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Entry version 99 (07 Apr 2021)
Sequence version 2 (13 Jun 2006)
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Protein

Non-structural polyprotein p200

Gene
N/A
Organism
Rubella virus (strain Cendehill) (RUBV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable principal replicase for the negative-strand DNA, which replicates the 40S (+) genomic RNA into (-) antigenomic RNA. It cannot replicate the (-) into (+) until cleaved into p150 and p90 mature proteins.By similarity
Protease that cleaves the precursor polyprotein into two mature products. Together with RNA-directed RNA polymerase p90, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. Responsible for the mRNA-capping of the viral mRNAs. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. Forms fibers late in the infection that may be involved in cell-to-cell spread of the virus RNA in the absence of virus particle formation.By similarity
Together with protease/methyltransferase p150, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. A helicase activity is probably also present.By similarity

Miscellaneous

Rubella virus in utero infection has frequently severe consequences on normal fetal development, collectively known as congenital rubella syndrome (CRS). The teratogenicity of the virus is possibly due to the interaction between the p90 protein and the human RB1/retinoblastoma protein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationNote: Zn2+ is necessary for the protease activity. The protease can also function efficiently with Cd2+ and Co2+.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1152For cysteine protease activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1175ZincPROSITE-ProRule annotation1
Metal bindingi1178ZincPROSITE-ProRule annotation1
Metal bindingi1227ZincPROSITE-ProRule annotation1
Active sitei1273For cysteine protease activityPROSITE-ProRule annotation1
Metal bindingi1273ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1352 – 1359NTPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C27.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-structural polyprotein p200
Short name:
p200
Cleaved into the following 2 chains:
Protease/methyltransferase p150 (EC:3.4.22.-)
Short name:
p150
RNA-directed RNA polymerase p90 (EC:2.7.7.48PROSITE-ProRule annotation, EC:3.6.1.15, EC:3.6.4.13)
Short name:
p90
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRubella virus (strain Cendehill) (RUBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri376266 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaAlsuviricetesHepeliviralesMatonaviridaeRubivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008176 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002401671 – 2116Non-structural polyprotein p200Add BLAST2116
ChainiPRO_00002401681 – 1301Protease/methyltransferase p150Add BLAST1301
ChainiPRO_00002401691302 – 2116RNA-directed RNA polymerase p90Add BLAST815

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1301 – 1302Cleavage; autocatalyticPROSITE-ProRule annotation2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNA-directed RNA polymerase p90.

Interacts with host CALM1; this interaction is necessary for the protease activity and viral infectivity.

Interacts with host C1QBP.

Interacts with the capsid protein.

Curated

Interacts with human RB1/retinoblastoma protein.

Interacts with protease/methyltransferase p150.

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 247Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST191
Domaini806 – 985MacroPROSITE-ProRule annotationAdd BLAST180
Domaini1000 – 1301Peptidase C27PROSITE-ProRule annotationAdd BLAST302
Domaini1320 – 1468(+)RNA virus helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST149
Domaini1469 – 1609(+)RNA virus helicase C-terminalPROSITE-ProRule annotationAdd BLAST141
Domaini1870 – 1981RdRp catalyticPROSITE-ProRule annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 49Required for efficient proteolysis and P150-P90 interactionBy similarityAdd BLAST14
Regioni1152 – 1183Interaction with host CALM1PROSITE-ProRule annotationAdd BLAST32
Regioni1193 – 1228EF-hand-likePROSITE-ProRule annotationAdd BLAST36
Regioni1700 – 1900Involved in P150-P90 interactionBy similarityAdd BLAST201

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi727 – 732PxxPxR; class II SH3-bindingBy similarity6
Motifi747 – 752PxxPxR; class II SH3-bindingBy similarity6
Motifi761 – 766PxxPxR; class II SH3-bindingBy similarity6
Motifi1902 – 1906Human RB1 bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus has a methyltransferase activity for mRNA-capping. The C-terminus harbors a protease active in cis or in trans which specifically cleaves and releases the two mature proteins. Both the N-terminus and C-terminus are required for fiber formation. The N-terminus is involved in associating with membranes. An EF-hand Ca2+-binding motif is present in the protease. Also contains 3 SH3-binding motifs that are responsible for the interaction with host C1QBP.By similarity

