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Protein

3-carboxy-cis,cis-muconate cycloisomerase

Gene

pcaB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes an anti cycloisomerization.By similarity

Catalytic activityi

2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = cis,cis-butadiene-1,2,4-tricarboxylate.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-carboxy-cis,cis-muconate cycloisomerase (pcaB)
  2. no protein annotated in this organism
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-232-MONOMER
UniPathwayiUPA00157; UER00265

Names & Taxonomyi

Protein namesi
Recommended name:
3-carboxy-cis,cis-muconate cycloisomerase (EC:5.5.1.2)
Alternative name(s):
3-carboxymuconate lactonizing enzyme
Short name:
CMLE
Gene namesi
Name:pcaB
Ordered Locus Names:PA0230
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0230

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877721 – 4593-carboxy-cis,cis-muconate cycloisomeraseAdd BLAST459

Proteomic databases

PaxDbiQ9I6Q8
PRIDEiQ9I6Q8

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi208964.PA0230

Structurei

3D structure databases

ProteinModelPortaliQ9I6Q8
SMRiQ9I6Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family.Curated

Phylogenomic databases

eggNOGiENOG4107RAW Bacteria
COG0015 LUCA
InParanoidiQ9I6Q8
KOiK01857
OMAiHRATPMI
PhylomeDBiQ9I6Q8

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR019468 AdenyloSucc_lyase_C
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR012789 Protocat_PcaB
PfamiView protein in Pfam
PF10397 ADSL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SMARTiView protein in SMART
SM00998 ADSL_C, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR02426 protocat_pcaB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I6Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVPANQLF DAYFMAAPMR AVFSDRGRLQ GMLDFEAALA RAEARTGVVP
60 70 80 90 100
ATAVAPIEAA CRAELYDPLA LAEAVATAGN SAIPLVKALG RQVAAGDAEA
110 120 130 140 150
ERYVHLGATS QDAMDSGLVL QLRRALALLE QDLQRLAEVL ADQAERHADT
160 170 180 190 200
PLAGRTWLQH ATPVTLGMKL AGLLGALTRH RQRLRELRPR LLVLQFGGAS
210 220 230 240 250
GTLAALGEQA LPVAAALAEE LGLALPEQPW HTQRDRLVEF ASVLGLVAGS
260 270 280 290 300
LGKFGRDVSL LMQTEAGEVF EPAGAGRGGS STMPHKRNPV SSAVLIAAAT
310 320 330 340 350
RAPGLVSTLF AAMPQEHERS LGLWHAEWET LPELCCLVAG ALQQAIGLLE
360 370 380 390 400
GLEVDAQRMR RNLGLTHGLV LAEAVSIALA RRIGREAAHH LVEQCCRRAV
410 420 430 440 450
EQRRELRAVL GEEARVSAEL SGDELDRLLD PAHYLGQARA WVERALAEHH

ALGFEPHPA
Length:459
Mass (Da):49,121
Last modified:March 1, 2001 - v1
Checksum:iC43F6B3651F2D1D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG03619.1
PIRiB83616
RefSeqiNP_248921.1, NC_002516.2
WP_003112675.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG03619; AAG03619; PA0230
GeneIDi881957
KEGGipae:PA0230
PATRICifig|208964.12.peg.240

Similar proteinsi

Entry informationi

Entry nameiPCAB_PSEAE
AccessioniPrimary (citable) accession number: Q9I6Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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