc]FASTAAdd to basket
Also known as: CALP1-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:198
Mass (Da):22,706
Checksum:iBA35340AFD6F0582
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7E2A0A338P7E2_MOUSE
Calcipressin-1
Rcan1
59Annotation score:

Sequence cautioni

The sequence AAF91461 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205T → P in AAF63485 (PubMed:10722714).Curated1
Sequence conflicti205T → P in AAF63486 (PubMed:10722714).Curated1
Isoform B (identifier: Q9JHG6-2)
Sequence conflicti2H → D in AAF63486 (PubMed:10722714).Curated1
Sequence conflicti6F → Y in AAF72701 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0013181 – 133Missing in isoform C. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_0013171 – 81MEDGV…VDGLC → MHFRDFSYNFSSLIACVAND DVFSESET in isoform B. 3 PublicationsAdd BLAST81
Alternative sequenceiVSP_0595681 – 53Missing in isoform E. 2 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237789 mRNA Translation: AAF63485.1
AF237790 mRNA Translation: AAF63486.1
AF260717 mRNA Translation: AAF70343.1
AY325904 mRNA Translation: AAP96744.1
AF263239 mRNA Translation: AAF72701.1
AF263240 mRNA Translation: AAF72702.1
AK010696 mRNA Translation: BAB27128.1
AK146764 mRNA Translation: BAE27416.1
AC162305 Genomic DNA No translation available.
AC174448 Genomic DNA No translation available.
BC013551 mRNA Translation: AAH13551.1
AF282255 mRNA Translation: AAF91461.1 Different initiation.
CCDSiCCDS28337.1 [Q9JHG6-2]
CCDS37405.1 [Q9JHG6-1]
RefSeqiNP_001075018.1, NM_001081549.2 [Q9JHG6-1]
NP_062339.2, NM_019466.4 [Q9JHG6-2]
UniGeneiMm.265744

Genome annotation databases

EnsembliENSMUST00000023672; ENSMUSP00000023672; ENSMUSG00000022951 [Q9JHG6-2]
ENSMUST00000060005; ENSMUSP00000060394; ENSMUSG00000022951 [Q9JHG6-1]
ENSMUST00000231410; ENSMUSP00000156110; ENSMUSG00000022951 [Q9JHG6-3]
ENSMUST00000232197; ENSMUSP00000155863; ENSMUSG00000022951 [Q9JHG6-3]
ENSMUST00000232239; ENSMUSP00000156053; ENSMUSG00000022951 [Q9JHG6-4]
GeneIDi54720
KEGGimmu:54720
UCSCiuc007zze.2 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237789 mRNA Translation: AAF63485.1
AF237790 mRNA Translation: AAF63486.1
AF260717 mRNA Translation: AAF70343.1
AY325904 mRNA Translation: AAP96744.1
AF263239 mRNA Translation: AAF72701.1
AF263240 mRNA Translation: AAF72702.1
AK010696 mRNA Translation: BAB27128.1
AK146764 mRNA Translation: BAE27416.1
AC162305 Genomic DNA No translation available.
AC174448 Genomic DNA No translation available.
BC013551 mRNA Translation: AAH13551.1
AF282255 mRNA Translation: AAF91461.1 Different initiation.
CCDSiCCDS28337.1 [Q9JHG6-2]
CCDS37405.1 [Q9JHG6-1]
RefSeqiNP_001075018.1, NM_001081549.2 [Q9JHG6-1]
NP_062339.2, NM_019466.4 [Q9JHG6-2]
UniGeneiMm.265744

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEYNMR-A67-156[»]
ProteinModelPortaliQ9JHG6
SMRiQ9JHG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JHG6, 4 interactors
MINTiQ9JHG6
STRINGi10090.ENSMUSP00000060394

PTM databases

iPTMnetiQ9JHG6
PhosphoSitePlusiQ9JHG6

Proteomic databases

PaxDbiQ9JHG6
PRIDEiQ9JHG6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023672; ENSMUSP00000023672; ENSMUSG00000022951 [Q9JHG6-2]
ENSMUST00000060005; ENSMUSP00000060394; ENSMUSG00000022951 [Q9JHG6-1]
ENSMUST00000231410; ENSMUSP00000156110; ENSMUSG00000022951 [Q9JHG6-3]
ENSMUST00000232197; ENSMUSP00000155863; ENSMUSG00000022951 [Q9JHG6-3]
ENSMUST00000232239; ENSMUSP00000156053; ENSMUSG00000022951 [Q9JHG6-4]
GeneIDi54720
KEGGimmu:54720
UCSCiuc007zze.2 mouse

Organism-specific databases

CTDi1827
MGIiMGI:1890564 Rcan1

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JHG6
KOiK17901
OMAiPNALIAC
OrthoDBiEOG091G0OZ7
PhylomeDBiQ9JHG6
TreeFamiTF313579

Miscellaneous databases

ChiTaRSiRcan1 mouse
EvolutionaryTraceiQ9JHG6
PROiPR:Q9JHG6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022951 Expressed in 341 organ(s), highest expression level in soleus muscle
CleanExiMM_RCAN1
ExpressionAtlasiQ9JHG6 baseline and differential
GenevisibleiQ9JHG6 MM

Family and domain databases

CDDicd12708 RRM_RCAN1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG6
Secondary accession number(s): Q7TNY3
, Q91WQ4, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 23, 2018
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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