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21557, Macro_X_Nsp3-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR027417, P-loop_NTPase
IPR008738, Peptidase_C27
IPR007094, RNA-dir_pol_PSvirus
IPR022245, Rubi_NSP_C
IPR044070, RUBV_NS_PRO
IPR001788, Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01661, Macro, 1 hit
PF05407, Peptidase_C27, 1 hit
PF00978, RdRP_2, 1 hit
PF12601, Rubi_NSP_C, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51889, RUBV_NS_PRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9J6K9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLLDEVLA PGGPYNLTVG SWVRDHVRSI VEGAWEVRDV VTAAQKRAIV
60 70 80 90 100
AVIPRPVFTQ MQVSDHPALH AISRYTRRHW IEWGPKEALH VLIDPSPGLL
110 120 130 140 150
REVARVERRW VALCLHRTAR KLATALAETA SEAWHADYVC ALRGAPSGPF
160 170 180 190 200
YVHPEDVPHG GRAVADRCLL YYTPMQMCEL MRTIDATLLV AVDLWPVALA
210 220 230 240 250
AHVGDDWDDL GIAWHLDHDG GCPADCRGAG AGPTPGYTRP CTTRIYQVLP
260 270 280 290 300
DTAHPGRLYR CGPRLWTRDC AVAELSWEVA QHCGHQARVR AVRCTLPIRH
310 320 330 340 350
VRSLQPSARV RLPDLVHLAE VGRWRWFSLP RPVFQRMLSY CKTLSPDAYY
360 370 380 390 400
SERVFKFKNA LSHSITLAGN VLQEGWKGTC AEEDALCAYV AFRAWQSNAR
410 420 430 440 450
LAGIMKGAKR CAADSLSVAG WLDTIWDAIK RFFGSVPLAE RMEEWEQDAA
460 470 480 490 500
VAAFDRGPLE DGGRHLDTVQ PPKSPPRPEI AATWIVHAAS ADRHCACAPR
510 520 530 540 550
CDVPRERPSA PAGQPDDEAL IPPWLFAERR ALRCREWDFE ALRARADTAA
560 570 580 590 600
APAPLAPRPA RYPTVLYRHP AHHGPWLTLD EPGEADAALV LCDPLGQPLR
610 620 630 640 650
GPERHFAAGA HMCAQARGLQ AFVRVVPPPE RPWADGGARA WAKFFRGCAW
660 670 680 690 700
AQRLLGEPAV MHLPYTDGDV PQLIALALRT LAQQGAALAL SVRDLPGGAA
710 720 730 740 750
FDANAVTAAV RAGPGQLAAT SPPPGDPPPP RRARRSQRHS DARGTPPPAP
760 770 780 790 800
VRDPPPPAPS PPAPPRAGDP VPPTPAEPAD RARDAELEVA YEPSGPPTST
810 820 830 840 850
KADPDSDIVE SYARAAGPVH LRVRDIMDPP PGCKVVVNAA NEGLLAGSGV
860 870 880 890 900
CGAIFANATA ALAADCRRLA PCPTGEAVAT PGHGCGYTHI IHAVAPRRPR
910 920 930 940 950
DPAALEEGEA LLERAYRSIV ALAAARRWAY VACPLLGAGV YGWSAAESLR
960 970 980 990 1000
AALAATRAEP VERVSLHICH PDRATLTHAS VLVGAGLAAR RVSPPPTEPL
1010 1020 1030 1040 1050
ASCPAGGPGR PAQRSASPPA TPLGDATAPE PRGCQGCELC RHTRVTNDRA
1060 1070 1080 1090 1100
YVNLWLERDR GATSWAMRIP EVVVYGPEHL ATHFPLNHYS VLKPAEVRPP
1110 1120 1130 1140 1150
RGMCGSDMWR CRGWQGMPQV RCTPSNAHAA LCRTGVPPRV STRGGELDPN
1160 1170 1180 1190 1200
TCWLRAAANV AQVARACGAY TSAGCPKCAY GRALSEARTH EDFAALSQRW
1210 1220 1230 1240 1250
SASHADASPD GTGDPLDPLM ETVGCACSRV WVGSEQEAPP DHLLVSLHRA
1260 1270 1280 1290 1300
PNGPWGVVLE VRARPEGGNP TGHFVCAVGG GPRRVSDRPH LWLAVPLSRG
1310 1320 1330 1340 1350
