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Entry version 111 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

Slc38a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-methyl-D-glucamine and choline.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.53 mM for alanine (at pH 7.4)4 Publications
  2. KM=1.65 mM for glutamine (at pH 7.4)4 Publications
  3. KM=0.94 mM for serine (at pH 8.0)4 Publications
  4. KM=0.23 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0)1 Publication
  5. KM=0.14 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0)1 Publication
  6. KM=0.53 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 7.4)4 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-210500, Glutamate Neurotransmitter Release Cycle
    R-RNO-352230, Amino acid transport across the plasma membrane

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9JHE5

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.18.6.4, the amino acid/auxin permease (aaap) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Slc38a2
    Synonyms:Ata2, Sa1, Sat2, Snat2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    69420, Slc38a2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
    Topological domaini98 – 102ExtracellularSequence analysis5
    Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
    Topological domaini124 – 158CytoplasmicSequence analysisAdd BLAST35
    Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
    Topological domaini180 – 188ExtracellularSequence analysis9
    Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
    Topological domaini210 – 217CytoplasmicSequence analysis8
    Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
    Topological domaini239 – 290ExtracellularSequence analysisAdd BLAST52
    Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
    Topological domaini312 – 327CytoplasmicSequence analysisAdd BLAST16
    Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
    Topological domaini349 – 369ExtracellularSequence analysisAdd BLAST21
    Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
    Topological domaini391 – 411CytoplasmicSequence analysisAdd BLAST21
    Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
    Topological domaini433 – 434ExtracellularSequence analysis2
    Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
    Topological domaini456 – 472CytoplasmicSequence analysisAdd BLAST17
    Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
    Topological domaini494 – 504ExtracellularSequence analysisAdd BLAST11

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi504H → A: Modifies the transporter pH-sensitivity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003113721 – 504Sodium-coupled neutral amino acid transporter 2Add BLAST504

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineBy similarity1
    Modified residuei21PhosphoserineBy similarity1
    Modified residuei22PhosphoserineBy similarity1
    Modified residuei55PhosphoserineBy similarity1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi245 ↔ 2791 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9JHE5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9JHE5

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q9JHE5, 2 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9JHE5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9JHE5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed in skeletal muscle and adipose tissue (at protein level). Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).5 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulation upon amino acid deprivation results from both increased transcription and protein stabilization. Up-regulated by TGFB1.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000006305, Expressed in esophagus and 20 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9JHE5, RN

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000031532

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96Regulates protein turnover upon amino acid deprivationAdd BLAST96

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1305, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155486

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009020_0_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9JHE5

    KEGG Orthology (KO)

    More...
    KOi
    K14207

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IVFAYTC

    Database of Orthologous Groups

    More...
    OrthoDBi
    1109791at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9JHE5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF328787

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013057, AA_transpt_TM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01490, Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9JHE5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKKTEMGRFN ISPDEDSSSY SSNGDFNYSY PTKQAALKSH YVDVDPENQN
    60 70 80 90 100
    FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
    110 120 130 140 150
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AYGLAGKLAA
    160 170 180 190 200
    SGSITMQNIG AMSSYLFIVK YELPLVIKAL MNIEDTNGLW YLNGDYLVLL
    210 220 230 240 250
    VSFVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK FQIPCPVEVA
    260 270 280 290 300
    LMANETVNGT FTQVALAALA SNSTAADTCR PRYFIFNSQT VYAVPILTFS
    310 320 330 340 350
    FVCHPAVLPI YEELKSRSRR RMMNVSKISF FAMFLMYLLA ALFGYLTFYE
    360 370 380 390 400
    HVESELLHTY SAIVGTDILL LVVRLAVLVA VTLTVPVVIF PIRSSVTHLL
    410 420 430 440 450
    CPTKEFSWFR HSVITVTILA FTNLLVIFVP TIRDIFGFIG ASAAAMLIFI
    460 470 480 490 500
    LPSAFYIKLV KKEPMRSVQK IGALCFLLSG VVVMIGSMGL IVLDWVHDAS

    AGGH
    Length:504
    Mass (Da):55,554
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF53022C07152648C
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69G → S in AAF74195 (PubMed:10747860).Curated1
    Sequence conflicti81S → T in AAF74195 (PubMed:10747860).Curated1
    Sequence conflicti87S → N in AAF74195 (PubMed:10747860).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF249673 mRNA Translation: AAF74195.1
    AF173682 mRNA Translation: AAF75589.2
    AF273024 mRNA Translation: AAF81796.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_851604.1, NM_181090.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000039002; ENSRNOP00000031532; ENSRNOG00000006305

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    29642

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:29642

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF249673 mRNA Translation: AAF74195.1
    AF173682 mRNA Translation: AAF75589.2
    AF273024 mRNA Translation: AAF81796.1
    RefSeqiNP_851604.1, NM_181090.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031532

    Protein family/group databases

    TCDBi2.A.18.6.4, the amino acid/auxin permease (aaap) family

    PTM databases

    GlyGeniQ9JHE5, 2 sites
    iPTMnetiQ9JHE5
    PhosphoSitePlusiQ9JHE5

    Proteomic databases

    PaxDbiQ9JHE5
    PRIDEiQ9JHE5

    Genome annotation databases

    EnsembliENSRNOT00000039002; ENSRNOP00000031532; ENSRNOG00000006305
    GeneIDi29642
    KEGGirno:29642

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    54407
    RGDi69420, Slc38a2

    Phylogenomic databases

    eggNOGiKOG1305, Eukaryota
    GeneTreeiENSGT00940000155486
    HOGENOMiCLU_009020_0_1_1
    InParanoidiQ9JHE5
    KOiK14207
    OMAiIVFAYTC
    OrthoDBi1109791at2759
    PhylomeDBiQ9JHE5
    TreeFamiTF328787

    Enzyme and pathway databases

    ReactomeiR-RNO-210500, Glutamate Neurotransmitter Release Cycle
    R-RNO-352230, Amino acid transport across the plasma membrane
    SABIO-RKiQ9JHE5

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9JHE5

    Gene expression databases

    BgeeiENSRNOG00000006305, Expressed in esophagus and 20 other tissues
    GenevisibleiQ9JHE5, RN

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057, AA_transpt_TM
    PfamiView protein in Pfam
    PF01490, Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS38A2_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JHE5
    Secondary accession number(s): Q9JI88
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 1, 2000
    Last modified: August 12, 2020
    This is version 111 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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