UniProtKB - Q9HZN8 (KTHY_PSEAE)
Protein
Thymidylate kinase
Gene
tmk
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity
Catalytic activityi
- EC:2.7.4.9
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- thymidylate kinase activity Source: GO_Central
- uridylate kinase activity Source: GO_Central
GO - Biological processi
- dTDP biosynthetic process Source: GO_Central
- dTTP biosynthetic process Source: GO_Central
- dUDP biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Nucleotide biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-3014-MONOMER |
BRENDAi | 2.7.4.9, 5087 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tmk Ordered Locus Names:PA2962 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA2962 |
Subcellular locationi
GO - Cellular componenti
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155324 | 1 – 210 | Thymidylate kinaseAdd BLAST | 210 |
Proteomic databases
PaxDbi | Q9HZN8 |
PRIDEi | Q9HZN8 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9HZN8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidylate kinase family.Curated
Phylogenomic databases
HOGENOMi | CLU_049131_0_2_6 |
InParanoidi | Q9HZN8 |
OMAi | VMTREPG |
PhylomeDBi | Q9HZN8 |
Family and domain databases
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HZN8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGLFVTLEG PEGAGKSTNR DYLAERLRER GIEVQLTREP GGTPLAERIR
60 70 80 90 100
ELLLAPSDEP MAADTELLLM FAARAQHLAG VIRPALARGA VVLCDRFTDA
110 120 130 140 150
TYAYQGGGRG LPEARIAALE SFVQGDLRPD LTLVFDLPVE IGLARAAARG
160 170 180 190 200
RLDRFEQEDR RFFEAVRQTY LQRAAQAPER YQVLDAGLPL AEVQAGLDRL
210
LPNLLERLNG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG06350.1 |
PIRi | E83275 |
RefSeqi | NP_251652.1, NC_002516.2 WP_003091125.1, NZ_QZGE01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAG06350; AAG06350; PA2962 |
GeneIDi | 878730 |
KEGGi | pae:PA2962 |
PATRICi | fig|208964.12.peg.3108 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG06350.1 |
PIRi | E83275 |
RefSeqi | NP_251652.1, NC_002516.2 WP_003091125.1, NZ_QZGE01000009.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UWK | X-ray | 1.91 | A/B | 1-210 | [»] | |
3UWO | X-ray | 1.70 | A/B | 1-210 | [»] | |
3UXM | X-ray | 1.95 | A/B/C/D | 2-210 | [»] | |
4E5U | X-ray | 1.81 | A/B | 1-210 | [»] | |
4EDH | X-ray | 1.32 | A/B | 1-210 | [»] | |
4ESH | X-ray | 1.95 | A | 1-210 | [»] | |
4GMD | X-ray | 1.98 | A/B/C/D | 1-210 | [»] | |
SMRi | Q9HZN8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PaxDbi | Q9HZN8 |
PRIDEi | Q9HZN8 |
Protocols and materials databases
DNASUi | 878730 |
Genome annotation databases
EnsemblBacteriai | AAG06350; AAG06350; PA2962 |
GeneIDi | 878730 |
KEGGi | pae:PA2962 |
PATRICi | fig|208964.12.peg.3108 |
Organism-specific databases
PseudoCAPi | PA2962 |
Phylogenomic databases
HOGENOMi | CLU_049131_0_2_6 |
InParanoidi | Q9HZN8 |
OMAi | VMTREPG |
PhylomeDBi | Q9HZN8 |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-3014-MONOMER |
BRENDAi | 2.7.4.9, 5087 |
Family and domain databases
HAMAPi | MF_00165, Thymidylate_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR039430, Thymidylate_kin-like_dom IPR018094, Thymidylate_kinase |
Pfami | View protein in Pfam PF02223, Thymidylate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00041, DTMP_kinase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KTHY_PSEAE | |
Accessioni | Q9HZN8Primary (citable) accession number: Q9HZN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families