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UniProtKB - Q9I8L7 (Q9I8L7_DANRE)
Protein
Submitted name:
Homeobox protein
Gene
nkx2.4b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 147 – 206 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: GO_Central
- hypothalamus development Source: ZFIN
- regulation of transcription by RNA polymerase II Source: GO_Central
- thyroid gland development Source: ZFIN
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeobox proteinImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-000830-1, nkx2.4b |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 205 | HomeoboxInterPro annotationAdd BLAST | 61 |
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | GYCNGTI |
OrthoDBi | 1348801at2759 |
PhylomeDBi | Q9I8L7 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9I8L7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSPKHSTP FSVSDILSPI EETFKKFAAM ESSASLASPL YRQSQVSQAN
60 70 80 90 100
LQQHSMSHNA YHMPHSQFSH STMGGYCNGT IGAMGDLPSY QESMRNGATA
110 120 130 140 150
TAWYGSNPEP RYPTISRFMG PSAGMNMGTL PGMDASKSMV TLHAAPRRKR
160 170 180 190 200
RVLFSQAQVY ELERRFKQQK YLSAPEREHL ASMIHLTPTQ VKIWFQNHRY
210 220 230 240 250
KMKRQAKDKA SQQQDSGNMC AQQSPRRVAL PVLVKDGKPC QNGSGTPTPI
260 270 280 290 300
HQQVQSVLGS ETLASAEDLE EMSPSPPLMG GLSQTDAALI EYTSSMVSSN
LLYGRTW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF253054 mRNA Translation: AAF78912.1 |
RefSeqi | NP_571664.1, NM_131589.1 |
Genome annotation databases
GeneIDi | 58112 |
KEGGi | dre:58112 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF253054 mRNA Translation: AAF78912.1 |
RefSeqi | NP_571664.1, NM_131589.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 58112 |
KEGGi | dre:58112 |
Organism-specific databases
CTDi | 58112 |
ZFINi | ZDB-GENE-000830-1, nkx2.4b |
Phylogenomic databases
OMAi | GYCNGTI |
OrthoDBi | 1348801at2759 |
PhylomeDBi | Q9I8L7 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9I8L7_DANRE | |
Accessioni | Q9I8L7Primary (citable) accession number: Q9I8L7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2000 |
Last sequence update: | October 1, 2000 | |
Last modified: | June 2, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |