Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcipressin-2

Gene

Rcan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase regulator activity Source: GO_Central
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: MGI
  • locomotion involved in locomotory behavior Source: MGI
  • Notch signaling pathway Source: MGI
  • regulation of calcineurin-NFAT signaling cascade Source: GO_Central
  • response to oxidative stress Source: MGI
  • short-term memory Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Calcineurin inhibitory protein ZAKI-4
Down syndrome candidate region 1-like protein 1
Myocyte-enriched calcineurin-interacting protein 2
Short name:
MCIP2
Regulator of calcineurin 2
Gene namesi
Name:Rcan2
Synonyms:Dscr1l1, Zaki4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1858219 Rcan2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114181 – 197Calcipressin-2Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JHG2
PRIDEiQ9JHG2

PTM databases

iPTMnetiQ9JHG2
PhosphoSitePlusiQ9JHG2

Expressioni

Tissue specificityi

Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues.

Gene expression databases

BgeeiENSMUSG00000039601 Expressed in 236 organ(s), highest expression level in interventricular septum
CleanExiMM_RCAN2
ExpressionAtlasiQ9JHG2 baseline and differential
GenevisibleiQ9JHG2 MM

Structurei

3D structure databases

ProteinModelPortaliQ9JHG2
SMRiQ9JHG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JHG2
KOiK17903
PhylomeDBiQ9JHG2

Family and domain databases

CDDicd12709 RRM_RCAN2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034921 RCAN2
IPR034919 RCAN2_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF5 PTHR10300:SF5, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9JHG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS
60 70 80 90 100
FRRVRINFSH PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WKPISDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDME EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):22,025
Last modified:October 1, 2000 - v1
Checksum:iCE1306B7B03E70F1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8VIP4Q8VIP4_MOUSE
Calcineurin inhibitory protein ZAKI...
Rcan2 Dscr1l1, ZAKI-4 beta, mCG_51170
243Annotation score:
A0A2R8VKI0A0A2R8VKI0_MOUSE
Calcipressin-2
Rcan2
128Annotation score:
A0A2R8W6E8A0A2R8W6E8_MOUSE
Calcipressin-2
Rcan2
228Annotation score:
A0A2R8W6X3A0A2R8W6X3_MOUSE
Calcipressin-2
Rcan2
29Annotation score:

Sequence cautioni

The sequence BAB71955 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77R → K in BAB71955 (Ref. 3) Curated1
Sequence conflicti132N → K in BAB71955 (Ref. 3) Curated1
Sequence conflicti177T → N in BAB71955 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237791 mRNA Translation: AAF63487.1
AF237887 mRNA Translation: AAF62538.1
AB061524 mRNA Translation: BAB71955.1 Different initiation.
BC047153 mRNA Translation: AAH47153.1
BC049096 mRNA Translation: AAH49096.1
BC062141 mRNA Translation: AAH62141.1
CCDSiCCDS28801.1
RefSeqiNP_001273583.1, NM_001286654.1
NP_085101.1, NM_030598.2
NP_997532.1, NM_207649.1
UniGeneiMm.251242

Genome annotation databases

EnsembliENSMUST00000044792; ENSMUSP00000048013; ENSMUSG00000039601
ENSMUST00000177857; ENSMUSP00000137211; ENSMUSG00000039601
GeneIDi53901
KEGGimmu:53901
UCSCiuc008cpp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237791 mRNA Translation: AAF63487.1
AF237887 mRNA Translation: AAF62538.1
AB061524 mRNA Translation: BAB71955.1 Different initiation.
BC047153 mRNA Translation: AAH47153.1
BC049096 mRNA Translation: AAH49096.1
BC062141 mRNA Translation: AAH62141.1
CCDSiCCDS28801.1
RefSeqiNP_001273583.1, NM_001286654.1
NP_085101.1, NM_030598.2
NP_997532.1, NM_207649.1
UniGeneiMm.251242

3D structure databases

ProteinModelPortaliQ9JHG2
SMRiQ9JHG2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9JHG2
PhosphoSitePlusiQ9JHG2

Proteomic databases

MaxQBiQ9JHG2
PRIDEiQ9JHG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044792; ENSMUSP00000048013; ENSMUSG00000039601
ENSMUST00000177857; ENSMUSP00000137211; ENSMUSG00000039601
GeneIDi53901
KEGGimmu:53901
UCSCiuc008cpp.1 mouse

Organism-specific databases

CTDi10231
MGIiMGI:1858219 Rcan2

Phylogenomic databases

GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JHG2
KOiK17903
PhylomeDBiQ9JHG2

Miscellaneous databases

ChiTaRSiRcan2 mouse
PROiPR:Q9JHG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039601 Expressed in 236 organ(s), highest expression level in interventricular septum
CleanExiMM_RCAN2
ExpressionAtlasiQ9JHG2 baseline and differential
GenevisibleiQ9JHG2 MM

Family and domain databases

CDDicd12709 RRM_RCAN2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034921 RCAN2
IPR034919 RCAN2_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF5 PTHR10300:SF5, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG2
Secondary accession number(s): Q8VIP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again