Kat2b

Functionⁱ

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4.By similarity

Catalytic activityⁱ

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N₆-acetyl-L-lysine.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	551	Proton donor/acceptorBy similarity		1

GO - Molecular functionⁱ

acetyltransferase activity
Source: Reactome
Inferred from experimentⁱ
- 11250901
chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16245309
cyclin-dependent protein serine/threonine kinase inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19773423
histone acetyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 15992539
- 9742083
histone acetyltransferase binding Source: MGI
histone deacetylase binding Source: MGI
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
Source: UniProtKB
Inferred from direct assayⁱ
- 19773423
peptide-lysine-N-acetyltransferase activity Source: MGI
protein-containing complex binding Source: MGI
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19773423
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 21402781
transcription coactivator activity
Source: MGI
Inferred from direct assayⁱ
- 15509593
- 15647252
transcription coregulator activity Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cellular response to insulin stimulus Source: MGI
chromatin remodeling Source: UniProtKB
heart development Source: UniProtKB
histone acetylation
Source: MGI
Inferred from direct assayⁱ
- 15992539
histone H3 acetylation Source: MGI
histone H3-K9 acetylation
Source: MGI
Inferred from genetic interactionⁱ
- 24051374
internal peptidyl-lysine acetylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19773423
limb development Source: UniProtKB
negative regulation of cell proliferation Source: MGI
negative regulation of centriole replication Source: UniProtKB
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19773423
N-terminal peptidyl-lysine acetylation Source: MGI
peptidyl-lysine acetylation Source: MGI
positive regulation of blood vessel diameter Source: MGI
positive regulation of chromatin binding Source: MGI
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
Source: MGI
Inferred from genetic interactionⁱ
- 24051374
positive regulation of histone H3-K14 acetylation Source: MGI
positive regulation of histone H3-K9 acetylation Source: MGI
positive regulation of neuron projection development Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 15509593
- 15647252
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 15601857
protein acetylation Source: MGI
regulation of protein ADP-ribosylation Source: MGI
regulation of transcription, DNA-templated
Source: MGI
Traceable author statementⁱ
- 10722926
rhythmic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Acyltransferase, Transferase
Biological process	Biological rhythms, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-MMU-350054 Notch-HLH transcription pathway R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5689901 Metalloprotease DUBs R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-8941856 RUNX3 regulates NOTCH signaling R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5689901 Metalloprotease DUBs
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8941856 RUNX3 regulates NOTCH signaling
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone acetyltransferase KAT2B (EC:2.3.1.48By similarity) Alternative name(s): Histone acetyltransferase PCAF1 Publication Short name: Histone acetylase PCAF1 Publication Lysine acetyltransferase 2BCurated P300/CBP-associated factor1 Publication Short name: P/CAF1 Publication
Gene namesⁱ	Name:Kat2bImported Synonyms:Pcaf1 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1343094 Kat2b

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

No visible phenotype (PubMed:11017084).1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000322986	1 – 813	Histone acetyltransferase KAT2BAdd BLAST		813

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9JHD1
PaxDbⁱ	Q9JHD1
PRIDEⁱ	Q9JHD1

PTM databases

iPTMnetⁱ	Q9JHD1
PhosphoSitePlusⁱ	Q9JHD1

Expressionⁱ

Developmental stageⁱ

Expression is low during embryogenesis and becomes up-regulated in some adult tissues including heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000000708 Expressed in 296 organ(s), highest expression level in stria vascularis of cochlear duct
ExpressionAtlasⁱ	Q9JHD1 baseline and differential
Genevisibleⁱ	Q9JHD1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with BCAS3. Interacts with SIRT1. Interacts with EP300, CREBBP and DDX17. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Interacts with NPAS2, ARNTL/BMAL1 and CLOCK (By similarity). Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity. Interacts with CEBPB (By similarity). Interacts with NR4A3 (PubMed:12709428). Interacts with TBX5 (By similarity). Interacts with PLK4 (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Nr2c1	Q505F1	3	EBI-2325611,EBI-15617004

With

Entry

#Exp.

IntAct

Notes

Nr2c1

Q505F1

3

EBI-2325611,EBI-15617004

GO - Molecular functionⁱ

histone acetyltransferase binding Source: MGI
histone deacetylase binding Source: MGI
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19773423
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202042, 20 interactors
ComplexPortalⁱ	CPX-1024 PCAF histone acetylase complex CPX-1029 PCAF-containing ATAC complex
Database of interacting proteins More...DIPⁱ	DIP-29281N
IntActⁱ	Q9JHD1, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9JHD1
STRINGⁱ	10090.ENSMUSP00000000724

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	707 – 722	Combined sources	16
Helixⁱ	727 – 729	Combined sources	3
Turnⁱ	735 – 737	Combined sources	3
Helixⁱ	741 – 744	Combined sources	4
Helixⁱ	751 – 759	Combined sources	9
Helixⁱ	766 – 783	Combined sources	18
Helixⁱ	789 – 807	Combined sources	19

