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Protein

Thiol:disulfide interchange protein DsbE

Gene

dsbE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1507-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbE
Alternative name(s):
Cytochrome c biogenesis protein CcmG
Gene namesi
Name:dsbE
Synonyms:ccmG
Ordered Locus Names:PA1481
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1481

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 180PeriplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012981 – 180Thiol:disulfide interchange protein DsbEAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 77Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9I3N1

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1481

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 30Combined sources3
Turni32 – 37Combined sources6
Beta strandi44 – 49Combined sources6
Beta strandi53 – 56Combined sources4
Helixi57 – 60Combined sources4
Beta strandi65 – 70Combined sources6
Helixi75 – 89Combined sources15
Beta strandi93 – 100Combined sources8
Helixi103 – 112Combined sources10
Beta strandi118 – 123Combined sources6
Helixi127 – 132Combined sources6
Beta strandi139 – 143Combined sources5
Beta strandi148 – 155Combined sources8
Helixi159 – 165Combined sources7
Helixi167 – 174Combined sources8

3D structure databases

ProteinModelPortaliQ9I3N1
SMRiQ9I3N1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9I3N1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 175ThioredoxinPROSITE-ProRule annotationAdd BLAST142

Sequence similaritiesi

Belongs to the thioredoxin family. DsbE subfamily.Curated

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QX9 Bacteria
COG0526 LUCA
HOGENOMiHOG000097218
InParanoidiQ9I3N1
KOiK02199
OMAiKWLAEFH
PhylomeDBiQ9I3N1

Family and domain databases

CDDicd03010 TlpA_like_DsbE, 1 hit
InterProiView protein in InterPro
IPR004799 Periplasmic_diS_OxRdtase_DsbE
IPR013740 Redoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF08534 Redoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00385 dsbE, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9I3N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAILLLPL GIFLIVAVFL FRGLWLDPSE LPSALIGKPF PAFDLPSVQD
60 70 80 90 100
PARRLTEADL KGKPALVNVW GTWCPSCRVE HPELTRLAEQ GVVIYGINYK
110 120 130 140 150
DDNAAAIKWL NELHNPYLLS ISDADGTLGL DLGVYGAPET YLIDKQGIIR
160 170 180
HKIVGVVDQK VWREQLAPLY QQLLDEPEAR
Length:180
Mass (Da):20,122
Last modified:March 1, 2001 - v1
Checksum:i6C85E368106673F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG04870.1
PIRiB83460
RefSeqiNP_250172.1, NC_002516.2
WP_003083138.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04870; AAG04870; PA1481
GeneIDi881065
KEGGipae:PA1481
PATRICifig|208964.12.peg.1532

Similar proteinsi

Entry informationi

Entry nameiDSBE_PSEAE
AccessioniPrimary (citable) accession number: Q9I3N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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