UniProtKB - Q9I7T7 (LAR4_DROME)
Protein
La-related protein Larp4B
Gene
Larp4B
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probable RNA binding protein. Negatively regulates myc at the protein level, via an unknown mechanism, and may therefore have a role in growth. Has no effect on myc mRNA levels.1 Publication
GO - Molecular functioni
- mRNA 3'-UTR binding Source: FlyBase
GO - Biological processi
- negative regulation of cell growth Source: FlyBase
- negative regulation of translation Source: FlyBase
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein Larp4B1 PublicationAlternative name(s): La ribonucleoprotein domain family member Larp4BCurated |
Gene namesi | ORF Names:CG115051 Publication |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0035424, Larp4B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000372865 | 1 – 1531 | La-related protein Larp4BAdd BLAST | 1531 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1123 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1370 | Phosphoserine2 Publications | 1 | |
Modified residuei | 1413 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9I7T7 |
PRIDEi | Q9I7T7 |
PTM databases
iPTMneti | Q9I7T7 |
Expressioni
Developmental stagei
Expressed throughout development and in adults. Ubiquitously expressed in the central nervous system and imaginal disks.1 Publication
Gene expression databases
Bgeei | FBgn0035424, Expressed in adult organism and 26 other tissues |
Genevisiblei | Q9I7T7, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 63895, 62 interactors |
IntActi | Q9I7T7, 2 interactors |
STRINGi | 7227.FBpp0072910 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 262 – 351 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 348 – 423 | RRMPROSITE-ProRule annotationAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 96 | Ala-richPROSITE-ProRule annotationAdd BLAST | 66 | |
Compositional biasi | 97 – 157 | Gln-richPROSITE-ProRule annotationAdd BLAST | 61 | |
Compositional biasi | 629 – 1297 | Gln-richPROSITE-ProRule annotationAdd BLAST | 669 | |
Compositional biasi | 925 – 974 | His-richPROSITE-ProRule annotationAdd BLAST | 50 | |
Compositional biasi | 958 – 1026 | Gly-richPROSITE-ProRule annotationAdd BLAST | 69 |
Domaini
The HTH La-type RNA-binding and RRM domains are required for its function in negatively regulating organ and cell size.1 Publication
Phylogenomic databases
eggNOGi | KOG2591, Eukaryota |
GeneTreei | ENSGT00940000172042 |
HOGENOMi | CLU_247266_0_0_1 |
InParanoidi | Q9I7T7 |
OMAi | KPPRNTQ |
OrthoDBi | 771508at2759 |
PhylomeDBi | Q9I7T7 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR035979, RBD_domain_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform B (identifier: Q9I7T7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEYFLGGYVY MNGDALKIQP PVYTNVPVET AMLATNLFGA TTQIAASPAA
60 70 80 90 100
AAAAHIPLIT AAAAAAAAAG APAVAPPVAV APVATASAAQ AAVVPAQQQQ
110 120 130 140 150
QAHPHQAQIL AHTHVAHQQQ QQQQQQTIQQ HLHQQQQQQS PHPAQHLTYG
160 170 180 190 200
HQPALSQATA GGSGTISGGA VGPSGVVVEG QDTNEYAIMN GALGQTQDGT
210 220 230 240 250
VVCYTTDALN NTNLVALDPQ PHQIVVPVQV PVQVPVPVQL PANGSADPQQ
260 270 280 290 300
GSHNAAGGEE PNIPLDKLKQ MLATQLEYYF SRENLANDTY LLSQMDSDQY
310 320 330 340 350
VPIYTVARFN LVRKLTNDIN LITEVLRESP NVQVDDKGLR VRPNRKRCII
360 370 380 390 400
ILREISNNTP LDDVKALFSN ESCPRPISCE FAANNSWYIT FESDEDAQKA
410 420 430 440 450
YKYLREEVKE FQGKPIMARI KPKSFINRIQ AVPKNGYRLT SPPTANVFDP
460 470 480 490 500
AGAGGATVSY AAAQQPRYLY TNGAAIAAPA SVQYSNPVLI PIPQNQFYPG
510 520 530 540 550
LVAGPWPPGT VAATTAHGQN FYELGGNIFT TNPLPPQPVT AGFAQAPPPT
560 570 580 590 600
SQAMVTPKPQ GGGRYNNNHR GNPNNVGGAN SGPRAESRSK PPRSTPSASH
610 620 630 640 650
IQGGNIMPIQ ITAPIPGGMV SVVPTNIVQD PLQPAPLQQQ PQQVIQQIQQ
660 670 680 690 700
QPSSSAQQQQ AATVQMNNTT RHYPIKSNWK GGMQKNLDKS YSGGVATHHH
710 720 730 740 750
YTTQVQALPA HSHHLQAQQQ LQGQTQQQHY QLASSSAASA PQVTYVTTAP
760 770 780 790 800
APQQPGQHQH HLVVQQTQPQ QQQQQQQVVL QQQQVQVQEL QEAGDGVEHS
