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Protein

Hematopoietic prostaglandin D synthase

Gene

Hpgds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity.2 Publications

Catalytic activityi

(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.1 Publication
RX + glutathione = HX + R-S-glutathione.1 Publication

Cofactori

glutathione1 PublicationNote: Glutathione is required for the prostaglandin D synthase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei14GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of male germ cell proliferation Source: MGI
  • prostaglandin biosynthetic process Source: UniProtKB-KW
  • prostaglandin metabolic process Source: MGI

Keywordsi

Molecular functionIsomerase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiQ9JHF7

Chemistry databases

SwissLipidsiSLP:000000829

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietic prostaglandin D synthase (EC:5.3.99.21 Publication)
Short name:
H-PGDS
Alternative name(s):
GST class-sigma
Glutathione S-transferase (EC:2.5.1.181 Publication)
Glutathione-dependent PGD synthase
Glutathione-requiring prostaglandin D synthase
Prostaglandin-H2 D-isomerase
Gene namesi
Name:Hpgds
Synonyms:Gsts, Pgds, Ptgds2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1859384 Hpgds

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859351 – 199Hematopoietic prostaglandin D synthaseAdd BLAST199

Proteomic databases

MaxQBiQ9JHF7
PaxDbiQ9JHF7
PeptideAtlasiQ9JHF7
PRIDEiQ9JHF7

PTM databases

iPTMnetiQ9JHF7
PhosphoSitePlusiQ9JHF7

Expressioni

Tissue specificityi

Expressed in skin and oviduct.1 Publication

Gene expression databases

BgeeiENSMUSG00000029919 Expressed in 115 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_PTGDS2
GenevisibleiQ9JHF7 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031982

Chemistry databases

BindingDBiQ9JHF7

Structurei

3D structure databases

ProteinModelPortaliQ9JHF7
SMRiQ9JHF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 199GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
HOVERGENiHBG105321
InParanoidiQ9JHF7
KOiK04097
OMAiAIKTWVA
OrthoDBiEOG091G0MBB
PhylomeDBiQ9JHF7
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNYKLLYFN MRGRAEIIRY IFAYLDIKYE DHRIEQADWP KIKPTLPFGK
60 70 80 90 100
IPVLEVEGLT IHQSLAIARY LTKNTDLAGK TALEQCQADA VVDTLDDFMS
110 120 130 140 150
LFPWAEKDQD LKERMFNELL THQAPRLLKD LDTYLGDKEW FIGNYVTWAD
160 170 180 190
FYWDICSTTL LVLKPGLLDI YPKLVSLRNK VQAIPAISAW ILKRPQTKL
Length:199
Mass (Da):23,227
Last modified:January 23, 2007 - v3
Checksum:iE5E7E4B56493F720
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108D → G in BAC30336 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008824 Genomic DNA Translation: BAA97557.1
D82072 mRNA Translation: BAA96845.1
AK020246 mRNA Translation: BAB32037.1
AK039392 mRNA Translation: BAC30336.1
CH466523 Genomic DNA Translation: EDK98774.1
BC116735 mRNA Translation: AAI16736.1
BC116737 mRNA Translation: AAI16738.1
CCDSiCCDS20205.1
RefSeqiNP_062328.3, NM_019455.4
UniGeneiMm.410688

Genome annotation databases

EnsembliENSMUST00000031982; ENSMUSP00000031982; ENSMUSG00000029919
GeneIDi54486
KEGGimmu:54486
UCSCiuc009cee.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008824 Genomic DNA Translation: BAA97557.1
D82072 mRNA Translation: BAA96845.1
AK020246 mRNA Translation: BAB32037.1
AK039392 mRNA Translation: BAC30336.1
CH466523 Genomic DNA Translation: EDK98774.1
BC116735 mRNA Translation: AAI16736.1
BC116737 mRNA Translation: AAI16738.1
CCDSiCCDS20205.1
RefSeqiNP_062328.3, NM_019455.4
UniGeneiMm.410688

3D structure databases

ProteinModelPortaliQ9JHF7
SMRiQ9JHF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031982

Chemistry databases

BindingDBiQ9JHF7
ChEMBLiCHEMBL3309049
SwissLipidsiSLP:000000829

PTM databases

iPTMnetiQ9JHF7
PhosphoSitePlusiQ9JHF7

Proteomic databases

MaxQBiQ9JHF7
PaxDbiQ9JHF7
PeptideAtlasiQ9JHF7
PRIDEiQ9JHF7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031982; ENSMUSP00000031982; ENSMUSG00000029919
GeneIDi54486
KEGGimmu:54486
UCSCiuc009cee.2 mouse

Organism-specific databases

CTDi27306
MGIiMGI:1859384 Hpgds

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
HOVERGENiHBG105321
InParanoidiQ9JHF7
KOiK04097
OMAiAIKTWVA
OrthoDBiEOG091G0MBB
PhylomeDBiQ9JHF7
TreeFamiTF105321

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiQ9JHF7

Miscellaneous databases

PROiPR:Q9JHF7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029919 Expressed in 115 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_PTGDS2
GenevisibleiQ9JHF7 MM

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHPGDS_MOUSE
AccessioniPrimary (citable) accession number: Q9JHF7
Secondary accession number(s): Q14AR4, Q8CA80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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