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9JHD1
SMRⁱ	Q9JHD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	484 – 632	N-acetyltransferasePROSITE-ProRule annotationAdd BLAST		149
Domainⁱ	721 – 791	BromoPROSITE-ProRule annotationAdd BLAST		71

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	555 – 557	Acetyl-CoA bindingBy similarity	3
Regionⁱ	562 – 568	Acetyl-CoA bindingBy similarity	7
Regionⁱ	593 – 596	Acetyl-CoA bindingBy similarity	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	48 – 53	Poly-Gly		6

Sequence similaritiesⁱ

Belongs to the acetyltransferase family. GCN5 subfamily.Curated

Keywords - Domainⁱ

Bromodomain

Phylogenomic databases

eggNOGⁱ	KOG1472 Eukaryota COG5076 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150850
HOGENOMⁱ	HOG000007151
InParanoidⁱ	Q9JHD1
KEGG Orthology (KO) More...KOⁱ	K06062
OMAⁱ	QVIRFPM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ZO
PhylomeDBⁱ	Q9JHD1
TreeFamⁱ	TF105399

Family and domain databases

Gene3Dⁱ	1.20.920.10, 1 hit
InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR037800 GCN5 IPR016376 GCN5/PCAF IPR000182 GNAT_dom IPR009464 PCAF_N
PANTHERⁱ	PTHR22880:SF124 PTHR22880:SF124, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit PF00439 Bromodomain, 1 hit PF06466 PCAF_N, 1 hit
PIRSFⁱ	PIRSF003048 Histone_acetylase_PCAF, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS51186 GNAT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9JHD1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEAGGAGSP ALPPAPPHGS PRTLATAAGS SASCGPATAV AAAGTAEGPG 
        60         70         80         90        100
GGGSARIAVK KAQLRSAPRA KKLEKLGVYS ACKAEESCKC NGWKNPNPSP 
       110        120        130        140        150
TPPRGDLQQI IVSLTESCRS CSHALAAHVS HLENVSEEEM DRLLGIVLDV 
       160        170        180        190        200
EYLFTCVHKE EDADTKQVYF YLFKLLRKSI LQRGKPVVEG SLEKKPPFEK 
       210        220        230        240        250
PSIEQGVNNF VQYKFSHLPS KERQTTIELA KMFLNRINYW HLEAPSQRRL 
       260        270        280        290        300
RSPNDDISGY KENYTRWLCY CNVPQFCDSL PRYETTKVFG RTLLRSVFTI 
       310        320        330        340        350
MRRQLLEQAR QEKDKLPLEK RTLILTHFPK FLSMLEEEVY SQNSPIWDQD 
       360        370        380        390        400
FLSASSRTSP LGIQTVISPP VTGTALFSSN STSHEQINGG RTSPGCRGSS 
       410        420        430        440        450
GLEANPGEKR KMNNSHAPEE AKRSRVMGDI PVELINEVMS TITDPAGMLG 
       460        470        480        490        500
PETNFLSAHS ARDEAARLEE RRGVIEFHVV GNSLNQKPNK KILMWLVGLQ 
       510        520        530        540        550
NVFSHQLPRM PKEYITRLVF DPKHKTLALI KDGRVIGGIC FRMFPSQGFT 
       560        570        580        590        600
EIVFCAVTSN EQVKGYGTHL MNHLKEYHIK HEILNFLTYA DEYAIGYFKK 
       610        620        630        640        650
QGFSKEIKIP KTKYVGYIKD YEGATLMGCE LNPQIPYTEF SVIIKKQKEI 
       660        670        680        690        700
IKKLIERKQA QIRKVYPGLS CFKDGVRQIP IESIPGIRET GWKPSGKEKS 
       710        720        730        740        750
KEPKDPEQLY STLKNILQQV KNHPNAWPFM EPVKRTEAPG YYEVIRFPMD 
       760        770        780        790        800
LKTMSERLRN RYYVSKKLFM ADLQRVFTNC KEYNPPESEY YKCASILEKF 
       810 
FFSKIKEAGL IDK

Length:813

Mass (Da):91,769

Last modified:March 18, 2008 - v2

Checksum:ⁱ38E52F326794F523

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q1F7	E9Q1F7_MOUSE	Histone acetyltransferase KAT2B Histone acetyltransferase KAT2B	Kat2b	211	Annotation score:
F6SIC5	F6SIC5_MOUSE	Histone acetyltransferase KAT2B Histone acetyltransferase KAT2B	Kat2b	118	Annotation score:
F6ZCH1	F6ZCH1_MOUSE	Histone acetyltransferase KAT2B Histone acetyltransferase KAT2B	Kat2b	66	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	293 – 294	LL → FV in AAF70498 (PubMed:9742083).Curated	2
Sequence conflictⁱ	319	E → G in BAE33658 (PubMed:16141072).Curated	1
Sequence conflictⁱ	459	H → L in AAF70498 (PubMed:9742083).Curated	1
Sequence conflictⁱ	548	G → A in AAF70498 (PubMed:9742083).Curated	1
Sequence conflictⁱ	554	F → L in AAF70498 (PubMed:9742083).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF254442 mRNA Translation: AAF70498.1 AK156290 mRNA Translation: BAE33658.1 BC082581 mRNA Translation: AAH82581.1 BC145896 mRNA Translation: AAI45897.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28880.1
NCBI Reference Sequences More...RefSeqⁱ	NP_064389.2, NM_020005.4
UniGeneⁱ	Mm.255025

