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Protein

Transcription cofactor HES-6

Gene

Hes6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor HES-6
Alternative name(s):
Hairy and enhancer of split 6
Gene namesi
Name:Hes6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1859852 Hes6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272151 – 224Transcription cofactor HES-6Add BLAST224

Proteomic databases

PaxDbiQ9JHE6
PRIDEiQ9JHE6

PTM databases

PhosphoSitePlusiQ9JHE6

Expressioni

Tissue specificityi

Expressed in both undifferentiated and differentiated cells. High levels of expression are observed in several embryonic tissues including the nervous system, muscle and thymus. In the nervous system, initially expressed in the closing neural tube, then in the spinal cord, cranial and dorsal root ganglia, and brain neuroepithelium. Also expressed in epithelial cells of the embryonic respiratory, urinary and digestive systems. In the limb buds, expressed in skeletal muscle and presumptive tendons.2 Publications

Developmental stagei

Expressed in both embryo and adult. Expression in the embryo is detected from E8.5. In the retina, expressed at high levels at postnatal E0. Expression in brain and retina decreases postnatally but still detectable in adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000067071 Expressed in 372 organ(s), highest expression level in retina
CleanExiMM_HES6
GenevisibleiQ9JHE6 MM

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity). Interacts with HES1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207731, 5 interactors
STRINGi10090.ENSMUSP00000084062

Structurei

3D structure databases

ProteinModelPortaliQ9JHE6
SMRiQ9JHE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 77bHLHPROSITE-ProRule annotationAdd BLAST53
Domaini96 – 129OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 224WRPW motif4

Domaini

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG107098
InParanoidiQ9JHE6
KOiK09087
OMAiQSVWRPW
OrthoDBiEOG091G0OZ5
PhylomeDBiQ9JHE6
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSQAPSRD RAGQEDEDRW EARGDRKARK PLVEKKRRAR INESLQELRL
60 70 80 90 100
LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA EASERFAAGY
110 120 130 140 150
IQCMHEVHTF VSTCQAIDAT VSAELLNHLL ESMPLREGSS FQDLLGDSLA
160 170 180 190 200
GLPGGSGRSS WPPGGSPESP LSSPPGPGDD LCSDLEEIPE AELNRVPAEG
210 220
PDLVSTSLGS LTAARRAQSV WRPW
Length:224
Mass (Da):24,454
Last modified:October 1, 2000 - v1
Checksum:iF5160A69D913DBE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035178 mRNA Translation: BAA96081.1
AF247040 mRNA Translation: AAF63757.1
AF260236 mRNA Translation: AAK51633.1
AK013443 mRNA Translation: BAB28856.1
AK076135 mRNA Translation: BAC36210.1
AK155340 mRNA Translation: BAE33204.1
BC012897 mRNA Translation: AAH12897.1
CCDSiCCDS15163.1
RefSeqiNP_062352.1, NM_019479.3
UniGeneiMm.280029

Genome annotation databases

EnsembliENSMUST00000086851; ENSMUSP00000084062; ENSMUSG00000067071
GeneIDi55927
KEGGimmu:55927
UCSCiuc007cau.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035178 mRNA Translation: BAA96081.1
AF247040 mRNA Translation: AAF63757.1
AF260236 mRNA Translation: AAK51633.1
AK013443 mRNA Translation: BAB28856.1
AK076135 mRNA Translation: BAC36210.1
AK155340 mRNA Translation: BAE33204.1
BC012897 mRNA Translation: AAH12897.1
CCDSiCCDS15163.1
RefSeqiNP_062352.1, NM_019479.3
UniGeneiMm.280029

3D structure databases

ProteinModelPortaliQ9JHE6
SMRiQ9JHE6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207731, 5 interactors
STRINGi10090.ENSMUSP00000084062

PTM databases

PhosphoSitePlusiQ9JHE6

Proteomic databases

PaxDbiQ9JHE6
PRIDEiQ9JHE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086851; ENSMUSP00000084062; ENSMUSG00000067071
GeneIDi55927
KEGGimmu:55927
UCSCiuc007cau.1 mouse

Organism-specific databases

CTDi55502
MGIiMGI:1859852 Hes6

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG107098
InParanoidiQ9JHE6
KOiK09087
OMAiQSVWRPW
OrthoDBiEOG091G0OZ5
PhylomeDBiQ9JHE6
TreeFamiTF351373

Miscellaneous databases

ChiTaRSiHes6 mouse
PROiPR:Q9JHE6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067071 Expressed in 372 organ(s), highest expression level in retina
CleanExiMM_HES6
GenevisibleiQ9JHE6 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES6_MOUSE
AccessioniPrimary (citable) accession number: Q9JHE6
Secondary accession number(s): Q3U2D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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