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Entry version 98 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Period3 circadian clock protein

Gene

per3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythmsARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Period3 circadian clock proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:per3Imported
Synonyms:Per3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-000804-1, per3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9I8L4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini388 – 434PASInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 176DisorderedSequence analysisAdd BLAST176
Regioni663 – 686DisorderedSequence analysisAdd BLAST24
Regioni745 – 784DisorderedSequence analysisAdd BLAST40
Regioni824 – 900DisorderedSequence analysisAdd BLAST77
Regioni1041 – 1162DisorderedSequence analysisAdd BLAST122
Regioni1251 – 1281DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 44Polar residuesSequence analysisAdd BLAST29
Compositional biasi46 – 74Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi88 – 107Basic residuesSequence analysisAdd BLAST20
Compositional biasi108 – 140Polar residuesSequence analysisAdd BLAST33
Compositional biasi141 – 176Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi832 – 856Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi876 – 891Polar residuesSequence analysisAdd BLAST16
Compositional biasi1051 – 1072Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1073 – 1140Polar residuesSequence analysisAdd BLAST68
Compositional biasi1141 – 1162Basic and acidic residuesSequence analysisAdd BLAST22

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAQLPFW

Database of Orthologous Groups

More...
OrthoDBi
331262at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9I8L4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013655, PAS_fold_3
IPR015524, Per_circ_prot_3
IPR022728, Period_circadian-like_C

The PANTHER Classification System

More...
PANTHERi
PTHR11269:SF13, PTHR11269:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08447, PAS_3, 1 hit
PF12114, Period_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55785, SSF55785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9I8L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGGDGFPDG EQENSSPGPD IHTGQTDQTS SGQDPGTSGN ISASGEEEEA
60 70 80 90 100
EERIGRRSSG CEESGGEQTH EDVDMNSTHT SSSGNDSIHH RHHHHHRHHH
110 120 130 140 150
HHHHHSSSNC SPGSTTGSGS TKSSKSATGS SSSSFHSTHH TECGEQTETG
160 170 180 190 200
REHTHREMMH TVQEMKKRLP SEKRSRSKAS TVEALHYALN CVKQVQANSE
210 220 230 240 250
YYNLLMSSGL DERRDATVCT LEELEGFTSE HTLKNTDSFV VVFSLASGKV
260 270 280 290 300
VYASEQASSV LHCKRKFLES AKFVEMLYHQ DVNVFYSHTA QPRLPSWNLG
310 320 330 340 350
TDSAAVLFEC AQVKSFFCRI RGGKDRDGDM RYSPFRITPY LLKVQGSSGE
360 370 380 390 400
EEPCCLALAE RIISGYEAPR IPMDKRIFST THSPGCVFLE VDDRAVPLLG
410 420 430 440 450
YLPQDLIGTS VLTCLHPDDR LLMLAMHRKI VKYAGQPPFE HSPIRFRCQN
460 470 480 490 500
GDYVTLDSSW SSFINPWSRK VAFIIGRHKV RTGPLNEDVF AARSKADQPV
510 520 530 540 550
MCEDVKELQA MIHKLFLQPV HNNGSSGYGS LGSNGSHEHY ISVASSSDSN
560 570 580 590 600
GNLWEDSHRE TMTLQQFCAD VNKVKNWGQQ AYLESRKKLT ALGPATAVAG
610 620 630 640 650
AGVHASSSHD LGIRDHLKQS LQKARKQPHI PSYQQINCVD SIIRYLESCA
660 670 680 690 700
TSALKRKCES LSITTSSSSS TSEEDKPTAA AHENTDEAAL DAARALDSQV
710 720 730 740 750
SAGSATTAAV VGAPLTDITI STEAMSVVSV TSQCSYSSTI VHVPQPESEV
760 770 780 790 800
TALEDAPMGS EPADSAPAPA SPAHDSGSAS TSQEELLVLG LTKEVLSAHT
810 820 830 840 850
QKEEQQFVDR FRHRIVQSPY SSYLQQDNSS NAHSHHRGDV VRQPNKHKRP
860 870 880 890 900
KPEDSSDSYE CSQPGNYWSL PGPTAAPHSS WPSSESSQPP PSNIGFVPPM
910 920 930 940 950
AVPMQTPPYF NIIGADQQPV MLQPDPGVQN LQPMTPMMVV LLPSFPMYPP
960 970 980 990 1000
NNGMYFPMAA PGVVPYNIGG FVPPGTPMPA EAPLQGHNLE SAGVGVPAEP
1010 1020 1030 1040 1050
DSIPEPWFGE DLDAAQPTAL FSSSRSSSPI QLNLLQEELT KPSEAQTSTN
1060 1070 1080 1090 1100
ADSLHEHHTK TDDARSECGH QDAHSSSSEM LDQLLQEDAR SGTGSNASGS
1110 1120 1130 1140 1150
GSGESGGSLG SGSGLGSNGT STSHTGSSNS SKYFASNDSS DTSRKARKSA
1160 1170 1180 1190 1200
EAQERERSGF KKHVDDPLWS MIKQTPEPVM LTYQISSRDQ AQVLQEDREK
1210 1220 1230 1240 1250
LILMQPMQPW FTSDQKKELA EVHPWIQQNT VPQEINTQGC VSCNTIEPNE
1260 1270 1280
KLNLQTDSPN PPDISCPQDC PPQENRPDTD T
Length:1,281
Mass (Da):139,421
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E50AFC8FECDAF91
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF254792 mRNA Translation: AAF87986.1

NCBI Reference Sequences

More...
RefSeqi
NP_571659.1, NM_131584.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58107

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:58107

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254792 mRNA Translation: AAF87986.1
RefSeqiNP_571659.1, NM_131584.1

3D structure databases

SMRiQ9I8L4
ModBaseiSearch...

Genome annotation databases

GeneIDi58107
KEGGidre:58107

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8863
ZFINiZDB-GENE-000804-1, per3

Phylogenomic databases

OMAiHAQLPFW
OrthoDBi331262at2759
PhylomeDBiQ9I8L4

Family and domain databases

CDDicd00130, PAS, 1 hit
InterProiView protein in InterPro
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013655, PAS_fold_3
IPR015524, Per_circ_prot_3
IPR022728, Period_circadian-like_C
PANTHERiPTHR11269:SF13, PTHR11269:SF13, 1 hit
PfamiView protein in Pfam
PF08447, PAS_3, 1 hit
PF12114, Period_C, 1 hit
SMARTiView protein in SMART
SM00091, PAS, 2 hits
SUPFAMiSSF55785, SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS50112, PAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9I8L4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I8L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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