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Entry version 86 (10 Apr 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Aerobic cobaltochelatase subunit CobN

Gene

cobN

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes cobalt insertion in the corrin ring.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 10 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route).
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. Precorrin-2 C(20)-methyltransferase (cobI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Precorrin-4 C(11)-methyltransferase (cobM)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (cobL)
  8. Precorrin-8X methylmutase (cobH)
  9. Hydrogenobyrinate a,c-diamide synthase (cobB)
  10. Aerobic cobaltochelatase subunit CobN (cobN)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-2995-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00148;UER00221

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aerobic cobaltochelatase subunit CobN (EC:6.6.1.2)
Alternative name(s):
Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cobN
Ordered Locus Names:PA2944
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA2944

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002877871 – 1248Aerobic cobaltochelatase subunit CobNAdd BLAST1248

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HZQ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9HZQ3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of CobN, CobS and CobT.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HZQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CobN family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CTK Bacteria
COG1429 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000225033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HZQ3

KEGG Orthology (KO)

More...
KOi
K02230

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWALHGI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HZQ3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011953 Cobalto_CobN
IPR003672 CobN/Mg_chltase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02514 CobN-Mg_chel, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02257 cobalto_cobN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HZQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLRTQPGG FVPDDGIAHL AQTPAELVIL CSGDSHLALL AEAARALPDD
60 70 80 90 100
YPSLRLANPM QLQNHASVDL YVEEVLRHAR VILLSLHGGI GYWRYGVEQL
110 120 130 140 150
VALAERGALL IPVPGDDRPD PELSALGNLP AEQAERFWQY LRQGGLENAG
160 170 180 190 200
QFYRCLASQC LGRDYAWREP QALPRVALFH PRHAEATLEH WRADWQAGRP
210 220 230 240 250
VVALLFYRTH LQAANTAFIA RFCERLAAQG LNPLPIALAS LKESACLAQV
260 270 280 290 300
EDWLERSDAA LIVNTTGFAQ SNPEAPELRP FRRDVPVLQA ICSLDNRPLW
310 320 330 340 350
LDNPQGLGPR DLAMHVALPE LDGRIVTRPI SFKGLAWRSE RSESDVVCYL
360 370 380 390 400
ADDERMDFVA ELARRWAELA RKPNAEKRVA LVLANYPTRD GRIGNGVGLD
410 420 430 440 450
TPAAALNILR ALRQQGYPVD GLPASGTELI RQLLGGVSND LEHLDLRPCA
460 470 480 490 500
QSLALDDYLA CFARLPERNR QAVLARWGEP QQDPMFRDGR MMVAGLRYGL
510 520 530 540 550
TFVGIQPARG YQLDPAAVYH DPDLVPPHGY LAFYFWLRHA YRADALLHVG
560 570 580 590 600
KHGNLEWLPG KGVGLSAECW PDALLGPLPN IYPFIVNDPG EGAQAKRRTQ
610 620 630 640 650
AVIIDHLMPP LTRAESYGPL RDLERLADEF YDASLLDPRR AEQLRGEILV
660 670 680 690 700
LLRDNRLDRE IGLQLSDDPD SWLPQLDAYL CDLKESQIRD GLHVFGESPS
710 720 730 740 750
GRLRLDTLLA LLRVPRGDGK GANAGLLKSL ADDLGLGFDP LACDMGEAWQ
760 770 780 790 800
GARPACLEER GGEPWRTLGD TRERLELLAL HWIERCLGGE SPPATWRASG
810 820 830 840 850
EVLRGLCEQV APTLDACGGA EIDGLLAALE GRFVPAGPSG APSRGRLDVL
860 870 880 890 900
PTGRNFFSVD VRNLPTPTAW RIGFQSANLL LERHLQEHGD HLRQLGLSVW
910 920 930 940 950
GTATMRTGGD DIAQALALLG VRPVWQAGSQ RVADFEILPV SLLDRPRVDV
960 970 980 990 1000
TLRVSGFFRD AFANLIRLFD AAVQAVAELD EAEELNPLAA RVRLERQRLE
1010 1020 1030 1040 1050
AQGTAPAEAR RQAGWRIFGA KPGAYGAGVQ GAIEERLWET RADLAEVYLN
1060 1070 1080 1090 1100
WGGYAYGAAD DGTPARERFA QRLERLQAVL HNQDNREHDL LDSNDYYQFQ
1110 1120 1130 1140 1150
GGMLAAVETL RGAPVASYHG DHSQPDNPRI RTLKEELNRV VRARAVNPKW
1160 1170 1180 1190 1200
IAGMKRHGYK GAFELAATVD YLCAFDATSE LIDDHQYALL ADAYLLDAET
1210 1220 1230 1240
REFVRQHNPQ ALRDMAERLV EAQRRGLWQE PGAYREALEN LLLDVEEE
Length:1,248
Mass (Da):138,501
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3D3DBFEE6736C7A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG06332.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G83278

NCBI Reference Sequences

More...
RefSeqi
NP_251634.1, NC_002516.2
WP_003113999.1, NZ_QZGE01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG06332; AAG06332; PA2944

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
882831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA2944

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.3088

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG06332.1
PIRiG83278
RefSeqiNP_251634.1, NC_002516.2
WP_003113999.1, NZ_QZGE01000009.1

3D structure databases

SMRiQ9HZQ3
ModBaseiSearch...

Proteomic databases

PaxDbiQ9HZQ3
PRIDEiQ9HZQ3

Genome annotation databases

EnsemblBacteriaiAAG06332; AAG06332; PA2944
GeneIDi882831
KEGGipae:PA2944
PATRICifig|208964.12.peg.3088

Organism-specific databases

PseudoCAPiPA2944

Phylogenomic databases

eggNOGiENOG4105CTK Bacteria
COG1429 LUCA
HOGENOMiHOG000225033
InParanoidiQ9HZQ3
KOiK02230
OMAiPWALHGI
PhylomeDBiQ9HZQ3

Enzyme and pathway databases

UniPathwayiUPA00148;UER00221
BioCyciPAER208964:G1FZ6-2995-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR011953 Cobalto_CobN
IPR003672 CobN/Mg_chltase
PfamiView protein in Pfam
PF02514 CobN-Mg_chel, 1 hit
TIGRFAMsiTIGR02257 cobalto_cobN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOBN_PSEAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HZQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: April 10, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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