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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Gene

Pigp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: MGI

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi2.4.1.198 3474
ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayi
UPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC:2.4.1.198)
Alternative name(s):
Down syndrome critical region protein 5 homolog
Phosphatidylinositol-glycan biosynthesis class P protein
Short name:
PIG-P
Gene namesi
Name:Pigp
Synonyms:Dcrc, Dscr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1860433 Pigp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917841 – 132Phosphatidylinositol N-acetylglucosaminyltransferase subunit PAdd BLAST132

Proteomic databases

PaxDbiQ9JHG1
PRIDEiQ9JHG1

PTM databases

iPTMnetiQ9JHG1
PhosphoSitePlusiQ9JHG1

Expressioni

Tissue specificityi

Expressed in tongue.1 Publication

Gene expression databases

BgeeiENSMUSG00000022940 Expressed in 39 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9JHG1 baseline and differential
GenevisibleiQ9JHG1 MM

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109547

Structurei

3D structure databases

SMRiQ9JHG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2257 Eukaryota
ENOG41121KH LUCA
GeneTreeiENSGT00390000013771
HOGENOMiHOG000007030
HOVERGENiHBG000430
InParanoidiQ9JHG1
KOiK03861
PhylomeDBiQ9JHG1

Family and domain databases

InterProiView protein in InterPro
IPR013717 PIG-P
IPR016542 PIG-P_GPI19
PfamiView protein in Pfam
PF08510 PIG-P, 1 hit
PIRSFiPIRSF008765 PIG-P_GPI19, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9JHG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVENSPSPLP ERAIYGFVLF LSSQFGFILY LVWAFVPESW LNSLGLTYWP
60 70 80 90 100
QKYWAVALPV YLLITVVIGY VLLFGINMMS TSPLDSIHTI TDNYAKNQQR
110 120 130
KNYQEDAIPA LRDVPISEVN KMFFLGAKEL NT
Length:132
Mass (Da):15,101
Last modified:October 1, 2000 - v1
Checksum:iD21472651F850F9D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JK67B8JK67_MOUSE
MCG19610, isoform CRA_d
Pigp mCG_19610
205Annotation score:
B8JK65B8JK65_MOUSE
Phosphatidylinositol N-acetylglucos...
Pigp
139Annotation score:
B8JK66B8JK66_MOUSE
MCG19610, isoform CRA_c
Pigp mCG_19610
161Annotation score:
B8JK63B8JK63_MOUSE
Phosphatidylinositol N-acetylglucos...
Pigp
151Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216306 mRNA Translation: AAF32294.1
AF216307 mRNA Translation: AAF32295.1
AF216308 mRNA Translation: AAF32296.1
AF216309 mRNA Translation: AAF32297.1
AK004169 mRNA Translation: BAB23204.1
BC038252 mRNA Translation: AAH38252.1
BC061116 mRNA Translation: AAH61116.1
BC096569 mRNA Translation: AAH96569.1
CCDSiCCDS28348.1
RefSeqiNP_001153088.1, NM_001159616.1
NP_001153089.1, NM_001159617.1
NP_001153090.1, NM_001159618.1
NP_001153091.1, NM_001159619.1
NP_062416.1, NM_019543.3
UniGeneiMm.474449

Genome annotation databases

EnsembliENSMUST00000113905; ENSMUSP00000109538; ENSMUSG00000022940
ENSMUST00000113906; ENSMUSP00000109539; ENSMUSG00000022940
ENSMUST00000232294; ENSMUSP00000155972; ENSMUSG00000022940
GeneIDi56176
KEGGimmu:56176
UCSCiuc008aan.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

PIG-P_DCRC-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216306 mRNA Translation: AAF32294.1
AF216307 mRNA Translation: AAF32295.1
AF216308 mRNA Translation: AAF32296.1
AF216309 mRNA Translation: AAF32297.1
AK004169 mRNA Translation: BAB23204.1
BC038252 mRNA Translation: AAH38252.1
BC061116 mRNA Translation: AAH61116.1
BC096569 mRNA Translation: AAH96569.1
CCDSiCCDS28348.1
RefSeqiNP_001153088.1, NM_001159616.1
NP_001153089.1, NM_001159617.1
NP_001153090.1, NM_001159618.1
NP_001153091.1, NM_001159619.1
NP_062416.1, NM_019543.3
UniGeneiMm.474449

3D structure databases

SMRiQ9JHG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109547

PTM databases

iPTMnetiQ9JHG1
PhosphoSitePlusiQ9JHG1

Proteomic databases

PaxDbiQ9JHG1
PRIDEiQ9JHG1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113905; ENSMUSP00000109538; ENSMUSG00000022940
ENSMUST00000113906; ENSMUSP00000109539; ENSMUSG00000022940
ENSMUST00000232294; ENSMUSP00000155972; ENSMUSG00000022940
GeneIDi56176
KEGGimmu:56176
UCSCiuc008aan.2 mouse

Organism-specific databases

CTDi51227
MGIiMGI:1860433 Pigp

Phylogenomic databases

eggNOGiKOG2257 Eukaryota
ENOG41121KH LUCA
GeneTreeiENSGT00390000013771
HOGENOMiHOG000007030
HOVERGENiHBG000430
InParanoidiQ9JHG1
KOiK03861
PhylomeDBiQ9JHG1

Enzyme and pathway databases

UniPathwayi
UPA00196

BRENDAi2.4.1.198 3474
ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)

Miscellaneous databases

PROiPR:Q9JHG1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022940 Expressed in 39 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9JHG1 baseline and differential
GenevisibleiQ9JHG1 MM

Family and domain databases

InterProiView protein in InterPro
IPR013717 PIG-P
IPR016542 PIG-P_GPI19
PfamiView protein in Pfam
PF08510 PIG-P, 1 hit
PIRSFiPIRSF008765 PIG-P_GPI19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIGP_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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