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Entry version 175 (10 Feb 2021)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

Cell division cycle 23, isoform A

Gene

Cdc23

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, MitosisARBA annotation, Ubl conjugation pathwayARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174154, APC/C:Cdc20 mediated degradation of Securin
R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase
R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-DME-176412, Phosphorylation of the APC/C
R-DME-179409, APC-Cdc20 mediated degradation of Nek2A
R-DME-2467813, Separation of Sister Chromatids
R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cell division cycle 23, isoform AImported
Submitted name:
Cell division cycle 23, isoform BImported
Submitted name:
LD09850pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdc23Imported
Synonyms:38C.54Imported, APC8Imported, Apc8Imported, APC8 (cdc23)Imported, CDC23Imported, cdc23Imported, CG2508-PAImported, Dmel\CG2508Imported
ORF Names:CG2508Imported, Dmel_CG2508Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032863, Cdc23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032863, Expressed in imaginal disc and 17 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60670N

Protein interaction database and analysis system

More...
IntActi
Q9I7L8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080894

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini250 – 527TPR_REGIONInterPro annotationAdd BLAST278
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati250 – 283TPRPROSITE-ProRule annotationAdd BLAST34
Repeati318 – 351TPRPROSITE-ProRule annotationAdd BLAST34
Repeati352 – 385TPRPROSITE-ProRule annotationAdd BLAST34
Repeati386 – 419TPRPROSITE-ProRule annotationAdd BLAST34
Repeati420 – 453TPRPROSITE-ProRule annotationAdd BLAST34
Repeati494 – 527TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 567DisorderedSequence analysisAdd BLAST20
Regioni587 – 678DisorderedSequence analysisAdd BLAST92

Keywords - Domaini

RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1155, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018320_3_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYDRCAA

Database of Orthologous Groups

More...
OrthoDBi
761109at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007192, APC8
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04049, ANAPC8, 1 hit
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9I7L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMQKFFSVL LPDVKRELRR GIIECSKRGL LHSTKWLAEM HHGLADVHID
60 70 80 90 100
NEAPDEDRTF SECQLEGIAP EEYSDYFLAK SYYDVREYDR AAHAVRNCES
110 120 130 140 150
SVPRFLHFYS SYMAREKRRL DSTTDQANLH EPNQMRDLAD LLATLRMEYG
160 170 180 190 200
KSRLDGYGIY LYGVVLKALN LNQAAEQMLV QAIRLVPMLW SAYLELSPLI
210 220 230 240 250
MEKKKLLSLQ LGGHWMRHFF MAHTYLELYL NDDGLKIYED LQASGFSKSI
260 270 280 290 300
YLIAQMALVY HNKRDVDKAI ELYQALLESD PYRLDNVDTY SNLLFVKEMK
310 320 330 340 350
TEMAQLAHKA VSINKYRPET CCVIGNYYSI RCDHQVAISY FQRALKLNPK
360 370 380 390 400
YLAAWTLMGH EFMELKNTNA AIQSYRKAVE VNKRDYRAWY GLGQAYEIIK
410 420 430 440 450
MHYYSLYYFK IAHQLRPYDS RMLVALGETY EKLDKCENAV KCYWKAIDVG
460 470 480 490 500
DIEGIAMYKL ANLHEKLGDH ETAVHCYIMY CEDERAATDK QSLYQGFITL
510 520 530 540 550
ANYYEKKGEY ERAAYYAYKC LDSEDRKMEA KALLKTIDWK RNAEGQKKVK
560 570 580 590 600
TSTAVANADT SSEDEMEWEL QDVRVRVPIT SIATTTTSTT TVAAESASSS
610 620 630 640 650
SLISLRPDRN LIQGMRRSQS SRTSLTAPAS GTTTTPSATA VTMSTEETPG
660 670
TSGGPSNPPE QAPSDDNSSM EISSVSID
Length:678
Mass (Da):77,565
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i717BD0E0CEF93699
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAG22447.2
BT010078 mRNA Translation: AAQ22547.1
AE014134 Genomic DNA Translation: AGB93164.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260629.1, NM_001273700.1
NP_610036.2, NM_136192.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081362; FBpp0080894; FBgn0032863
FBtr0332969; FBpp0305185; FBgn0032863

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35315

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2508

UCSC genome browser

More...
UCSCi
CG2508-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAG22447.2
BT010078 mRNA Translation: AAQ22547.1
AE014134 Genomic DNA Translation: AGB93164.1
RefSeqiNP_001260629.1, NM_001273700.1
NP_610036.2, NM_136192.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-60670N
IntActiQ9I7L8, 1 interactor
STRINGi7227.FBpp0080894

Genome annotation databases

EnsemblMetazoaiFBtr0081362; FBpp0080894; FBgn0032863
FBtr0332969; FBpp0305185; FBgn0032863
GeneIDi35315
KEGGidme:Dmel_CG2508
UCSCiCG2508-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8697
FlyBaseiFBgn0032863, Cdc23

Phylogenomic databases

eggNOGiKOG1155, Eukaryota
GeneTreeiENSGT00950000182950
HOGENOMiCLU_018320_3_0_1
OMAiEYDRCAA
OrthoDBi761109at2759

Enzyme and pathway databases

ReactomeiR-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174154, APC/C:Cdc20 mediated degradation of Securin
R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase
R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-DME-176412, Phosphorylation of the APC/C
R-DME-179409, APC-Cdc20 mediated degradation of Nek2A
R-DME-2467813, Separation of Sister Chromatids
R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35315, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35315

Gene expression databases

BgeeiFBgn0032863, Expressed in imaginal disc and 17 other tissues

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR007192, APC8
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF04049, ANAPC8, 1 hit
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 3 hits
SMARTiView protein in SMART
SM00028, TPR, 8 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9I7L8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I7L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: October 1, 2002
Last modified: February 10, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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