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Entry version 86 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Kielin/chordin-like protein

Gene

kcp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.1 Publication

Miscellaneous

'Kiel' means keel in English. As the expression in the central nervous system (CNS) resembled a keel of ship, the gene was named Kielin.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kcp
Synonyms:crim2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-865639, kcp.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031858820 – 2327Kielin/chordin-like proteinAdd BLAST2308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2016 ↔ 2024PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression starts at the mid-gastrula stage in the dorsal midline. Expressed in the axial mesoderm at this stage. At neurula stages, expression is detected both in the axial mesoderm (notochord and prechordal mesoderm) and in the ventral central nervous system (floor plate and ventral forebrain). At tailbud stages, expression is diminished in the notochord and remains in the ventral central nervous system (CNS). During and after tailbud stages, other regions shows detectable levels of expression. The epiphyseal placode has a strong expression. Additional expression is found in dorsal parts of the CNS, especially in the anterior spinal cord and hindbrain as well as in the tailbud mesoderm. At the larval stage, expression is also found in the forming heart. Induced in mesoderm and in ectoderm by nodal-related genes.1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini339 – 400VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini401 – 438VWFC 2PROSITE-ProRule annotationAdd BLAST38
Domaini439 – 493VWFC 3PROSITE-ProRule annotationAdd BLAST55
Domaini494 – 553VWFC 4PROSITE-ProRule annotationAdd BLAST60
Domaini554 – 610VWFC 5PROSITE-ProRule annotationAdd BLAST57
Domaini611 – 669VWFC 6PROSITE-ProRule annotationAdd BLAST59
Domaini670 – 728VWFC 7PROSITE-ProRule annotationAdd BLAST59
Domaini729 – 786VWFC 8PROSITE-ProRule annotationAdd BLAST58
Domaini787 – 847VWFC 9PROSITE-ProRule annotationAdd BLAST61
Domaini848 – 907VWFC 10PROSITE-ProRule annotationAdd BLAST60
Domaini908 – 966VWFC 11PROSITE-ProRule annotationAdd BLAST59
Domaini967 – 1025VWFC 12PROSITE-ProRule annotationAdd BLAST59
Domaini1026 – 1083VWFC 13PROSITE-ProRule annotationAdd BLAST58
Domaini1084 – 1142VWFC 14PROSITE-ProRule annotationAdd BLAST59
Domaini1146 – 1203VWFC 15PROSITE-ProRule annotationAdd BLAST58
Domaini1204 – 1260VWFC 16PROSITE-ProRule annotationAdd BLAST57
Domaini1261 – 1319VWFC 17PROSITE-ProRule annotationAdd BLAST59
Domaini1321 – 1377VWFC 18PROSITE-ProRule annotationAdd BLAST57
Domaini1378 – 1439VWFC 19PROSITE-ProRule annotationAdd BLAST62
Domaini1440 – 1495VWFC 20PROSITE-ProRule annotationAdd BLAST56
Domaini1496 – 1555VWFC 21PROSITE-ProRule annotationAdd BLAST60
Domaini1556 – 1614VWFC 22PROSITE-ProRule annotationAdd BLAST59
Domaini1615 – 1673VWFC 23PROSITE-ProRule annotationAdd BLAST59
Domaini1674 – 1731VWFC 24PROSITE-ProRule annotationAdd BLAST58
Domaini1732 – 1799VWFC 25PROSITE-ProRule annotationAdd BLAST68
Domaini1800 – 1860VWFC 26PROSITE-ProRule annotationAdd BLAST61
Domaini1861 – 1924VWFC 27PROSITE-ProRule annotationAdd BLAST64
Domaini1928 – 1988VWFC 28PROSITE-ProRule annotationAdd BLAST61
Domaini1993 – 2205VWFDPROSITE-ProRule annotationAdd BLAST213
Domaini2259 – 2319TILAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili291 – 332Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi283 – 286Poly-Gln4
Compositional biasi2163 – 2166Poly-Ser4

