nuoG

Functionⁱ

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityⁱ

NADH + a quinone = NAD⁺ + a quinol.

Cofactorⁱ

Protein has several cofactor binding sites:

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
[4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	34	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	45	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	48	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	67	Iron-sulfur 1 (2Fe-2S)By similarity	1
Metal bindingⁱ	99	Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation	1
Metal bindingⁱ	103	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	106	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	112	Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation	1
Metal bindingⁱ	151	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	154	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	157	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	201	Iron-sulfur 3 (4Fe-4S)By similarity	1
Metal bindingⁱ	228	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	231	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	235	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1
Metal bindingⁱ	263	Iron-sulfur 4 (4Fe-4S)Sequence analysis	1

GO - Molecular functionⁱ

2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
4 iron, 4 sulfur cluster binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
electron transfer activity Source: InterPro
metal ion binding Source: UniProtKB-KW
NADH dehydrogenase (ubiquinone) activity Source: InterPro
quinone binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP synthesis coupled electron transport Source: InterPro
cellular respiration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCycⁱ	PAER208964:G1FZ6-2682-MONOMER

BioCycⁱ

PAER208964:G1FZ6-2682-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH-quinone oxidoreductase subunit G (EC:1.6.5.11) Alternative name(s): NADH dehydrogenase I subunit G NDH-1 subunit G
Gene namesⁱ	Name:nuoG Ordered Locus Names:PA2642
Organismⁱ	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifierⁱ	208964 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa
Proteomesⁱ	UP000002438 Componentⁱ: Chromosome

Organism-specific databases

Pseudomonas genome database More...PseudoCAPⁱ	PA2642

PseudoCAPⁱ

PA2642

Subcellular locationⁱ

GO - Cellular componentⁱ

plasma membrane respiratory chain complex I
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118549	1 – 905	NADH-quinone oxidoreductase subunit GAdd BLAST		905

Keywords - PTMⁱ

Quinone

Proteomic databases

PaxDbⁱ	Q9I0J6
PRIDEⁱ	Q9I0J6

Interactionⁱ

Subunit structureⁱ

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

STRINGⁱ	208964.PA2642

STRINGⁱ

208964.PA2642

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9I0J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 83	2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST	83
Domainⁱ	83 – 122	4Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	221 – 277	4Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST	57

Sequence similaritiesⁱ

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4108IEH Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
InParanoidⁱ	Q9I0J6
KEGG Orthology (KO) More...KOⁱ	K00336
OMAⁱ	GYGYVNR
PhylomeDBⁱ	Q9I0J6

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR009010 Asp_de-COase-like_dom_sf IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF50692 SSF50692, 1 hit SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9I0J6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATIHVDGKT LEVDGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV 
        60         70         80         90        100
KQYTDENDKR GRLVMSCMTP ATDNTWISIE DEEAKQFRAS VVEWLMTNHP 
       110        120        130        140        150
HDCPVCEEGG HCHLQDMTVM TGHNERRYRF TKRTHQNQEL GPFIAHEMNR 
       160        170        180        190        200
CIACYRCVRY YKDYAGGTDL GVYGAHDNVY FGRVEDGVLE SEFSGNLTEV 
       210        220        230        240        250
CPTGVFTDKT HSERYNRKWD MQFAPSICHG CSSGCNISPG ERYGEIRRIE 
       260        270        280        290        300
NRYNGSVNHY FLCDRGRFGY GYVNREDRPR QPLLVLSKQK LSLDGALDQA 
       310        320        330        340        350
AALLKERKVV GIGSPRASLE SNFALRELVG EGNFYSGINE GELDRLRLIL 
       360        370        380        390        400
QVMQEGPLPV PSIRDIEDHD AVFVLGEDLT QTAARIALAL RQSVKGKAVE 
       410        420        430        440        450
MAADMKVQPW LDAAVKNIAQ HAQNPLFIAS VSATRLDDVA EETVHAAPDD 
       460        470        480        490        500
LARLGFAVAH AIDPSAPSVA DLDPQAQAFA QRITDALLAA KRPLVVSGNS 
       510        520        530        540        550
LGNKALIEAA ANIAKALKQR EKNGSISLVV GEANSLGLAL FGGDSVEAAL 
       560        570        580        590        600
ERLTSGQADA VVVLENDLYR RTDAARVDAA LAAAKVVIVA DHQQTATTAK 
       610        620        630        640        650
AHLVLPAASF AEGDGTLVSQ EGRAQRFFQV FDPTYYDARN MVREGWRWLH 
       660        670        680        690        700
AIHSTLQGKR VDWTQLDHVT EAVAEAKPIL AGIRDAAPAA SFRIKGLKLA 
       710        720        730        740        750
REPHRYSGRT AMRANISVHE PRTPQDIDSA FAFSMEGYSG SQEDRQQIPF 
       760        770        780        790        800
AWSPGWNSPQ AWNKFQDEVG GHLRAGDPGV RLIEPKGEGL DWFQAVPVPF 
       810        820        830        840        850
SAKADSWKVV PLYHLFGSEE NSSRAAPIQQ RIPETYVALS KEDADRLGVN 
       860        870        880        890        900
DGATLGFQLK GQALRLPLRI DEQLGAGLIG LPVGFAGIPA AIAGCSVEGL 

