UniProtKB - Q9HXH7 (Q9HXH7_PSEAE)
Protein
Cyclic-guanylate-specific phosphodiesterase
Gene
PA3825
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Catalytic activityi
- EC:3.1.4.52ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 279 | Cyclic diguanosine monophosphateCombined sources | 1 | |
Metal bindingi | 293 | Calcium 1Combined sources | 1 | |
Metal bindingi | 293 | Magnesium 1Combined sources | 1 | |
Metal bindingi | 294 | Magnesium 2; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 307 | Cyclic diguanosine monophosphateCombined sources | 1 | |
Metal bindingi | 352 | Calcium 1Combined sources | 1 | |
Metal bindingi | 352 | Calcium 2Combined sources | 1 | |
Metal bindingi | 352 | Magnesium 1Combined sources | 1 | |
Binding sitei | 352 | Cyclic diguanosine monophosphateCombined sources | 1 | |
Metal bindingi | 353 | Calcium 2; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 353 | Calcium 3; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 384 | Calcium 1Combined sources | 1 | |
Metal bindingi | 384 | Magnesium 1Combined sources | 1 | |
Metal bindingi | 389 | Calcium 2Combined sources | 1 | |
Metal bindingi | 389 | Calcium 3Combined sources | 1 | |
Metal bindingi | 414 | Calcium 1Combined sources | 1 | |
Metal bindingi | 414 | Calcium 4Combined sources | 1 | |
Metal bindingi | 414 | Magnesium 1Combined sources | 1 | |
Metal bindingi | 415 | Calcium 4Combined sources | 1 | |
Metal bindingi | 415 | Calcium 5Combined sources | 1 | |
Metal bindingi | 437 | Calcium 5Combined sources | 1 | |
Binding sitei | 438 | Cyclic diguanosine monophosphateCombined sources | 1 | |
Metal bindingi | 471 | Calcium 4Combined sources | 1 | |
Metal bindingi | 471 | Calcium 5Combined sources | 1 | |
Binding sitei | 493 | Cyclic diguanosine monophosphateCombined sources | 1 | |
Binding sitei | 497 | Cyclic diguanosine monophosphateCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 293 – 297 | Cyclic diguanosine monophosphateCombined sources | 5 | |
Nucleotide bindingi | 414 – 415 | Cyclic diguanosine monophosphateCombined sources | 2 | |
Nucleotide bindingi | 472 – 474 | Cyclic diguanosine monophosphateCombined sources | 3 |
GO - Molecular functioni
- cyclic-guanylate-specific phosphodiesterase activity Source: PseudoCAP
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseARBA annotation |
Ligand | c-di-GMPARBA annotation, CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-3897-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic-guanylate-specific phosphodiesteraseARBA annotation (EC:3.1.4.52ARBA annotation) |
Gene namesi | Ordered Locus Names:PA3825Imported |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA3825 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 35 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 258 – 512 | EALInterPro annotationAdd BLAST | 255 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_000445_131_0_6 |
InParanoidi | Q9HXH7 |
OMAi | IRFISQR |
PhylomeDBi | Q9HXH7 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HXH7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIPVKRARR KALRLSLSVL VGVMPIVLGL LILYWQAERS LQETSEQAAG
60 70 80 90 100
NAVRQFERML DNAALAARKV MPVAGRPCPE AELALREQVA IMPFVRSVNL
110 120 130 140 150
TRDNTIYCTS LFGGFDEPVR IENYVDGRLL LMPGNQVTPD AALLVLRDFD
160 170 180 190 200
GKRGVLAAID GRYLSYVLDL VDRRSRQVLV VGPNWLDAEG RTHRDAPPTY
210 220 230 240 250
EVAAVSLASQ RYPLRVLSGF PEGEEWRSIR SQNPAMFGLL LFFGLLAGTL
260 270 280 290 300
CYWLSRRVAS PSSELRRALE ANEFIPYYQP LSPGQGGRWI GVEVLMRWRH
310 320 330 340 350
PREGLIRPDL FIPFAERSGL IVPMTRALMR QVAEDLGGHA GKLEPGFHIG
360 370 380 390 400
FNISATHCHE LALVDDCREL LAAFPPGHIT LVLELTEREL IESSEVTDRL
410 420 430 440 450
FDELHALGVK IAIDDFGTGH SSLAYLRKFQ VDCLKIDQSF VARIGIDTLS
460 470 480 490 500
GHILDSIVEL SAKLDLDIVA EGVETPEQRD YLAARGVDYL QGYLIGRPMP
510 520
LESLLSSLTV QEGQGASVVA LPADRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG07212.1 |
PIRi | F83166 |
RefSeqi | NP_252514.1, NC_002516.2 WP_003119288.1, NZ_QZGE01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAG07212; AAG07212; PA3825 |
GeneIDi | 879846 |
KEGGi | pae:PA3825 |
PATRICi | fig|208964.12.peg.4005 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG07212.1 |
PIRi | F83166 |
RefSeqi | NP_252514.1, NC_002516.2 WP_003119288.1, NZ_QZGE01000001.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Y8E | X-ray | 1.61 | A/B | 255-517 | [»] | |
4Y9M | X-ray | 1.60 | A | 255-517 | [»] | |
4Y9N | X-ray | 1.92 | A | 255-517 | [»] | |
4Y9O | X-ray | 1.81 | A | 255-517 | [»] | |
4Y9P | X-ray | 2.44 | A/B | 255-517 | [»] | |
5MF5 | X-ray | 1.77 | A | 259-514 | [»] | |
5MFU | X-ray | 2.15 | A | 259-512 | [»] | |
SMRi | Q9HXH7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PaxDbi | Q9HXH7 |
Genome annotation databases
EnsemblBacteriai | AAG07212; AAG07212; PA3825 |
GeneIDi | 879846 |
KEGGi | pae:PA3825 |
PATRICi | fig|208964.12.peg.4005 |
Organism-specific databases
PseudoCAPi | PA3825 |
Phylogenomic databases
HOGENOMi | CLU_000445_131_0_6 |
InParanoidi | Q9HXH7 |
OMAi | IRFISQR |
PhylomeDBi | Q9HXH7 |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-3897-MONOMER |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR024744, CSS-motif_dom IPR001633, EAL_dom IPR035919, EAL_sf |
Pfami | View protein in Pfam PF12792, CSS-motif, 1 hit PF00563, EAL, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9HXH7_PSEAE | |
Accessioni | Q9HXH7Primary (citable) accession number: Q9HXH7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |