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UniProtKB - Q9HZ67 (CMPDT_PSEAE)
Protein
Bifunctional chorismate mutase/prephenate dehydratase
Gene
pheA
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
By similarityCatalytic activityi
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.By similarity This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: prephenate biosynthesis
This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.By similarity This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 11 | SubstrateBy similarity | 1 | |
Binding sitei | 28 | SubstrateBy similarity | 1 | |
Binding sitei | 39 | SubstrateBy similarity | 1 | |
Binding sitei | 57 | SubstrateBy similarity | 1 | |
Sitei | 265 | Essential for prephenate dehydratase activitySequence analysis | 1 |
GO - Molecular functioni
- chorismate mutase activity Source: UniProtKB-EC
- prephenate dehydratase activity Source: GO_Central
GO - Biological processi
- chorismate metabolic process Source: InterPro
- L-phenylalanine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Isomerase, Lyase, Multifunctional enzyme |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
SABIO-RKi | Q9HZ67 |
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Bifunctional chorismate mutase/prephenate dehydrataseBy similarityAlternative name(s): Chorismate mutase-prephenate dehydrataseBy similarity P-proteinBy similarity Including the following 2 domains: |
Gene namesi | Name:pheA Ordered Locus Names:PA3166 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA3166 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287803 | 1 – 365 | Bifunctional chorismate mutase/prephenate dehydrataseAdd BLAST | 365 |
Proteomic databases
PaxDbi | Q9HZ67 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 96 | Chorismate mutasePROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 97 – 272 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 284 – 361 | ACTPROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
HOGENOMi | CLU_035008_0_1_6 |
InParanoidi | Q9HZ67 |
OMAi | PLMIYRE |
PhylomeDBi | Q9HZ67 |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR010957, G/b/e-P-prot_chorismate_mutase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit SSF55021, SSF55021, 1 hit |
TIGRFAMsi | TIGR01807, CM_P2, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HZ67-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADQDQLKAL RLRIDSLDEK LLELISERAR CAQDVARVKT QTLGEGEAPV
60 70 80 90 100
FYRPEREAWV LKHIMQLNKG PLDNEEVARL FREIMSSCLA LEQPLKVAYL
110 120 130 140 150
GPEGTFTQAA ALKHFGNAVI STPMAAIDEV FREVAAGAVN FGVVPVENST
160 170 180 190 200
EGAVNHTLDS FLEHDMVICG EVELRIHHHL LVGETTKTDN ITRIYSHAQS
210 220 230 240 250
LAQCRKWLDS HYPSVERVAV SSNADAAKRV KSEWNSAAIA GDMAASLYDL
260 270 280 290 300
SKLHEKIEDR PDNSTRFLII GNQEVPPTGD DKTSIIVSMR NKPGALHELL
310 320 330 340 350
VPFHNNGIDL TRIETRPSRS GKWTYVFFID FVGHHKEPLI KDVLEKIGQE
360
AVALKVLGSY PKAVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG06554.1 |
PIRi | G83250 |
RefSeqi | NP_251856.1, NC_002516.2 WP_003091446.1, NZ_QZGE01000023.1 |
Genome annotation databases
EnsemblBacteriai | AAG06554; AAG06554; PA3166 |
GeneIDi | 882699 |
KEGGi | pae:PA3166 |
PATRICi | fig|208964.12.peg.3309 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG06554.1 |
PIRi | G83250 |
RefSeqi | NP_251856.1, NC_002516.2 WP_003091446.1, NZ_QZGE01000023.1 |
3D structure databases
SMRi | Q9HZ67 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 287.DR97_4770 |
Proteomic databases
PaxDbi | Q9HZ67 |
Protocols and materials databases
DNASUi | 882699 |
Genome annotation databases
EnsemblBacteriai | AAG06554; AAG06554; PA3166 |
GeneIDi | 882699 |
KEGGi | pae:PA3166 |
PATRICi | fig|208964.12.peg.3309 |
Organism-specific databases
PseudoCAPi | PA3166 |
Phylogenomic databases
HOGENOMi | CLU_035008_0_1_6 |
InParanoidi | Q9HZ67 |
OMAi | PLMIYRE |
PhylomeDBi | Q9HZ67 |
Enzyme and pathway databases
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
SABIO-RKi | Q9HZ67 |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR010957, G/b/e-P-prot_chorismate_mutase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit SSF55021, SSF55021, 1 hit |
TIGRFAMsi | TIGR01807, CM_P2, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CMPDT_PSEAE | |
Accessioni | Q9HZ67Primary (citable) accession number: Q9HZ67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways