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UniProtKB - Q9IAT6 (DLLC_DANRE)
Protein
Delta-like protein C
Gene
dlc
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
1 PublicationGO - Molecular functioni
- calcium ion binding Source: InterPro
- identical protein binding Source: ZFIN
- Notch binding Source: GO_Central
- PDZ domain binding Source: ZFIN
GO - Biological processi
- arterial endothelial cell differentiation Source: ZFIN
- blood vessel morphogenesis Source: ZFIN
- dorsal aorta development Source: ZFIN
- hematopoietic progenitor cell differentiation Source: ZFIN
- hematopoietic stem cell differentiation Source: ZFIN
- negative regulation of Notch signaling pathway Source: GO_Central
- neuron development Source: ZFIN
- Notch signaling pathway Source: ZFIN
- sclerotome development Source: ZFIN
- somite specification Source: ZFIN
- somitogenesis Source: ZFIN
- ventral spinal cord interneuron differentiation Source: ZFIN
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Notch signaling pathway |
Ligand | Calcium |
Enzyme and pathway databases
SignaLinki | Q9IAT6 |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-like protein CShort name: DeltaC Short name: delC |
Gene namesi | Name:dlc |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-000125-4, dlc |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- plasma membrane Source: ZFIN
Other locations
- cytoplasm Source: ZFIN
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: ZFIN
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 511 | ExtracellularSequence analysisAdd BLAST | 491 | |
Transmembranei | 512 – 532 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 533 – 664 | CytoplasmicSequence analysisAdd BLAST | 132 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000007516 | 21 – 664 | Delta-like protein CAdd BLAST | 644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 156 ↔ 165 | By similarity | ||
Disulfide bondi | 169 ↔ 181 | By similarity | ||
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 189 ↔ 198 | By similarity | ||
Disulfide bondi | 203 ↔ 214 | By similarity | ||
Disulfide bondi | 207 ↔ 220 | By similarity | ||
Disulfide bondi | 222 ↔ 231 | By similarity | ||
Disulfide bondi | 234 ↔ 245 | By similarity | ||
Disulfide bondi | 240 ↔ 251 | By similarity | ||
Disulfide bondi | 253 ↔ 262 | By similarity | ||
Disulfide bondi | 269 ↔ 281 | By similarity | ||
Disulfide bondi | 275 ↔ 291 | By similarity | ||
Disulfide bondi | 293 ↔ 302 | By similarity | ||
Disulfide bondi | 309 ↔ 320 | By similarity | ||
Disulfide bondi | 314 ↔ 329 | By similarity | ||
Disulfide bondi | 331 ↔ 340 | By similarity | ||
Disulfide bondi | 347 ↔ 358 | By similarity | ||
Disulfide bondi | 352 ↔ 368 | By similarity | ||
Disulfide bondi | 370 ↔ 379 | By similarity | ||
Disulfide bondi | 386 ↔ 397 | By similarity | ||
Disulfide bondi | 391 ↔ 406 | By similarity | ||
Disulfide bondi | 408 ↔ 417 | By similarity | ||
Disulfide bondi | 424 ↔ 435 | By similarity | ||
Disulfide bondi | 429 ↔ 444 | By similarity | ||
Disulfide bondi | 446 ↔ 455 | By similarity | ||
Disulfide bondi | 462 ↔ 473 | By similarity | ||
Disulfide bondi | 467 ↔ 482 | By similarity | ||
Disulfide bondi | 484 ↔ 493 | By similarity |
Post-translational modificationi
Ubiquitinated by mib, leading to its endocytosis and subsequent degradation.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9IAT6 |
PRIDEi | Q9IAT6 |
Expressioni
Tissue specificityi
Strongly expressed in the early retina, where it precedes other delta proteins. Also expressed in cranial ganglia, in sensory epithelia including ear and lateral line and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly; it is expressed subsequently in the tail bud, in stripes in the presomitic mesoderm and in the posterior half of each somite. Also expressed in notochord, blood vessels and pronephros. In contrast to other delta proteins, it is not expressed in the majority of nascent primary neurons. In somites, it marks the posterior part of each formed somite, while deltaD (dld) marks the anterior part.1 Publication