Genome annotation databases

Ensemblⁱ	ENSMUST00000000724; ENSMUSP00000000724; ENSMUSG00000000708
GeneIDⁱ	18519
KEGGⁱ	mmu:18519
UCSC genome browser More...UCSCⁱ	uc008czp.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JHD1	Histone acetyltransferase		MOUSE		813	UniRef100_Q9JHD1
UPI0003D70A5A		MOUSE		674

Protein	Similar proteins		Species	Score	Length	Source
Q9JHD1	Histone acetyltransferase KAT2B	)	HUMAN		832	UniRef90_Q92831
Histone acetyltransferase		GORGO		799
histone acetyltransferase KAT2B		MESAU		838
Histone acetyltransferase		FELCA		834
Histone acetyltransferase		PONAB		834
+130

Protein	Similar proteins		Species	Score	Length	Source
Q9JHD1	Histone acetyltransferase KAT2B	)	HUMAN		832	UniRef50_Q92831
Histone acetyltransferase KAT2A		MOUSE		830
Histone acetyltransferase KAT2B		DANRE		796
Histone acetyltransferase		GORGO		799
histone acetyltransferase KAT2B		MESAU		838
+850

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF254442 mRNA Translation: AAF70498.1 AK156290 mRNA Translation: BAE33658.1 BC082581 mRNA Translation: AAH82581.1 BC145896 mRNA Translation: AAI45897.1
CCDSⁱ	CCDS28880.1
RefSeqⁱ	NP_064389.2, NM_020005.4
UniGeneⁱ	Mm.255025

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5ML0	X-ray	1.64	A	705-813	[»]
ProteinModelPortalⁱ	Q9JHD1
SMRⁱ	Q9JHD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202042, 20 interactors
ComplexPortalⁱ	CPX-1024 PCAF histone acetylase complex CPX-1029 PCAF-containing ATAC complex
DIPⁱ	DIP-29281N
IntActⁱ	Q9JHD1, 3 interactors
MINTⁱ	Q9JHD1
STRINGⁱ	10090.ENSMUSP00000000724

PTM databases

iPTMnetⁱ	Q9JHD1
PhosphoSitePlusⁱ	Q9JHD1

Proteomic databases

MaxQBⁱ	Q9JHD1
PaxDbⁱ	Q9JHD1
PRIDEⁱ	Q9JHD1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000724; ENSMUSP00000000724; ENSMUSG00000000708
GeneIDⁱ	18519
KEGGⁱ	mmu:18519
UCSCⁱ	uc008czp.2 mouse

Organism-specific databases

CTDⁱ	8850
MGIⁱ	MGI:1343094 Kat2b

Phylogenomic databases

eggNOGⁱ	KOG1472 Eukaryota COG5076 LUCA
GeneTreeⁱ	ENSGT00930000150850
HOGENOMⁱ	HOG000007151
InParanoidⁱ	Q9JHD1
KOⁱ	K06062
OMAⁱ	QVIRFPM
OrthoDBⁱ	EOG091G03ZO
PhylomeDBⁱ	Q9JHD1
TreeFamⁱ	TF105399

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-MMU-350054 Notch-HLH transcription pathway R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5689901 Metalloprotease DUBs R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-8941856 RUNX3 regulates NOTCH signaling R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5689901 Metalloprotease DUBs
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-8941856 RUNX3 regulates NOTCH signaling
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRSⁱ	Kat2b mouse
Protein Ontology More...PROⁱ	PR:Q9JHD1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000708 Expressed in 296 organ(s), highest expression level in stria vascularis of cochlear duct
ExpressionAtlasⁱ	Q9JHD1 baseline and differential
Genevisibleⁱ	Q9JHD1 MM

Family and domain databases

Gene3Dⁱ	1.20.920.10, 1 hit
InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR037800 GCN5 IPR016376 GCN5/PCAF IPR000182 GNAT_dom IPR009464 PCAF_N
PANTHERⁱ	PTHR22880:SF124 PTHR22880:SF124, 1 hit
Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit PF00439 Bromodomain, 1 hit PF06466 PCAF_N, 1 hit
PIRSFⁱ	PIRSF003048 Histone_acetylase_PCAF, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS51186 GNAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KAT2B_MOUSE
Accessionⁱ	Q9JHD1Primary (citable) accession number: Q9JHD1 Secondary accession number(s): Q3U142, Q640M9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9JHD1 (KAT2B_MOUSE)

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Histone acetyltransferase KAT2B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