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Protein
Submitted name:

Prion protein

Gene

PrP

Organism
Columba rupestris
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrionImported
LigandCopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prion proteinImported
Gene namesi
Name:PrPImported
OrganismiColumba rupestrisImported
Taxonomic identifieri126356 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500432717025 – 266Sequence analysisAdd BLAST242

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9I9F3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 135Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16
Domaini217 – 235Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the prion family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG008260

Family and domain databases

Gene3Di1.10.790.10, 1 hit
InterProiView protein in InterPro
IPR000817 Prion
IPR036924 Prion/Doppel_b-ribbon_dom_sf
IPR022416 Prion/Doppel_prot_b-ribbon_dom
IPR025860 Prion_N_dom
PANTHERiPTHR10502:SF134 PTHR10502:SF134, 1 hit
PfamiView protein in Pfam
PF00377 Prion, 1 hit
PF11587 Prion_bPrPp, 1 hit
SMARTiView protein in SMART
SM00157 PRP, 1 hit
SUPFAMiSSF54098 SSF54098, 1 hit
PROSITEiView protein in PROSITE
PS00291 PRION_1, 1 hit
PS00706 PRION_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I9F3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLLTTCCL LALLLAACTD VALSKKGKGK PSGGGWGAGS HRQPNYPRQP
60 70 80 90 100
GYPHNPGYPH NPGYPHNPGY PHNPGYPQNP GYPHNPGYPG WGQGYNPSSG
110 120 130 140 150
GSYHNQKPWK PPKTNFKHVA GAAAAGAVVG GLGGYAMGRV MSGMSYRFDS
160 170 180 190 200
PDEYRWWNEN SARYPNRVYY RDYSSPVSQD VFVADCFNIT VTEYSIGPAA
210 220 230 240 250
RKNTSEAVPA ANQTDVEMEN KVVTKVIREM CVQQYREYRL ASGIQLHPAD
260
TWLAVLLLLT TLFAMH
Length:266
Mass (Da):29,206
Last modified:October 1, 2000 - v1
Checksum:iED886B9271B5305E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF256081 Genomic DNA Translation: AAF73436.1

Similar proteinsi

Entry informationi

Entry nameiQ9I9F3_9COLU
AccessioniPrimary (citable) accession number: Q9I9F3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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