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Protein
Submitted name:

Caspase-8

Gene

casp8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: InterPro
  • induction by virus of host apoptotic process Source: ZFIN
  • positive regulation of apoptotic process Source: ZFIN
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-8Imported
Gene namesi
Name:casp8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-000713-1 casp8

Structurei

3D structure databases

ProteinModelPortaliQ9I8J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77DEDInterPro annotationAdd BLAST77
Domaini98 – 173DEDInterPro annotationAdd BLAST76
Domaini236 – 359CASPASE_P20InterPro annotationAdd BLAST124
Domaini388 – 473CASPASE_P10InterPro annotationAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 92Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
HOVERGENiHBG050803
PhylomeDBiQ9I8J3

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR033170 Caspase-8
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454:SF162 PTHR10454:SF162, 1 hit
PfamiView protein in Pfam
PF01335 DED, 2 hits
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SM00031 DED, 2 hits
SUPFAMiSSF47986 SSF47986, 2 hits
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit
PS50168 DED, 2 hits

Sequencei

Sequence statusi: Complete.

Q9I8J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQIFHEID ENLTSGDVDQ LKFLCLDFIP KRRLESVTDA KDLILRLDEQ
60 70 80 90 100
GLLEDELLFP ELLIAIGRID LLEILKKSKE EVERNLLRCD NSRKGVSAYR
110 120 130 140 150
KMLLKISEDM TEENFRAAKF LLDLPRAKLG RSTSFLDALI EMEKQQRLGP
160 170 180 190 200
DNLDELYRIL EKCDKQLAVM IERFRNQSHR DQEQGGRLPL EEVFLNNPVS
210 220 230 240 250
DTMERERRRN SSAGAITTDA ETPLNPNEYY ILTQRPLGYC LIINNYNFLE
260 270 280 290 300
STNLLKRTGT DMDKDRLAKL FSRMHFQIEV RNDLEAWAIK DEIKQFANRN
310 320 330 340 350
HASMGAFVCC ILSHGEKGTV LGTDGKPVEI REVTLPFAGC RTLASKPKLF
360 370 380 390 400
FIQACQGDEN QAGVWTSDGR EDAPEEDEEY EEDAGIIVLR KIPIEADFLI
410 420 430 440 450
GMATVEHYLS YRHTKKGSIF IQELCKKMEE LCPKKEDMLS ILTKVNFEVS
460 470
KRILKGYKQM PEPRYTLTKK LVLPID
Length:476
Mass (Da):54,890
Last modified:October 1, 2000 - v1
Checksum:iFD9DFF4B3C3C1FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273220 mRNA Translation: AAF79207.1
UniGeneiDr.10334

Similar proteinsi

Entry informationi

Entry nameiQ9I8J3_DANRE
AccessioniPrimary (citable) accession number: Q9I8J3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: January 31, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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