Keywords - Domaini

Coiled coil, Repeat, Signal

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001791, Laminin_G
IPR036084, Ser_inhib-like_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00093, VWC, 16 hits
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 1 hit
SM00210, TSPN, 1 hit
SM00214, VWC, 28 hits
SM00215, VWC_out, 12 hits
SM00216, VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF57567, SSF57567, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01208, VWFC_1, 20 hits
PS50184, VWFC_2, 23 hits
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9IBG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTLLWTILL PLLFSFCVCQ QPEHQDLEMS VQYYDDNVID LLEALNVTRS
60 70 80 90 100
VKGVTKAKGS DPASPAWKFR QRVPHLTLPR DYSVYLLSTT QESLGLHFVA
110 120 130 140 150
KQAKNNRGTL VAFLSPAATK IDGRPLLRLI SDTHTDQLYF EYRTAQTMEP
160 170 180 190 200
ASLHFPGSSP FSGSQWARVA LNVNTHKVTL FLDCEEPVVF GKEGAEEMLS
210 220 230 240 250
LILPLDLEIT FASTPSDKES KFLGYWQTAE ISPTGFTRRP WHCENRSDSL
260 270 280 290 300
PLPYSLSGER QMEDEEIQRE PRAPDLSDTD HYQQQQSEVP AQLLAKDDRL
310 320 330 340 350
QRLEEAVKGL TNMIDMIKSQ NADLQARVIA LESCECRRST CVWEDKEYQD
360 370 380 390 400
SETWKKDACN ICVCVGGSVT CSVRKDWPQC LGCFHEGRNY NNKDIFSVGP
410 420 430 440 450
CMSCICQSGE VSCTPKLCPP VTCSDPVTLP NECCPLCATG CSDGHKEGDT
460 470 480 490 500
WRKDTCTTCT CQNGTISCER EQCPELTCLK RHTPPGQCCA KCQQGCEYEG
510 520 530 540 550
LIYRNGDYFL SQSNPCVNCS CLNNLVRCLP VQCPLPACTN PVPIPGQCCP
560 570 580 590 600
SCPVCELDGH PLIPGQNVTT KDGCRLCSCQ DGKVQCTESV QCPHICTHGV
610 620 630 640 650
RSNSCCLDCS ACEMHGDIIP NGLTFQGNMD PCESCTCQDG NVHCVRVSCP
660 670 680 690 700
ELSCVLHEKI PGECCSQCQS CMDGTVKRKH GEEWKPQGDP CQSCRCLEGR
710 720 730 740 750
VQCRKRHCAA LCRNPLPPRP GTCCPMCDGC LYNGRSYLNG QPVRSTDQCN
760 770 780 790 800
RCFCENGNVQ CEPIACPQAP CRNPVRRTGE CCPRCEGCEY DSRHFAEGVV
810 820 830 840 850
FTTAHDPCLQ CTCLSGEVSC EHLDRKCPPS QCSHPGKAAG QCCPSCDVCD
860 870 880 890 900
FEGILYTDRQ TFQPPGHGPC LKCFCTIGNV RCVEETCPPA PCPNPVRDPE
910 920 930 940 950
QCCPVCKVCV QDGVEFLEGI EWELDGNPCS SCTCRNGDTV CGVSECPPVS
960 970 980 990 1000
CLHPTRREGE CCPVCDSCSY NQRLYSNEQI FTDPDNPCQD CQCKDGTVQC
1010 1020 1030 1040 1050
SSIVCPPVLC TIPERTPGQC CAKCPDCRYQ DQIFLEGEQF SNPLNQCQEC
1060 1070 1080 1090 1100
WCRDGHVTCT DRGCTGALCS YPLPGTCCQN NCNGCNYAGK EYPNGADFPH
1110 1120 1130 1140 1150
PTDKCRQCHC INGNVQCLAQ RCPPLLCAEP FPVPGECCPQ CPVPPADCPY
1160 1170 1180 1190 1200
SGVTYRHMQR FYDPSDKCRD CICNNGTVTC QRKPCAPTPC LHPLQGDCCR
1210 1220 1230 1240 1250
SCDGCLMSGK ELANGEQFPQ PSDPCSVCVC WEGSVTCQPK TCPVLNCPFP
1260 1270 1280 1290 1300
APGQCCKECQ DCQYFGEVYL NGQEFSAPED SCSRCVCADG FVTCSKKPCY
1310 1320 1330 1340 1350
KAGCTHPSTP PGKCCPVCDG CSYNGDALIN SQSVPDPSNP LCSECTCRAG
1360 1370 1380 1390 1400
SVQCVRKLCG PTSCPHPVTG PCDCPICQGC HFQGHNYIDG EVFTSAQSQC
1410 1420 1430 1440 1450
EQCRCMRGHV TCGPRPCDQV TCPHPAEDPC MCPVCDGCNY SGRDCTNGES