QEAAQ

Length:905

Mass (Da):99,000

Last modified:March 1, 2001 - v1

Checksum:ⁱ775E4CD402A8F311

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE004091 Genomic DNA Translation: AAG06030.1
PIRⁱ	G83314
NCBI Reference Sequences More...RefSeqⁱ	NP_251332.1, NC_002516.2 WP_003113377.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaⁱ	AAG06030; AAG06030; PA2642
GeneIDⁱ	882349
KEGGⁱ	pae:PA2642
PATRICⁱ	fig\|208964.12.peg.2765

Protein	Similar proteins		Species	Score	Length	Source
Q9I0J6	NADH dehydrogenase (Quinone) subunit G (Fragment)		PSEAI		391	UniRef100_Q9I0J6
NADH-quinone oxidoreductase subunit G (Fragment)		PSEAI		202
NADH-quinone oxidoreductase subunit G (Fragment)		PSEAI		219
NADH-quinone oxidoreductase subunit G (Fragment)		PSEAI		113
NADH-quinone oxidoreductase subunit G (Fragment)		PSEAI		260
+6

Protein	Similar proteins		Species	Score	Length	Source
Q9I0J6	NADH dehydrogenase (Quinone) subunit G (Fragment)		PSEAI		391	UniRef90_Q9I0J6
NADH-quinone oxidoreductase		ACIBA		905
NADH-quinone oxidoreductase		Pseudomonas sp. HMSC059F05		905
NADH-quinone oxidoreductase		Pseudomonas sp. RW410		905
NADH-quinone oxidoreductase		Pseudomonas aeruginosa MH27		905
+135

Protein	Similar proteins		Species	Score	Length	Source
Q9I0J6	NADH-quinone oxidoreductase subunit G		ECOLI		908	UniRef50_P33602
NADH-quinone oxidoreductase subunit G		SHIFL		908
NADH-quinone oxidoreductase subunit G		ECO57		908
NADH-quinone oxidoreductase subunit G		ECOL6		908
NADH-quinone oxidoreductase subunit G		SALTI		908
+4739

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE004091 Genomic DNA Translation: AAG06030.1
PIRⁱ	G83314
RefSeqⁱ	NP_251332.1, NC_002516.2 WP_003113377.1, NC_002516.2

3D structure databases

ProteinModelPortalⁱ	Q9I0J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	208964.PA2642

STRINGⁱ

208964.PA2642

Proteomic databases

PaxDbⁱ	Q9I0J6
PRIDEⁱ	Q9I0J6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAG06030; AAG06030; PA2642
GeneIDⁱ	882349
KEGGⁱ	pae:PA2642
PATRICⁱ	fig\|208964.12.peg.2765

Organism-specific databases

PseudoCAPⁱ	PA2642

PseudoCAPⁱ

PA2642

Phylogenomic databases

eggNOGⁱ	ENOG4108IEH Bacteria COG1034 LUCA
HOGENOMⁱ	HOG000276177
InParanoidⁱ	Q9I0J6
KOⁱ	K00336
OMAⁱ	GYGYVNR
PhylomeDBⁱ	Q9I0J6

Enzyme and pathway databases

BioCycⁱ	PAER208964:G1FZ6-2682-MONOMER

BioCycⁱ

PAER208964:G1FZ6-2682-MONOMER

Family and domain databases

CDDⁱ	cd00207 fer2, 1 hit
InterProⁱ	View protein in InterPro IPR036010 2Fe-2S_ferredoxin-like_sf IPR001041 2Fe-2S_ferredoxin-type IPR009010 Asp_de-COase-like_dom_sf IPR006656 Mopterin_OxRdtase IPR006963 Mopterin_OxRdtase_4Fe-4S_dom IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228 NADH_UbQ_OxRdtase_Gsu IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
Pfamⁱ	View protein in Pfam PF04879 Molybdop_Fe4S4, 1 hit PF00384 Molybdopterin, 1 hit PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTⁱ	View protein in SMART SM00926 Molybdop_Fe4S4, 1 hit SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMⁱ	SSF50692 SSF50692, 1 hit SSF54292 SSF54292, 1 hit
TIGRFAMsⁱ	TIGR01973 NuoG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51085 2FE2S_FER_2, 1 hit PS51839 4FE4S_HC3, 1 hit PS51669 4FE4S_MOW_BIS_MGD, 1 hit PS00641 COMPLEX1_75K_1, 1 hit PS00642 COMPLEX1_75K_2, 1 hit PS00643 COMPLEX1_75K_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUOG_PSEAE
Accessionⁱ	Q9I0J6Primary (citable) accession number: Q9I0J6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9I0J6 (NUOG_PSEAE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

NADH-quinone oxidoreductase subunit G

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