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Protein

Membrane-bound lysozyme inhibitor of C-type lysozyme

Gene

mliC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically inhibits C-type lysozymes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei89Directly involved in lysozyme active site inhibition1 Publication1
Sitei103Directly involved in lysozyme active site inhibition1 Publication1

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-882-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lysozyme inhibitor of C-type lysozyme1 Publication
Gene namesi
Name:mliC1 Publication
Ordered Locus Names:PA0867
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0867

Subcellular locationi

  • Cell outer membrane By similarity; Lipid-anchor PROSITE-ProRule annotation
  • Note: Anchored to the periplasmic side.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi89S → A: Significantly reduced inhibitory activity. 1 Publication1
Mutagenesisi103K → A: Significantly reduced inhibitory activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18PROSITE-ProRule annotationAdd BLAST18
ChainiPRO_000037811019 – 127Membrane-bound lysozyme inhibitor of C-type lysozymeAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi19S-diacylglycerol cysteinePROSITE-ProRule annotation1
Disulfide bondi51 ↔ 1241 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9I574
PRIDEiQ9I574

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi208964.PA0867

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9I574
SMRiQ9I574
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9I574

Family & Domainsi

Sequence similaritiesi

Belongs to the MliC family. Type 2 subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41069B0 Bacteria
ENOG410Y0XP LUCA
InParanoidiQ9I574
OMAiWKGDRVI
PhylomeDBiQ9I574

Family and domain databases

Gene3Di2.40.128.200, 1 hit
InterProiView protein in InterPro
IPR018660 MliC
IPR036328 MliC_sf
PfamiView protein in Pfam
PF09864 MliC, 1 hit
SUPFAMiSSF141488 SSF141488, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9I574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKALWLLLA AVPVVLVACG GSDDDKQTAQ VDYLALPGDA KLDTRSVDYK
60 70 80 90 100
CENGRKFTVQ YLNKGDNSLA VVPVSDNSTL VFSNVISASG AKYAAGQYIW
110 120
WTKGEEATLY GDWKGGEPTD GVACKER
Length:127
Mass (Da):13,695
Last modified:March 1, 2001 - v1
Checksum:i70DDB95ABB6371AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04256.1
PIRiH83537
RefSeqiNP_249558.1, NC_002516.2
WP_003085889.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04256; AAG04256; PA0867
GeneIDi882238
KEGGipae:PA0867
PATRICifig|208964.12.peg.901

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04256.1
PIRiH83537
RefSeqiNP_249558.1, NC_002516.2
WP_003085889.1, NC_002516.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F6ZX-ray2.50B/D29-127[»]
ProteinModelPortaliQ9I574
SMRiQ9I574
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0867

Proteomic databases

PaxDbiQ9I574
PRIDEiQ9I574

Protocols and materials databases

DNASUi882238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04256; AAG04256; PA0867
GeneIDi882238
KEGGipae:PA0867
PATRICifig|208964.12.peg.901

Organism-specific databases

PseudoCAPiPA0867

Phylogenomic databases

eggNOGiENOG41069B0 Bacteria
ENOG410Y0XP LUCA
InParanoidiQ9I574
OMAiWKGDRVI
PhylomeDBiQ9I574

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-882-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ9I574

Family and domain databases

Gene3Di2.40.128.200, 1 hit
InterProiView protein in InterPro
IPR018660 MliC
IPR036328 MliC_sf
PfamiView protein in Pfam
PF09864 MliC, 1 hit
SUPFAMiSSF141488 SSF141488, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMLIC_PSEAE
AccessioniPrimary (citable) accession number: Q9I574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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