1460 1470 1480 1490 1500
FPDPEDECSH CTCRNGEVAC ISVPCPRVSC MYPITPRGEC CPRCTGICKH
1510 1520 1530 1540 1550
NGRVYQSGDT FHPPGDLCTK CSCQNEMVNC QRVRCSQECS HPVLSPASSC
1560 1570 1580 1590 1600
CPVCDRCFYE NREYANHETF TSTSDPCQRC VCLDGSVTCT HVVCPYVSCA
1610 1620 1630 1640 1650
NPITKPGQCC RECPVCRYQG KEFSEGAHWV PHTDPCLKCT CSNGHVDCEP
1660 1670 1680 1690 1700
PQCPPLPCTQ QVTDPGTCCP RCRGCVYNGR EYRDNSNWLS SSDHCMSCMC
1710 1720 1730 1740 1750
VDGVTTCSKL QCITSCTNQI TIPGECCPVC ADCISNSKVY LPGDSYNPSK
1760 1770 1780 1790 1800
DPCEICTCES LPNGQQYRHC TKKQCPSLLD CPRSYILPPA EGQCCSSCAQ
1810 1820 1830 1840 1850
ALSNCTNTLV GNEIQATDDP CYTCHCKDLT WVCVHQPCPA LSCPRSEQFT
1860 1870 1880 1890 1900
HSGSCCPVCN ECVVEIEGRR VPDGETWTDR QDPCVTCTCT LGHVECQIEE
1910 1920 1930 1940 1950
CQPVQCQEGE RKVKRPGTCC HECQASAVSC WYQGQRFLSN EHWQVDECTA
1960 1970 1980 1990 2000
CTCVSGEVHC HSERCPQVSC TAEETPALIP GMCCPHCIPR PATCIAFGDP
2010 2020 2030 2040 2050
HYRTFDGKMY HFQGSCTYVL SEDCEGGDFS IHVTNDDRGL RGVSWTKEVT
2060 2070 2080 2090 2100
VLIGDAVVQL LQDWVVMVDY QTVELPFLKE PYIYIERKTN TILLNSNIGV
2110 2120 2130 2140 2150
KVQWNGRSHL EVSVPGTYRD HLCGLCGNFN NYPQDDLRDR RGQILMSEAA
2160 2170 2180 2190 2200
FGNSWRVQSS NDSSSSCWDG QDVDPCKQAG YRARKEANGR CKLLKSSVFE
2210 2220 2230 2240 2250
PCHRVVPPEM FFASCVYDLC ACGAGDECLC DVLEAYASEC REAGVILQWR
2260 2270 2280 2290 2300
SPALCAVGCP HDRGYVFDEC GPPCPKTCFN KDVPLGVLES HCFKPCVPGC
2310 2320
QCPAGLVEHE SHCIPPESCP KIIHGNL
Length:2,327
Mass (Da):255,802
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0293109329209983
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026192 mRNA Translation: BAA95483.1

NCBI Reference Sequences

More...
RefSeqi
NP_001079355.1, NM_001085886.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
378806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:378806

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026192 mRNA Translation: BAA95483.1
RefSeqiNP_001079355.1, NM_001085886.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi378806
KEGGixla:378806

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
378806
XenbaseiXB-GENE-865639, kcp.L

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001791, Laminin_G
IPR036084, Ser_inhib-like_sf
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF00093, VWC, 16 hits
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00832, C8, 1 hit
SM00210, TSPN, 1 hit
SM00214, VWC, 28 hits
SM00215, VWC_out, 12 hits
SM00216, VWD, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF57567, SSF57567, 1 hit
PROSITEiView protein in PROSITE
PS01208, VWFC_1, 20 hits
PS50184, VWFC_2, 23 hits
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCP_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9IBG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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