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Entry version 142 (11 Dec 2019)
Sequence version 2 (03 Mar 2009)
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Protein

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Gene

Pde9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP.By similarity

Caution

No activity observed following immunoprecipitation from adult head (PubMed:15673286). However, it is likely that the protein has phosphodiesterase activity based on the conservation of the active site as well as nucleotide-binding and metal-binding sites.Curated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic GMP degradation

This protein is involved in step 1 of the subpathway that synthesizes GMP from 3',5'-cyclic GMP.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Pde9)
This subpathway is part of the pathway 3',5'-cyclic GMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from 3',5'-cyclic GMP, the pathway 3',5'-cyclic GMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei740Proton donorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi744Zinc; via tele nitrogenBy similarity1
Metal bindingi780Zinc; via tele nitrogenBy similarity1
Metal bindingi781MagnesiumBy similarity1
Metal bindingi781ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei781cGMPBy similarity1
Metal bindingi890ZincBy similarity1
Binding sitei890cGMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi740 – 744cGMPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcGMP, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00763;UER00748

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9ACurated (EC:3.1.4.35By similarity)
Alternative name(s):
Phosphodiesterase 91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pde9Imported
ORF Names:CG42276Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0259171 Pde9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004388631 – 1526High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AAdd BLAST1526

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9I7S6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Malpighian tubules and adult fly head.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0259171 Expressed in 22 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9I7S6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9I7S6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305705

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9I7S6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 985PDEasePROSITE-ProRule annotationAdd BLAST322

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 38Ala-richPROSITE-ProRule annotationAdd BLAST20
Compositional biasi23 – 96Thr-richPROSITE-ProRule annotationAdd BLAST74
Compositional biasi155 – 174Gln-richPROSITE-ProRule annotationAdd BLAST20
Compositional biasi338 – 366Ser-richPROSITE-ProRule annotationAdd BLAST29
Compositional biasi411 – 430Asn-richPROSITE-ProRule annotationAdd BLAST20
Compositional biasi588 – 610Asn-richPROSITE-ProRule annotationAdd BLAST23
Compositional biasi1019 – 1063Gly-richPROSITE-ProRule annotationAdd BLAST45
Compositional biasi1314 – 1388Ser-richPROSITE-ProRule annotationAdd BLAST75
Compositional biasi1325 – 1442Gly-richPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3689 Eukaryota
ENOG410XRI7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165301

KEGG Orthology (KO)

More...
KOi
K13761

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRCHINS

Database of Orthologous Groups

More...
OrthoDBi
904682at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00387 PDIESTERASE1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471 HDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9I7S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYQDSGCSSS SSRRGSSSAA AATSTAATAA ETAAAAAATT TSSSDEETLE
60 70 80 90 100
TLTIITTTIT DSDIHATTTT TTVIASGTAT TAAAAATTAT LATLATLASN
110 120 130 140 150
SDIEDSSPVE SEDSEECEYI EIDCQTTAQE GTSPSGGSSS SGNAVLLQRS
160 170 180 190 200
SNNLQQQQQQ QQQQQQHLQL QLQQADERLL RKIGYIASRV RCLSKYYGDF
210 220 230 240 250
RLVNPYSARR QRRQLQEILL RHSIFDPGKE HQRAIVLAAA TAAIAGPLAA
260 270 280 290 300
IDCVCGSSSI SLEAVSSRSR SSELEDDHHE QDQVQEEQEQ EQHQGDTEDN
310 320 330 340 350
EEEQEHPSEK PERTDIEEEP PPAIAVTTTT TATVRRKSSS SSTISGTATV
360 370 380 390 400
SGSVSVSASA SQSFCSNNIN LLEELLIQFY EEQDHRSNLT VIRHHHHQQH
410 420 430 440 450
QQHQQQQRIT NNNNNNNNCN SIQNNNNMSN PAATAAATAT PSVEQPATSG
460 470 480 490 500
TTNIHLQPTS LPDGSDNPRR RRASDCSAVQ AALQNQLHCI TLKNNNCGKA
510 520 530 540 550
MPFHRGSCGA AGEHLLAANS IANRATIILS KSCSNVDGDA TATAATALSS
560 570 580 590 600
TVGGGIGGIG GSIKMRASAT DIETNALNGA RDAIVASNNG NNGNNGNNGN
610 620 630 640 650
NEYSILQLNN TIIQCHFNDD DFRALVKDLK RKVEYTERMN WLCLSKRPLG
660 670 680 690 700
PPHRKSSLPK HQEVKRRFLE ICDTTFSEEV RAALRLPAFD SYEWSDADVI
710 720 730 740 750
HLMQTMFVEL GFIEKFSIPV DTLREWLYEV YKHYNEVPFH NFRHCFCVAQ
760 770 780 790 800
MMYAITRQAN LLSRLGDLEC LILLVSCICH DLDHPGYNNI YQINARTELA
810 820 830 840 850
LRYNDISPLE NHHCSIAFRL LEHPECNIFK NFSRDTFNNI REGIIRCILA
860 870 880 890 900
TDMARHNEIL TQFMEITPIF DYSNRAHINL LCMILIKVAD ISNEARPMDV
910 920 930 940 950
AEPWLDRLLQ EFFAQSAAEK SEGLPVTPFM DPDKVSKPGS QVRFIGLVLL
960 970 980 990 1000
PLFEALGELV PELTELIIIP VRIALEYYRR LNDAQTKTRK SVADSNTSAT
1010 1020 1030 1040 1050
SDSNSGTIDS NAAMVSTPGG ASDKLSLDKG QGNSQGSGGG GGGGGGGGAG
1060 1070 1080 1090 1100
GGTGSGCGSN AAGSVSPQMP RSGSGISVKS RRSIPSQKSA SRTSVDEPGG
1110 1120 1130 1140 1150
MASELHDLPE GSESGDSETA TEVDVAEKTS KFKVDTEGSS NRSKSSHSTS
1160 1170 1180 1190 1200
RKSSREKRPS MIGELCSSGG GQRIRNSYGN IHGYHSNRCH FGNNRAVSLD
1210 1220 1230 1240 1250
QYSSAGNNRR LSDGLPQVIS DSNVFYGRHN RSSTETTVAV GNPQDTNANT
1260 1270 1280 1290 1300
NHPVGCQLKE LLARTEADSD GEGDGNGRED KKIPLVIPSM PQLATSSNGN
1310 1320 1330 1340 1350
ISPTLVVTEQ ILPSNGSTRS SASSGRGGSG VPGGSGGSGM PGPSAGSGSS
1360 1370 1380 1390 1400
WKSRLRQFSD YFSFSFDKSN KRFGSTRSSP CPGSNSSSGR TNNNANGLGE
1410 1420 1430 1440 1450
NQDGLGAGGG IKPGMCCTTI TNSSGSTVKG ETRGGTAGAG GGALTTMTTG
1460 1470 1480 1490 1500
NDAHQRHRAY SLDVPGMMRY SSNDSSRHPS NNTLQSAGGG AGLTTGLEVT
1510 1520
AQRVPPSLSV EMGLASGSSS EAGPKI
Length:1,526
Mass (Da):162,819
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3B5EA9223D6768B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VYJ0Q9VYJ0_DROME
Phosphodiesterase
Pde9 CG1627, CG32648, CG3754, CG3761, CG3765
1,623Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAG22348.2
AE014298 Genomic DNA Translation: AGB95337.1
AE014298 Genomic DNA Translation: AGB95338.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259495.1, NM_001272566.1
NP_001259496.1, NM_001272567.2
NP_572834.2, NM_132606.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0299635; FBpp0288910; FBgn0259171
FBtr0333524; FBpp0305704; FBgn0259171
FBtr0333525; FBpp0305705; FBgn0259171

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG42276

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAG22348.2
AE014298 Genomic DNA Translation: AGB95337.1
AE014298 Genomic DNA Translation: AGB95338.1
RefSeqiNP_001259495.1, NM_001272566.1
NP_001259496.1, NM_001272567.2
NP_572834.2, NM_132606.5

3D structure databases

SMRiQ9I7S6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9I7S6, 3 interactors
STRINGi7227.FBpp0305705

Proteomic databases

PRIDEiQ9I7S6

Genome annotation databases

EnsemblMetazoaiFBtr0299635; FBpp0288910; FBgn0259171
FBtr0333524; FBpp0305704; FBgn0259171
FBtr0333525; FBpp0305705; FBgn0259171
GeneIDi32233
KEGGidme:Dmel_CG42276

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32233
FlyBaseiFBgn0259171 Pde9

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00940000165301
KOiK13761
OMAiPRCHINS
OrthoDBi904682at2759

Enzyme and pathway databases

UniPathwayiUPA00763;UER00748

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32233

Protein Ontology

More...
PROi
PR:Q9I7S6

Gene expression databases

BgeeiFBgn0259171 Expressed in 22 organ(s), highest expression level in head
ExpressionAtlasiQ9I7S6 baseline and differential

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE9A_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I7S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: March 3, 2009
Last modified: December 11, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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