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Entry version 116 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Kal1.1

Gene

anos1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I17.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kal1.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:anos1aImported
Synonyms:kal1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-000201-9 anos1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 167WAPInterPro annotationAdd BLAST50
Domaini173 – 278Fibronectin type-IIIInterPro annotationAdd BLAST106
Domaini283 – 387Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini402 – 498Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini524 – 631Fibronectin type-IIIInterPro annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 287DisorderedSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4802 Eukaryota
ENOG4111T0F LUCA

KEGG Orthology (KO)

More...
KOi
K23413

Database of Orthologous Groups

More...
OrthoDBi
979841at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9IAR4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits
4.10.75.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042447 Anosmin-1
IPR040957 Anosmin-1_Cys_box
IPR036645 Elafin-like_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR008197 WAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14131 PTHR14131, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17869 Cys_box, 1 hit
PF00041 fn3, 3 hits
PF00095 WAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00003 4DISULPHCORE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00217 WAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits
SSF57256 SSF57256, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 4 hits
PS51390 WAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9IAR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDGLTGLCI GIILLLNGGL VVMRRQDSSS ALGSIFRTRC AARCLSLHST
60 70 80 90 100
RIALSPRHFQ SNGSLGWCQS HKQCAKCLEP CKDSWELKDG PCRDLCEHAF
110 120 130 140 150
PKRHGECVTS CEFLRSVMVV KQGDCPPPER ASGFAAACVE GCEEDGECSG
160 170 180 190 200
QKKCCPNGCG HTCQSPKNLY RGAPLKPRKE LVFEELESGV LEVRWSSKFN
210 220 230 240 250
VSAEPVLNVL QRRWNYGIHP SEDGATEWQV VARTSGERVW LTDIRPGRWY
260 270 280 290 300
QFRVAAVNVH GTRGYTTPSR HFRSSKDPPP PPAPSDLHVS DMTFGADHSA
310 320 330 340 350
SVRLSWSISA DLDIPVNHYK LSWSSSDHNL PPKLKKRETV NGDSTYAELD
360 370 380 390 400
DLRENGSYTV ELQAVSYWGQ VPLKSSKAIL QFTTSQTQSD LEPTVSPVFI
410 420 430 440 450
KPQSDLLDVG TPFYQDGQLQ VRVYWKKKDP TVNRYRVQWA PEFCSHNGSR
460 470 480 490 500
TQGKLITQEN FASLPGLQFS CKYKVIIQPV GLKGRTQVES TTFYTPSCAT
510 520 530 540 550
IQSKSPKPIP CSSVPVVQPK VLVKAENLTA AFSVYLGNVT GLFSWVVAMP
560 570 580 590 600
QQPQQVTGYQ VTWAEVITES RRNNLPNSLI SQSQILPPER NILVVSGLQL
610 620 630 640 650
ASLYRLEVQV ITAAGQGPAT SRTFQTPTHS KPVLHYKPRI KKHHLRSVIE

RH
Length:652
Mass (Da):72,582
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07D6D12D35AA1160
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF163310 mRNA Translation: AAF25779.1

NCBI Reference Sequences

More...
RefSeqi
NP_571433.1, NM_131358.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:30630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163310 mRNA Translation: AAF25779.1
RefSeqiNP_571433.1, NM_131358.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI17.001

Genome annotation databases

GeneIDi30630
KEGGidre:30630

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30630
ZFINiZDB-GENE-000201-9 anos1a

Phylogenomic databases

eggNOGiKOG4802 Eukaryota
ENOG4111T0F LUCA
KOiK23413
OrthoDBi979841at2759
PhylomeDBiQ9IAR4

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR042447 Anosmin-1
IPR040957 Anosmin-1_Cys_box
IPR036645 Elafin-like_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR008197 WAP_dom
PANTHERiPTHR14131 PTHR14131, 1 hit
PfamiView protein in Pfam
PF17869 Cys_box, 1 hit
PF00041 fn3, 3 hits
PF00095 WAP, 1 hit
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00217 WAP, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS51390 WAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9IAR4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9IAR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: December 11, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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