GGTCAATDEG LAQAYYDDLE VRRLGDDAMA RAALASVQRP RKGPYNIRVW
1360 1370 1380 1390 1400
NMAAGAGKTT RILAAFTRED LYVCPTNALL HEIQAKLRAR DIDIKNAATY
1410 1420 1430 1440 1450
ERALTKPLAA YRRIYIDEAF TLGGEYCAFV ASQTTAEVIC VGDRDQCGPH
1460 1470 1480 1490 1500
YANNCRTPVP DRWPTERSRH TWRFPDCWAA RLRAGLDYDI EGERTGIFAC
1510 1520 1530 1540 1550
NLWDGRQVDL HLAFSRETVR RLHEAGIRAY TVREAQGMSV GTACIHVGRD
1560 1570 1580 1590 1600
GTDVALALTR DLAIVSLTRA SDALYLHELE DGSLRAAGLS AFLDAGALAE
1610 1620 1630 1640 1650
LKEVPAGIDR VVAVEQAPPP LPPADGIPEA QDVPPFCPRT LEELVFGRAG
1660 1670 1680 1690 1700
HPHYADLNRV TEGEREVRYM RISRHLLNKN HTEMPGTERV LSAVCAVRRY
1710 1720 1730 1740 1750
RAGEDGSTLR TAVARQHPRP FRQIPPPRVT AGVAQEWRMT YLRERIDLTD
1760 1770 1780 1790 1800
VYTQMGVAAR ELTDRYARRY PEIFAGMCTA QSLSVPAFLK ATLKCVDAAL
1810 1820 1830 1840 1850
GPRDTEDCHA AQGKAGLEIR AWAKEWVQVM SPHFRAIQKI IMRALRPQFL
1860 1870 1880 1890 1900
VAAGHTEPEV DAWWQAHYTT NAIEVDFTEF DMNQTLATRD VELEISAALL
1910 1920 1930 1940 1950
GLPCAEDYRA LRAGSYCTLR ELGSTETGCE RTSGEPATLL HNTTVAMCMA
1960 1970 1980 1990 2000
MRMVPKGVRW AGIFQGDDMV IFLPEGARSA ALKWTPAEVG LFGFHIPVKH
2010 2020 2030 2040 2050
VSTPTPSFCG HVGTAAGLFH DVMHQAIKVL CRRFDPDVLE EQQVALLDRL
2060 2070 2080 2090 2100
RGVYAALPDT VAANAAYYDY SAERVLAIVR ELTAYARGRG LDHPATIGAL
2110
EEIQTPYARA NLHDAD
Length:2,116
Mass (Da):230,510
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i069DCB15BB9D5E56
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF26709 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF188704 Genomic RNA Translation: AAF26709.1 Different initiation.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188704 Genomic RNA Translation: AAF26709.1 Different initiation.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC27.001

Family and domain databases

CDDicd21557, Macro_X_Nsp3-like, 1 hit
Gene3Di3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR027417, P-loop_NTPase
IPR008738, Peptidase_C27
IPR007094, RNA-dir_pol_PSvirus
IPR022245, Rubi_NSP_C
IPR044070, RUBV_NS_PRO
IPR001788, Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF01661, Macro, 1 hit
PF05407, Peptidase_C27, 1 hit
PF00978, RdRP_2, 1 hit
PF12601, Rubi_NSP_C, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51154, MACRO, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51889, RUBV_NS_PRO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLN_RUBVD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9J6K9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: April 7, 2021
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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