Bloom syndrome protein homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB
• ATP-dependent 3'-5' DNA helicase activity Source: GO_Central
• ATP-dependent DNA helicase activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• DNA-dependent ATPase activity Source: UniProtKB
• forked DNA-dependent helicase activity Source: UniProtKB
• four-way junction DNA binding Source: UniProtKB
• four-way junction helicase activity Source: UniProtKB
• protein homodimerization activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• single-stranded DNA binding Source: UniProtKB
• zinc ion binding Source: UniProtKB

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• DNA double-strand break processing Source: UniProtKB
• DNA duplex unwinding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• DNA replication Source: UniProtKB-KW
• double-strand break repair via homologous recombination Source: GO_Central
• protein complex oligomerization Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• protein homooligomerization Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481
• regulation of DNA-dependent DNA replication Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein homodimerization activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 28228481

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEEARAATNG GSGESQKLSN GEKSSQLEPG DVGNELLADI ELEEDDYLDV 
        60         70         80         90        100
VPPSPEEELP SFSPSVRNVS NIFKESPTDG RSAVHGTESE PELMAPKQPA 
       110        120        130        140        150
AEQDSSAEHA DKGLHLEQQL YSVMEDICKL VDAIPLHELT SISCAKELLQ 
       160        170        180        190        200
QRELRRKLLA DSGALNTNSV NGPRNWKACV QQDPSSRPGT PLCSGPGRGV 
       210        220        230        240        250
SSVGSTPKST NLPSVLSRTV NSSSFSTIRN QTLDKLDTSY SSKETDQEVI 
       260        270        280        290        300
CLEPAALPSP KVNGKGSTSL SRPSEASFNG SWCEKPTGRD SGNWRVPERP 
       310        320        330        340        350
TASTALKAQH TAPAGNPASG CWDVNDTDFD LDHFDIDDFD EGWEEAVAPE 
       360        370        380        390        400
AAPEAPPAPQ WQPLREGSAS LRCRLLAAAA GSAPGPHPTA PKSGCGISAK 
       410        420        430        440        450
SSSEPLVHNP AHERFRGMKF SHSEEMLKIF HRKFGLHSFR TNQLEAINAA 
       460        470        480        490        500
LLGEDCFILM PTGGGKSLCY QLPACVSAGV TVVISPLRSL IIDQVQKLKT 
       510        520        530        540        550
LDIASTYLTG DITDADASKT YMQLSKKDPI IKLLYVTPEK VCASNRLLSA 
       560        570        580        590        600
LENLYNRKLL ARFVIDEAHC VSQWGHDFRK DYKRLNMLRK KFHSVPMMAL 
       610        620        630        640        650
TATANPRVQK DIQNQLEMLK PQVFTMSFNR HNLKYDVLPK KPKKVAMDCL 
       660        670        680        690        700
EWIKKYHPHD SGIIYCLSRH ECDTTAAILQ KEGLAALAYH AGLTDSNRDL 
       710        720        730        740        750
VQKKWVNQEG CQVICATIAF GMGIDKPDVR YVIHASLPKS IEGYYQESGR 
       760        770        780        790        800
AGRDGEMSHC LLFYSYSDVT RLRRLILMEK DGNSHTRQTH FNNLYSMVHY 
       810        820        830        840        850
CENVVDCRRI QLLAYFGETD FNPNFCKDHP EVICDNCSRK KDYKSRNVTD 
       860        870        880        890        900
EVKSIIRFVQ QHCGQVGGIN GNRNTGSGRY TLNMMVDIFL GAKSAKIQSG 
       910        920        930        940        950
IFGKGAAYSR HNVERLFRKL VLDKILDEDL YITANDQAVA YVVLGEKAQA 
       960        970        980        990       1000
VLNGLLQVEF HETENASAIR KQRASVTKMS QREEMVKKCL GELTDTCKTL 
      1010       1020       1030       1040       1050
GKIFDVHYFN IFSTSTLKKI AETLSSDAEV LLQIDGVTED KLEKYGAEII 
      1060       1070       1080       1090       1100
KVMDKYSEWT TPEDAACQSV DTAPGSAGTP GSEEEAADDV VTSSYFGGNA 
      1110       1120       1130       1140       1150
NQRRKRKRLP NSGESKRKKT SSGGSQQFYS KGARYRRARR APGSRAAAPA 
      1160       1170       1180 
QSSALRGAGA RLGIMAPPKP SSRHFLQPSY AVL                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families