810 820 830 840 850
SHAMQQVNRS SNMSASSSSS LATSMSKEPL QWQNRPRRRR RDEEGGINYS
860 870 880 890 900
PGGRVGLYGS SPSNPHPQQH LMSSSTGSNV QSAGGTDGGG ASHRGGERQS
910 920 930 940 950
HYNTIHDVPP PQHRGNYKGN NYNPHYHAQH SSMASGSHHH HHHNALSSQQ
960 970 980 990 1000
QQHHLTTGTG QQGSGHHYHH HHHHNSIGSN VGNSGGLGVS SGGSGGGGSG
1010 1020 1030 1040 1050
GGSGSNSLSG GSNERGIHHS SLGYQGHQHQ HQQQQQQQQQ QQQQQPAAPV
1060 1070 1080 1090 1100
QPPQFDLEDA AFPPLPATSA TAPHTPQATG GASLHNSTTS SSSSTGLGQK
1110 1120 1130 1140 1150
QTLHQQQQQA PQQHQVLSSS VESAGGDEQR SSNQQGIETS NIHLANSSTA
1160 1170 1180 1190 1200
NNWVENRLSD VVRTGGGGGG GGKGKARKDN RHPQGQNQPH MAPNYQQHQP
1210 1220 1230 1240 1250
RNPPVSPTPA LGAEYGIQIQ EGNNTKNVTK QSSSNNNSIH VIKCQTPNIN
1260 1270 1280 1290 1300
ASSKEEAAGA QQQQQQQLDK SNKTEDEMHP KQPSQQRLVE GYVQQQQLPL
1310 1320 1330 1340 1350
LAAHNEYSAA LAAGAGACSV VEGGLTTSLA ECSLGQHKKP PSVAALHAKK
1360 1370 1380 1390 1400
DANLLEKGAS KHKSVATSTS TENLSAAATA SKLSYAQVAQ HHKAAASSDS
1410 1420 1430 1440 1450
KETGSGGSTG TLSPTGSHKM DLVFGDPAVV VAAVEKSGLA TVSTEKRVAG
1460 1470 1480 1490 1500
GASPAALIGK PAGGLPATNT TQGSSAVVVS AKEKDNRPNA SVRPLSKEKQ
1510 1520 1530
QQHYGSATEH NTNANIGLGA SGNRKSRANN S
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | Q → QQQH in AAQ22587 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1439 | L → I in AAQ22587 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037217 | 1 – 10 | Missing in isoform A. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF47745.1 AE014296 Genomic DNA Translation: AAG22237.2 AE014296 Genomic DNA Translation: AAS64955.2 BT010118 mRNA Translation: AAQ22587.1 Sequence problems. BT150483 mRNA Translation: AKR06211.1 |
RefSeqi | NP_647793.1, NM_139536.4 [Q9I7T7-1] NP_728843.1, NM_168007.2 [Q9I7T7-2] NP_995985.2, NM_206263.4 [Q9I7T7-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0073045; FBpp0072909; FBgn0035424 [Q9I7T7-2] FBtr0073046; FBpp0072910; FBgn0035424 [Q9I7T7-1] FBtr0308061; FBpp0300406; FBgn0035424 [Q9I7T7-2] |
GeneIDi | 38399 |
KEGGi | dme:Dmel_CG11505 |
UCSCi | CG11505-RA, d. melanogaster CG11505-RB, d. melanogaster [Q9I7T7-1] CG11505-RC, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF47745.1 AE014296 Genomic DNA Translation: AAG22237.2 AE014296 Genomic DNA Translation: AAS64955.2 BT010118 mRNA Translation: AAQ22587.1 Sequence problems. BT150483 mRNA Translation: AKR06211.1 |
RefSeqi | NP_647793.1, NM_139536.4 [Q9I7T7-1] NP_728843.1, NM_168007.2 [Q9I7T7-2] NP_995985.2, NM_206263.4 [Q9I7T7-2] |
3D structure databases
SMRi | Q9I7T7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 63895, 62 interactors |
IntActi | Q9I7T7, 2 interactors |
STRINGi | 7227.FBpp0072910 |
PTM databases
iPTMneti | Q9I7T7 |
Proteomic databases
PaxDbi | Q9I7T7 |
PRIDEi | Q9I7T7 |
Genome annotation databases
EnsemblMetazoai | FBtr0073045; FBpp0072909; FBgn0035424 [Q9I7T7-2] FBtr0073046; FBpp0072910; FBgn0035424 [Q9I7T7-1] FBtr0308061; FBpp0300406; FBgn0035424 [Q9I7T7-2] |
GeneIDi | 38399 |
KEGGi | dme:Dmel_CG11505 |
UCSCi | CG11505-RA, d. melanogaster CG11505-RB, d. melanogaster [Q9I7T7-1] CG11505-RC, d. melanogaster |
Organism-specific databases
CTDi | 23185 |
FlyBasei | FBgn0035424, Larp4B |
Phylogenomic databases
eggNOGi | KOG2591, Eukaryota |
GeneTreei | ENSGT00940000172042 |
HOGENOMi | CLU_247266_0_0_1 |
InParanoidi | Q9I7T7 |
OMAi | KPPRNTQ |
OrthoDBi | 771508at2759 |
PhylomeDBi | Q9I7T7 |
Miscellaneous databases
BioGRID-ORCSi | 38399, 1 hit in 3 CRISPR screens |
ChiTaRSi | CG11505, fly |
GenomeRNAii | 38399 |
PROi | PR:Q9I7T7 |
Gene expression databases
Bgeei | FBgn0035424, Expressed in adult organism and 26 other tissues |
Genevisiblei | Q9I7T7, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR035979, RBD_domain_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAR4_DROME | |
Accessioni | Q9I7T7Primary (citable) accession number: Q9I7T7 Secondary accession number(s): A0A0H4YFU3 Q9VZS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase