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Entry version 91 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

Probable Resistance-Nodulation-Cell Division (RND) efflux transporter

Gene

PA2526

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell divisionImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-2561-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.2.39 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Probable Resistance-Nodulation-Cell Division (RND) efflux transporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PA2526Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA2526

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei338 – 355HelicalSequence analysisAdd BLAST18
Transmembranei362 – 381HelicalSequence analysisAdd BLAST20
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei465 – 489HelicalSequence analysisAdd BLAST25
Transmembranei859 – 876HelicalSequence analysisAdd BLAST18
Transmembranei896 – 922HelicalSequence analysisAdd BLAST27
Transmembranei959 – 977HelicalSequence analysisAdd BLAST19
Transmembranei989 – 1013HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9I0V7

PRoteomics IDEntifications database

More...
PRIDEi
Q9I0V7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9I0V7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158127

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9I0V7

KEGG Orthology (KO)

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KOi
K07789

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMDRSPV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9I0V7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9I0V7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSTPFIRR PVATTLLTLA LLLAGTLSFG LLPVAPLPNV DFPAIVVSAS
60 70 80 90 100
LPGASPETMA SSVATPLERS LGRIAGISEM TSSSSLGSTT VVLVFDLEKD
110 120 130 140 150
IDGAAREVQA AINGAMSLLP SGMPNNPSYR KANPSDMPIM VLTLTSETQS
160 170 180 190 200
RGEMYDLAST VLAPKLSQVQ GVGQVSIGGS SLPAVRVDLN PDAMSQYGLS
210 220 230 240 250
LDSVRTAIAA ANSNGPKGAV EKDDKHWQVD ANDQLRKARE YEPLVIHYNA
260 270 280 290 300
DNGAAVRLGD VAKVSDSVED VRNAGFSDDL PAVLLIVTRQ PGANIIEATD
310 320 330 340 350
AIHAQLPVLQ ELLGPQVKLN VMDDRSPSIR ASLEEAELTL LISVALVILV
360 370 380 390 400
VFLFLRNGRA TLIPSLAVPV SLIGTFAVMY LCDFSLNNLS LMALIIATGF
410 420 430 440 450
VVDDAIVVVE NIARRIEEGD PPIQAAITGA RQVGFTVLSM TLSLVAVFIP
460 470 480 490 500
LLLMGGLTGR LFREFAVTLS AAILVSLVVS LTLTPMLCAR LLRPLKRPEG
510 520 530 540 550
ASLARRSDRF FAAFMLRYRA SLGWALEHSR LMVVIMLACI AMNLWLFVVV
560 570 580 590 600
PKGFLPQQDS GRLRGYAVAD QSISFQSLSA KMGEYRKILS SDPAVENVVG
610 620 630 640 650
FIGGGRWQSS NTGSFFVTLK PIGERDPVEK VLTRLRERIA KVPGAALYLN
660 670 680 690 700
AGQDVRLGGR DSNAQYEFTL RSDDLTLLRE WAPKVEAAMR KLPQLVDVNS
710 720 730 740 750
DSQDKGVQTR LVIDRDRAAT LGINVEMVDA VLNDSFGQRQ VSTIFNPLNQ
760 770 780 790 800
YRVVMEVDQQ YQQSPEILRQ VQVIGNDGQR VPLSAFSHYE PSRAPLEVNH
810 820 830 840 850
QGQFAATTLS FNLAPGAQIG PTREAIMQAL EPLHIPVDVQ TSFEGNAGAV
860 870 880 890 900
QDTQNQMPWL ILLALLAVYI VLGILYESYV HPLTILSTLP SAGVGALLAL
910 920 930 940 950
ILCRSELSLI ALIGIILLIG IVKKNAIMMI DFALEAERNH GLSPREAILE
960 970 980 990 1000
ACMMRFRPIM MTTLAALLGA LPLIFGIGGD AALRRPLGIT IVGGLIGSQL
1010 1020 1030
LTLYTTPVVY LYLDRLRHWV NQKRGVRTDG ALETPL
Length:1,036
Mass (Da):111,830
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4E3581856F2169E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG05914.1

Protein sequence database of the Protein Information Resource

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PIRi
G83329

NCBI Reference Sequences

More...
RefSeqi
NP_251216.1, NC_002516.2
WP_003089914.1, NZ_QZGE01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG05914; AAG05914; PA2526

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
882888

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA2526

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.2641

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG05914.1
PIRiG83329
RefSeqiNP_251216.1, NC_002516.2
WP_003089914.1, NZ_QZGE01000008.1

3D structure databases

SMRiQ9I0V7
ModBaseiSearch...

Protein family/group databases

TCDBi2.A.6.2.39 the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

PaxDbiQ9I0V7
PRIDEiQ9I0V7

Genome annotation databases

EnsemblBacteriaiAAG05914; AAG05914; PA2526
GeneIDi882888
KEGGipae:PA2526
PATRICifig|208964.12.peg.2641

Organism-specific databases

PseudoCAPiPA2526

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158127
InParanoidiQ9I0V7
KOiK07789
OMAiAMDRSPV
PhylomeDBiQ9I0V7

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-2561-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9I0V7_PSEAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9I0V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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