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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Nodamura virus (strain Mag115) (NoV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiNodamura virus (strain Mag115) (NoV)
Taxonomic identifieri914672 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiAedes [TaxID: 7158]
Lepidoptera (butterflies and moths) [TaxID: 7088]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000166289 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002224481 – 1043RNA-directed RNA polymeraseAdd BLAST1043

Structurei

3D structure databases

ProteinModelPortaliQ9IMM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini588 – 713RdRp catalyticPROSITE-ProRule annotationAdd BLAST126

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated

Phylogenomic databases

OrthoDBiVOG090002L9

Family and domain databases

InterProiView protein in InterPro
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00680 RdRP_1, 1 hit
PROSITEiView protein in PROSITE
PS50507 RDRP_SSRNA_POS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform RNA-directed RNA polymerase (identifier: Q9IMM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNYETIING ASSALNIVSR ALGYRVPLAK SLALVAGSCV VYKIIVHRRT
60 70 80 90 100
LVAFLVIGPY ATVVQHRLPM ALQRAIIEYT REDREISLFP QNSIVSAEHA
110 120 130 140 150
RKADNGHPIS GGTRDVARET ISLAIRAAGF RHYEISPARQ SPAEAASHQH
160 170 180 190 200
YAAADLVRAA TEDKIQDGDV VVAIDIDYYL RDIDRYLGRG VPFMAYTFNP
210 220 230 240 250
VEVAGRDGDS FFRITNNQVT FDVSGGGSWS HEVWDWCAFG EFIETRDASW
260 270 280 290 300
LAWFARAVGL TKSQIHKVHY CRPWPQSPHR ALVWCLPVAS YWRFTFIPTD
310 320 330 340 350
LHTRTLRRVR YQDTSRPGWN SIVSTGSEGL NISLGREGAD HCVTIPKVHY
360 370 380 390 400
DMLMGLSSAQ SLSSRMIGLK YTDPSVLATV AQYYQGKNVE VADADRIGRA
410 420 430 440 450
INPKVHWPAH VEVDEAEVSA RVYASPLVSD ENMMPMIKRW ETLSLSLDRR
460 470 480 490 500
VTFQRNPKVP GKRLRAYAIE FVDLVVPERG VGVPYSLEDT AAMLDKPSQT
510 520 530 540 550
LAIQQVWETV DMPPRRLIEA FVKNEPTMKA GRIISSFADM RFLLRFSSYT
560 570 580 590 600
LAFRDQVLHA EHNRHWFCPG LTPEQIATKV VDYVSGVEEP SEGDFSNFDG
610 620 630 640 650
TVSEWLQRHV MNAVYLRYFN HRAQRDLRSY TDMLVSCPAR AKRFGFAYDA
660 670 680 690 700
GVGVKSGSPT TCDLNTVCNG FLQYCSIRMT HPELTPIDAF RLIGLAFGDD
710 720 730 740 750
SLFERRFAKN YAKVSAEVGM VLKIERFDPA QGITFLARVY PDPYTSTTSF
760 770 780 790 800
QDPLRTWRKL HLTTRDPTIP LATAAIDRVE GYLVTDGLSP LTGAYCRMVK
810 820 830 840 850
RVYEAGGAED AAKRRSRKSH SREKPYWLTV GGAWPQDVKD VDLMFQCAAA
860 870 880 890 900
RTGVDLETLR SLDQRLGEIT DVWADITINR DNEPNPYKDT LDLEGPADGR
910 920 930 940 950
VDDRVFQNDK HVMRLRANQV TSSQAGAAGS GDASNDPNAH DRGSQRQQGS
960 970 980 990 1000
ASVLRVPDRA APAGVSSDEQ PAHQTASRSS ASRGGAGPGR GGRRRPGPPA
1010 1020 1030 1040
KTTAGGARDG NQARAPTSGP SKRQAEGRSR SSRGPAGSRG RGK
Length:1,043
Mass (Da):115,774
Last modified:October 1, 2000 - v1
Checksum:i0DF0CBDB5DBF3EBB
GO
Isoform B1 (identifier: Q9IMM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Note: Produced by alternative initiation at Met-913 of isoform 1.
Show »
Length:131
Mass (Da):13,089
Checksum:i5A2F43D064CAEE53
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402831 – 912Missing in isoform B1. CuratedAdd BLAST912

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174533 Genomic RNA Translation: AAF97860.1
RefSeqiNP_077730.1, NC_002690.1

Genome annotation databases

GeneIDi962117
KEGGivg:962117

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiRDRP_NODAM
AccessioniPrimary (citable) accession number: Q9IMM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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