Interleukin-18

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-18 receptor binding Source: Ensembl

GO - Biological processⁱ

• activation of protein kinase B activity Source: Ensembl
• angiogenesis Source: Ensembl
• CD4-positive, alpha-beta T cell activation Source: AgBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species."
    Gobel T.W., Schneider K., Schaerer B., Mejri I., Puehler F., Weigend S., Staeheli P., Kaspers B.
    J Immunol 171:1809-1815(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: Ensembl
• inflammatory response Source: UniProtKB-UniRule
• interleukin-18-mediated signaling pathway Source: Ensembl
• lipopolysaccharide-mediated signaling pathway Source: Ensembl
• MAPK cascade Source: Ensembl
• positive regulation of activated T cell proliferation Source: Ensembl
• positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
• positive regulation of interferon-gamma production Source: AgBaseInferred from direct assayⁱ
  • "IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species."
    Gobel T.W., Schneider K., Schaerer B., Mejri I., Puehler F., Weigend S., Staeheli P., Kaspers B.
    J Immunol 171:1809-1815(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-17 production Source: Ensembl
• positive regulation of lymphocyte proliferation Source: AgBaseInferred from direct assayⁱ
  • "IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species."
    Gobel T.W., Schneider K., Schaerer B., Mejri I., Puehler F., Weigend S., Staeheli P., Kaspers B.
    J Immunol 171:1809-1815(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of natural killer cell proliferation Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of NK T cell proliferation Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• positive regulation of T-helper 1 cell cytokine production Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
• T-helper 1 type immune response Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• interleukin-18 receptor binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSCEEIAVCA VRLRENLCLY FEDDELECDA FCKDKTIKRF FRNVNSQLLV 
        60         70         80         90        100
VRPDLNVAAF EDVTDQEVKS GSGMYFDIHC YKTTAPSAGM PVAFSVQVED 
       110        120        130        140        150
KSYYMCCEKE HGKMVVRFRE GEVPKDIPGE SNIIFFKKTF TSCSSKAFKF 
       160        170        180        190 
EYSLEQGMFL AFEEEDSLRK LILKKLPRED EVDETTKFVT SHNERHNL   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