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Protein

Ninjurin-2

Gene

Ninj2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-2
Alternative name(s):
Nerve injury-induced protein 2
Gene namesi
Name:Ninj2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620552 Ninj2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67ExtracellularSequence analysisAdd BLAST67
Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Topological domaini91 – 108CytoplasmicSequence analysisAdd BLAST18
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 144ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596481 – 144Ninjurin-2Add BLAST144

Proteomic databases

PaxDbiQ9JHE8
PRIDEiQ9JHE8

Expressioni

Inductioni

By nerve injury; in Schwann cells.

Gene expression databases

BgeeiENSRNOG00000010282 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ9JHE8 RN

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0D7 Eukaryota
ENOG4111YA5 LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiQ9JHE8
OMAiRSPPINL
OrthoDBiEOG091G0TAH
PhylomeDBiQ9JHE8
TreeFamiTF323538

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
PANTHERiPTHR12316 PTHR12316, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESDREIIHL QHRHSTPGGN QRHINLNHYA TKKSVAESML DVALFMSNAM
60 70 80 90 100
RLKSVLEQGP FSQYYTTLLT LISASLLLQV VIGILLVVIA RLNLNEVENQ
110 120 130 140
WRLNQLNNAA TTLVFITVVI NIFITAFGAH KTGSVAARTS SNPI
Length:144
Mass (Da):15,996
Last modified:October 1, 2000 - v1
Checksum:iEED7A2ACA61A838D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040815 mRNA Translation: BAA94291.1
AF250322 mRNA Translation: AAF65567.1
RefSeqiNP_067606.1, NM_021595.2
UniGeneiRn.162768

Genome annotation databases

EnsembliENSRNOT00000013721; ENSRNOP00000013721; ENSRNOG00000010282
GeneIDi59115
KEGGirno:59115
UCSCiRGD:620552 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040815 mRNA Translation: BAA94291.1
AF250322 mRNA Translation: AAF65567.1
RefSeqiNP_067606.1, NM_021595.2
UniGeneiRn.162768

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9JHE8
PRIDEiQ9JHE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013721; ENSRNOP00000013721; ENSRNOG00000010282
GeneIDi59115
KEGGirno:59115
UCSCiRGD:620552 rat

Organism-specific databases

CTDi4815
RGDi620552 Ninj2

Phylogenomic databases

eggNOGiENOG410J0D7 Eukaryota
ENOG4111YA5 LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiQ9JHE8
OMAiRSPPINL
OrthoDBiEOG091G0TAH
PhylomeDBiQ9JHE8
TreeFamiTF323538

Miscellaneous databases

PROiPR:Q9JHE8

Gene expression databases

BgeeiENSRNOG00000010282 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ9JHE8 RN

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
PANTHERiPTHR12316 PTHR12316, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNINJ2_RAT
AccessioniPrimary (citable) accession number: Q9JHE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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