Interactioni
GO - Molecular functioni
- identical protein binding Source: ZFIN
- Notch binding Source: GO_Central
- PDZ domain binding Source: ZFIN
Protein-protein interaction databases
BioGRIDi | 78356, 3 interactors |
STRINGi | 7955.ENSDARP00000018643 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 154 – 198 | DSLPROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 199 – 232 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 233 – 263 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 265 – 303 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 305 – 341 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 343 – 380 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 382 – 418 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 420 – 456 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 458 – 494 | EGF-like 8PROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
InParanoidi | Q9IAT6 |
OrthoDBi | 406049at2759 |
PhylomeDBi | Q9IAT6 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR024731, EGF_dom IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 4 hits PF12947, EGF_3, 1 hit PF12661, hEGF, 1 hit |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 8 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS51051, DSL, 1 hit PS00022, EGF_1, 8 hits PS01186, EGF_2, 8 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9IAT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARVLLTCFF ILISSHLGKS SGVFELKVLS FTSTSSVCKG SSDCQIFFRV
60 70 80 90 100
CLKHSQALIL PEPPCTYGTG MSEILSADSI SSSAYISVPF NFKWPGIVSL
110 120 130 140 150
IIETWNAETS DQSTENNNNM ISRLATKRRL AISEDWSQDV HLGRQSQLRF
160 170 180 190 200
SYRVVCDEFY HGEECSDFCR PRNDTFGHFN CDAAGNRICL PGWKGDYCTE
210 220 230 240 250
PICLSGCSEE NGYCEAPGEC KCRIGWEGPL CDECTRHPGC LHGTCNQPFQ
260 270 280 290 300
CTCKEGWGGL FCNEDLNFCT NHKPCRNDAT CTNTGQGSYT CICKPGFSGK
310 320 330 340 350
NCEIETNECD SNPCKNGGSC NDQENDYTCT CPQGFYGKNC EVSAMTCADG
360 370 380 390 400
PCFNGGTCME KGSGSYSCRC PPGYMGSNCE KKIDRCSSDP CANGGQCLDL
410 420 430 440 450
GNKATCRCRP GFTGSRCETN IDDCSSNPCQ NAGTCVDGIN GYTCTCTLGF
460 470 480 490 500
SGKDCRVRSD ACSFMPCQNG GTCYTHFSGP VCQCPAGFMG TQCEYKQKPT
510 520 530 540 550
PVNSPALPAA LIVSFTLGLI TLTLVICAAI VVLRQMRQNH KASSTTVRNN
560 570 580 590 600
LDSVNNRISL SPTSPLGREK EAFLIPGGPF KVSNKDMALR STSVDTHSSD
610 620 630 640 650
KSNYKQKMVD YNLSIDEKHT NNKLEKNSES TLLVPPLNYP KEGVYHPVYI
660
IPEHIEQRVF ATEV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB3DFM3 | B3DFM3_DANRE | Delta-like protein | dlc | 664 | Annotation score: | ||
A0A2R8QUE3 | A0A2R8QUE3_DANRE | Delta-like protein | dlc | 677 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF146429 mRNA Translation: AAF27299.1 |
RefSeqi | NP_571019.1, NM_130944.1 |
Genome annotation databases
GeneIDi | 30120 |
KEGGi | dre:30120 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF146429 mRNA Translation: AAF27299.1 |
RefSeqi | NP_571019.1, NM_130944.1 |
3D structure databases
AlphaFoldDBi | Q9IAT6 |
SMRi | Q9IAT6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 78356, 3 interactors |
STRINGi | 7955.ENSDARP00000018643 |
Proteomic databases
PaxDbi | Q9IAT6 |
PRIDEi | Q9IAT6 |
Genome annotation databases
GeneIDi | 30120 |
KEGGi | dre:30120 |
Organism-specific databases
CTDi | 30120 |
ZFINi | ZDB-GENE-000125-4, dlc |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
InParanoidi | Q9IAT6 |
OrthoDBi | 406049at2759 |
PhylomeDBi | Q9IAT6 |
Enzyme and pathway databases
SignaLinki | Q9IAT6 |
Miscellaneous databases
PROi | PR:Q9IAT6 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR024731, EGF_dom IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 4 hits PF12947, EGF_3, 1 hit PF12661, hEGF, 1 hit |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 8 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS51051, DSL, 1 hit PS00022, EGF_1, 8 hits PS01186, EGF_2, 8 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DLLC_DANRE | |
Accessioni | Q9IAT6Primary (citable) accession number: Q9IAT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |