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Entry version 169 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

ATP-dependent DNA helicase II subunit 2

Gene

Ku80

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded DNA-dependent ATP-dependent helicase.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation, HelicaseUniRule annotationARBA annotation, Hydrolase
Biological processDNA damage, DNA recombinationUniRule annotationARBA annotation, DNA repairUniRule annotationARBA annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent DNA helicase II subunit 2UniRule annotation (EC:3.6.4.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ku80Imported
Synonyms:BG:DS09217.6Imported, Dmel\CG18801Imported, DmKu80Imported, KuImported, KU80Imported, ku80Imported
ORF Names:CG18801Imported, Dmel_CG18801Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0041627, Ku80

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0041627

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9I7M8

PRoteomics IDEntifications database

More...
PRIDEi
Q9I7M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041627, Expressed in testis and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9I7M8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9I7M8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9I7M8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9I7M8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini275 – 415KuInterPro annotationAdd BLAST141

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ku80 family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1471, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153239

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_394457_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9I7M8

Identification of Orthologs from Complete Genome Data

More...
OMAi
MASNKEC

Database of Orthologous Groups

More...
OrthoDBi
598957at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9I7M8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00873, KU80, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.240, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR024193, Ku80
IPR036494, Ku_C_sf
IPR005161, Ku_N
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02735, Ku, 1 hit
PF03731, Ku_N, 1 hit
PF08785, Ku_PK_bind, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016570, Ku80, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00559, Ku78, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 1 hit
SSF53300, SSF53300, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9I7M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNKECLII VLDVRTCAAE EVKLKSAKCV AEILKDKIVC DRKDYVSFVL
60 70 80 90 100
VGCDTDEIKT EDASHPNVLP FGEPRLCSWQ LLLEFFQFVN KTACEDGEWL
110 120 130 140 150
NGLQAALELQ NVATTLRVAR RRILLLFDFN DFPQDYEKFN EITDELLGEN
160 170 180 190 200
IELIVGTHNI AYIDNAITSQ PQAIFNFSRK CGPDELNNQK YALSLVPRCN
210 220 230 240 250
ATLCSFKEAL HTVFKVTNRR PWVWNAKLNI GSKISISLQG IIAMKNQTPV
260 270 280 290 300
KLVKVWAEKD EIVIRETRHY IKGTEITPLP ENLITGYMLG GTPVPYDEAV
310 320 330 340 350
LEPKEPHPPG LHFFGFIKRN AVPDEYFCGE SLYLLVHQKH NQSAAVKLDA
360 370 380 390 400
LVRALVSSDR AILCWKIYST KFNRPQMVVL LPRLADDTHP ATLYMLEVSY
410 420 430 440 450
TSQHHFWDFP ALRTTKTECS EEQLNAIDQL IDSTDLECTL RDTQQPRPWA
460 470 480 490 500
QNDLLPFDAL PSIFEQNVMD ILERKVIYDN DKEDKMLKDK NFADVFWRVP
510 520 530 540 550
DPLEEKSKRA AAIVKKLFPL RYSRAWQEKL LAKEQAENGV AVKSEPAEKE
560 570 580 590 600
IPLPSDGVGL IDPISDFRRV LASVHTISNA TERDARFQAL AADTRVVIIT
610 620 630 640 650
LLQRRKQNIG QLGELITLYR QSCIDFNTFL EYDKFAEELK KIALAKNRSE
660 670 680 690
FWQDVMVDKQ LGPLVLGEPT LDDELALKAY YTIENWVESG ANDMEDVEM
Length:699
Mass (Da):79,823
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EBCDBBED7BBB32B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAG22435.1

NCBI Reference Sequences

More...
RefSeqi
NP_609767.2, NM_135923.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080763; FBpp0080322; FBgn0041627

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34930

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG18801

UCSC genome browser

More...
UCSCi
CG18801-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAG22435.1
RefSeqiNP_609767.2, NM_135923.3

3D structure databases

SMRiQ9I7M8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9I7M8, 2 interactors
STRINGi7227.FBpp0080322

Proteomic databases

PaxDbiQ9I7M8
PRIDEiQ9I7M8

Genome annotation databases

EnsemblMetazoaiFBtr0080763; FBpp0080322; FBgn0041627
GeneIDi34930
KEGGidme:Dmel_CG18801
UCSCiCG18801-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34930
FlyBaseiFBgn0041627, Ku80
VEuPathDBiVectorBase:FBgn0041627

Phylogenomic databases

eggNOGiKOG1471, Eukaryota
GeneTreeiENSGT00940000153239
HOGENOMiCLU_394457_0_0_1
InParanoidiQ9I7M8
OMAiMASNKEC
OrthoDBi598957at2759
PhylomeDBiQ9I7M8

Enzyme and pathway databases

ReactomeiR-DME-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34930, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34930

Gene expression databases

BgeeiFBgn0041627, Expressed in testis and 31 other tissues
ExpressionAtlasiQ9I7M8, baseline and differential
GenevisibleiQ9I7M8, DM

Family and domain databases

CDDicd00873, KU80, 1 hit
Gene3Di1.25.40.240, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR024193, Ku80
IPR036494, Ku_C_sf
IPR005161, Ku_N
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF02735, Ku, 1 hit
PF03731, Ku_N, 1 hit
PF08785, Ku_PK_bind, 1 hit
PIRSFiPIRSF016570, Ku80, 1 hit
SMARTiView protein in SMART
SM00559, Ku78, 1 hit
SUPFAMiSSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 1 hit
SSF53300, SSF53300, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9I7M8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I7M8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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