UniProtKB - Q9I741 (VGR1A_PSEAE)
Protein
Type VI secretion system spike protein VgrG1a
Gene
vgrG1a
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 (PubMed:26894531). Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity (PubMed:30177742).4 Publications
GO - Biological processi
- protein secretion by the type VI secretion system Source: PseudoCAP
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-93-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Type VI secretion system spike protein VgrG1a1 PublicationAlternative name(s): T6SS spike protein VgrG1a |
Gene namesi | Name:vgrG1a1 Publication Ordered Locus Names:PA0091 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA0091 |
Subcellular locationi
- Secreted 1 Publication
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
- type VI protein secretion system complex Source: PseudoCAP
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000448911 | 1 – 643 | Type VI secretion system spike protein VgrG1aAdd BLAST | 643 |
Proteomic databases
PaxDbi | Q9I741 |
PRIDEi | Q9I741 |
Interactioni
Subunit structurei
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9I741 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the VgrG protein family.Curated
Phylogenomic databases
HOGENOMi | CLU_004121_3_0_6 |
InParanoidi | Q9I741 |
OMAi | NIARPHA |
PhylomeDBi | Q9I741 |
Family and domain databases
Gene3Di | 2.40.50.230, 1 hit |
InterProi | View protein in InterPro IPR006531, Gp5/Vgr_OB IPR017847, T6SS_RhsGE_Vgr_subset IPR006533, T6SS_Vgr_RhsGE IPR037026, Vgr_OB-fold_dom_sf |
Pfami | View protein in Pfam PF04717, Phage_base_V, 1 hit |
TIGRFAMsi | TIGR01646, vgr_GE, 1 hit TIGR03361, VI_Rhs_Vgr, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9I741-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLTRLVQVD CPLGPDVLLL QRMEGREELG RLFAYELHLV SENPNLPLEQ
60 70 80 90 100
LLGKPMSLSL ELPGGSRRFF HGIVARCSQV AGHGQFAGYQ ATLRPWPWLL
110 120 130 140 150
TRTSDCRIFQ NQSVPEIIKQ VFRNLGFSDF EDALTRPYRE WEYCVQYRET
160 170 180 190 200
SFDFISRLME QEGIYYWFRH EQKRHILVLS DAYGAHRSPG GYASVPYYPP
210 220 230 240 250
TLGHRERDHF FDWQMAREVQ PGSLTLNDYD FQRPGARLEV RSNIARPHAA
260 270 280 290 300
ADYPLYDYPG EYVQSQDGEQ YARNRIEAIQ AQHERVRLRG VVRGIGAGHL
310 320 330 340 350
FRLSGYPRDD QNREYLVVGA EYRVVQELYE TGSGGAGSQF ESELDCIDAS
360 370 380 390 400
QSFRLLPQTP VPVVRGPQTA VVVGPKGEEI WTDQYGRVKV HFHWDRHDQS
410 420 430 440 450
NENSSCWIRV SQAWAGKNWG SMQIPRIGQE VIVSFLEGDP DRPIITGRVY
460 470 480 490 500
NAEQTVPYEL PANATQSGMK SRSSKGGTPA NFNEIRMEDK KGAEQLYIHA
510 520 530 540 550
ERNQDNLVEN DASLSVGHDR NKSIGHDELA RIGNNRTRAV KLNDTLLVGG
560 570 580 590 600
AKSDSVTGTY LIEAGAQIRL VCGKSVVEFN ADGTINISGS AFNLYASGNG
610 620 630 640
NIDTGGRLDL NSGGASEVDA KGKGVQGTID GQVQAMFPPP AKG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG03481.1 |
PIRi | H83635 |
RefSeqi | NP_248781.1, NC_002516.2 WP_010895494.1, NZ_QZGE01000015.1 |
Genome annotation databases
EnsemblBacteriai | AAG03481; AAG03481; PA0091 |
GeneIDi | 879511 |
KEGGi | pae:PA0091 |
PATRICi | fig|208964.12.peg.95 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG03481.1 |
PIRi | H83635 |
RefSeqi | NP_248781.1, NC_002516.2 WP_010895494.1, NZ_QZGE01000015.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4MTK | X-ray | 3.32 | A/B/C/D/E/F | 1-643 | [»] | |
4UHV | X-ray | 2.00 | A/B | 1-643 | [»] | |
6H3L | electron microscopy | 4.20 | A/B/C | 1-643 | [»] | |
6H3N | electron microscopy | 3.25 | A/B/C | 1-643 | [»] | |
SMRi | Q9I741 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PaxDbi | Q9I741 |
PRIDEi | Q9I741 |
Genome annotation databases
EnsemblBacteriai | AAG03481; AAG03481; PA0091 |
GeneIDi | 879511 |
KEGGi | pae:PA0091 |
PATRICi | fig|208964.12.peg.95 |
Organism-specific databases
PseudoCAPi | PA0091 |
Phylogenomic databases
HOGENOMi | CLU_004121_3_0_6 |
InParanoidi | Q9I741 |
OMAi | NIARPHA |
PhylomeDBi | Q9I741 |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-93-MONOMER |
Family and domain databases
Gene3Di | 2.40.50.230, 1 hit |
InterProi | View protein in InterPro IPR006531, Gp5/Vgr_OB IPR017847, T6SS_RhsGE_Vgr_subset IPR006533, T6SS_Vgr_RhsGE IPR037026, Vgr_OB-fold_dom_sf |
Pfami | View protein in Pfam PF04717, Phage_base_V, 1 hit |
TIGRFAMsi | TIGR01646, vgr_GE, 1 hit TIGR03361, VI_Rhs_Vgr, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VGR1A_PSEAE | |
Accessioni | Q9I741Primary (citable) accession number: Q9I741 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2020 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families