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Protein

Ashwin

Gene

c2orf49

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May regulate cell survival and anterior-posterior patterning.

GO - Biological processi

  • anterior/posterior pattern specification Source: AgBase
  • convergent extension involved in gastrulation Source: AgBase
  • embryonic morphogenesis Source: AgBase
  • regulation of apoptotic process Source: AgBase
  • Spemann organizer formation at the dorsal lip of the blastopore Source: AgBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ashwin
Gene namesi
Name:c2orf49
Synonyms:asw, asw-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-939826 c2orf49

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688641 – 226AshwinAdd BLAST226

Proteomic databases

MaxQBiQ9I8G4

Expressioni

Tissue specificityi

Expressed in the neural plate and later in the embryonic brain, eyes, and spinal cord.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Up-regulated in the neural ectoderm after the mid-gastrula stage.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi98919, 1 interactor
IntActiQ9I8G4, 1 interactor

Family & Domainsi

Sequence similaritiesi

Belongs to the ashwin family.Curated

Phylogenomic databases

HOVERGENiHBG080774
KOiK15432

Family and domain databases

InterProiView protein in InterPro
IPR024887 Ashwin
PANTHERiPTHR28359 PTHR28359, 1 hit
PfamiView protein in Pfam
PF15323 Ashwin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I8G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAVGSAGI LVKESALLLH PELLSRDFLL LSLERRNIPV EDALNNKEKL
60 70 80 90 100
TEIFVQHAMP LPQRDLPRNR WGRMMESKRG ENKIATVLKS AGTEGGRKRP
110 120 130 140 150
PIVFDGCSTS TTIKVKRTEN GDASQRLNPS PKESTNSTQN SNPAPRLGSP
160 170 180 190 200
TPNKEAKVAT TGNHGQLDSL PVTDSALVSP KSAKLQQSMI INAVKLKRNA
210 220
PKEEFDVAND TKPTEAKKKI QHVTWP
Length:226
Mass (Da):24,783
Last modified:June 1, 2002 - v2
Checksum:i8EA60E5D5B1A97C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45N → I in AAI29762 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281253 mRNA Translation: AAF82384.2
BC129761 mRNA Translation: AAI29762.1
BC167560 mRNA Translation: AAI67560.1
RefSeqiNP_001080993.1, NM_001087524.1
UniGeneiXl.659

Genome annotation databases

GeneIDi394317
KEGGixla:394317

Similar proteinsi

Entry informationi

Entry nameiASHWN_XENLA
AccessioniPrimary (citable) accession number: Q9I8G4
Secondary accession number(s): A2VDC9, B3DLS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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