Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apoptosis-associated speck-like protein containing a CARD

Gene

pycard

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa-dependent apoptosis. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates a caspase leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-associated speck-like protein containing a CARD
Alternative name(s):
PYD and CARD domain-containing protein
Gene namesi
Name:pycard
Synonyms:asc, asc1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-000511-2 pycard

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646911 – 203Apoptosis-associated speck-like protein containing a CARDAdd BLAST203

Interactioni

Subunit structurei

Self-associates (Probable). Interacts (via pyrin domain) with caspa (via pyrin domain) (PubMed:12464617).Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9I9N6, 1 interactor

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9I9N6
SMRiQ9I9N6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91PyrinPROSITE-ProRule annotationAdd BLAST91
Domaini112 – 203CARDPROSITE-ProRule annotationAdd BLAST92

Domaini

The pyrin domain mediates homotypic interactions with pyrin domain of other proteins.By similarity

Phylogenomic databases

HOGENOMiHOG000010310
HOVERGENiHBG108341
InParanoidiQ9I9N6
PhylomeDBiQ9I9N6

Family and domain databases

CDDicd08330 CARD_ASC_NALP1, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50824 DAPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9I9N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESFKEHLQ EAFEDLGADN LRKFKSKLGD RRQEPRVTKS AIEKLKDEID
60 70 80 90 100
LADLMVGVFT SKDAVSVTVE ILRAIKCNAV ADDLLRNTGQ SESKGALSDE
110 120 130 140 150
SKCASSKAVS KVAFSKVNFI DEHWKELIDR VNNVDPILDI LRQKKVITNE
160 170 180 190 200
DYCTIRNKET PQKKMRELLT GPITCAGNKG KEVLYDALRE SNKFLMDDLE

DAE
Length:203
Mass (Da):22,867
Last modified:October 1, 2000 - v1
Checksum:iEF457179EB7A78A7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8E7Q7A8E7Q7_DANRE
Apoptosis-associated speck-like pro...
pycard
203Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231013 mRNA Translation: AAF66956.1
UniGeneiDr.8329

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231013 mRNA Translation: AAF66956.1
UniGeneiDr.8329

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GPPX-ray2.00A/B3-88[»]
5GPQX-ray2.10A119-201[»]
ProteinModelPortaliQ9I9N6
SMRiQ9I9N6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9I9N6, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-000511-2 pycard

Phylogenomic databases

HOGENOMiHOG000010310
HOVERGENiHBG108341
InParanoidiQ9I9N6
PhylomeDBiQ9I9N6

Miscellaneous databases

PROiPR:Q9I9N6

Family and domain databases

CDDicd08330 CARD_ASC_NALP1, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50824 DAPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASC_DANRE
AccessioniPrimary (citable) accession number: Q9I9N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again