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Entry version 84 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

Probable Resistance-Nodulation-Cell Division (RND) efflux transporter

Gene

PA0158

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell divisionImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-160-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.2.27 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Probable Resistance-Nodulation-Cell Division (RND) efflux transporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PA0158Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA0158

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 36HelicalSequence analysisAdd BLAST20
Transmembranei337 – 355HelicalSequence analysisAdd BLAST19
Transmembranei361 – 380HelicalSequence analysisAdd BLAST20
Transmembranei392 – 414HelicalSequence analysisAdd BLAST23
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei466 – 493HelicalSequence analysisAdd BLAST28
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Transmembranei882 – 901HelicalSequence analysisAdd BLAST20
Transmembranei907 – 931HelicalSequence analysisAdd BLAST25
Transmembranei958 – 977HelicalSequence analysisAdd BLAST20
Transmembranei983 – 1007HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9I6X4

PRoteomics IDEntifications database

More...
PRIDEi
Q9I6X4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9I6X4

KEGG Orthology (KO)

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KOi
K21134

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVWYLMF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9I6X4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9I6X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGGFNLSDW ALRHQSLVWY LMAVSLVMGV FSYLNLGREE DPSFAIKTMV
60 70 80 90 100
IQTRWPGATV DDTLEQVTDR IEKKLEELDS LDYVKSYTRP GESTVFVYLK
110 120 130 140 150
DTTKAGDIPD IWYQVRKKIS DIQGEFPQGI QGPGFNDEFG DVFGSVYAFT
160 170 180 190 200
ADGLDFRQLR DYVEKVRLDI RSVKDLGKVQ MIGAQNEVIY LNFSTRKLAA
210 220 230 240 250
LGLDQRQVVQ SLQAQNAVTP SGVVEAGPER ISVRTSGNFR SEKDLQAVNL
260 270 280 290 300
RVNDRFYRLS DLASISRDFV DPPTSLFRYK GEPAIGLAVA MKEGGNILEF
310 320 330 340 350
GEALNARMQE ITGELPVGVG VHQVSNQAQV VKKAVGGFTR ALFEAVVIVL
360 370 380 390 400
IVSFVSLGLR AGLVVACSIP LVLAMVFVFM EYTDITMQRV SLGALIIALG
410 420 430 440 450
LLVDDAMITV EMMITRLELG DSLHDSATYA YTSTAFPMLT GTLVTVAGFV
460 470 480 490 500
PIGLNASSAG EYTFTLFAVI AVALLLSWIV AVLFAPVIAV HILPKTLKHK
510 520 530 540 550
SEQKKGRIAE RFDSLLHLAM RRRWTTIFLT ALLFGVSLFL MKFVQHQFFP
560 570 580 590 600
SSDRPELLVD LNLPQNSSIH ETRAVMDRLE ATLKDDEDID HWSAYVGEGA
610 620 630 640 650
IRFYLPLDQQ LQNNFYGQLV IVTKDLEARE RVAARLRDRL RKDYVGISTY
660 670 680 690 700
VQPLEMGPPV GRPIQYRVSG PQIDKVREYA MGLAGVLDGN PNIGDIVYDW
710 720 730 740 750
NEPGKMLKID IAQDKARQLG LSSEDVAQIM NSVVTGSAVT QVRDDIYLVN
760 770 780 790 800
VIGRAEDSER GSLETLESLQ IVTPSGTSIP LKAFAKVSYE LEQPLVWRRD
810 820 830 840 850
RKPTITVKAS LRGEIQPTDL VARLAPEVKR FADGLPANYR IEVGGTVEES
860 870 880 890 900
GKAEGPIAKV VPLMLFLMAT FLMIQLQSVQ KLFLVASVAP LGLIGVVAAL
910 920 930 940 950
LPTGTPMGFV AILGILALIG IIIRNSVILV TQIDAFEKDG KTPWEAVLEA
960 970 980 990 1000
THHRTRPILL TAAAASLGMI PIAREVFWGP MAYAMIGGIV AATLLTLIFL
1010
PALYVAWYRI PEPGR
Length:1,015
Mass (Da):111,951
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CEA19AC01ADF191
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG03548.1

Protein sequence database of the Protein Information Resource

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PIRi
B83627

NCBI Reference Sequences

More...
RefSeqi
NP_248848.1, NC_002516.2
WP_003102199.1, NZ_QZGE01000015.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG03548; AAG03548; PA0158

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
882140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA0158

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|208964.12.peg.165

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG03548.1
PIRiB83627
RefSeqiNP_248848.1, NC_002516.2
WP_003102199.1, NZ_QZGE01000015.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.6.2.27 the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

PaxDbiQ9I6X4
PRIDEiQ9I6X4

Genome annotation databases

EnsemblBacteriaiAAG03548; AAG03548; PA0158
GeneIDi882140
KEGGipae:PA0158
PATRICifig|208964.12.peg.165

Organism-specific databases

PseudoCAPiPA0158

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
InParanoidiQ9I6X4
KOiK21134
OMAiFVWYLMF
PhylomeDBiQ9I6X4

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-160-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9I6X4_PSEAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I6X4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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