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Entry version 97 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Cyclic-guanylate-specific phosphodiesterase

Gene

PA3825

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei279Cyclic diguanosine monophosphateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi293Calcium 1Combined sources1
Metal bindingi293Magnesium 1Combined sources1
Metal bindingi294Magnesium 2; via carbonyl oxygenCombined sources1
Binding sitei307Cyclic diguanosine monophosphateCombined sources1
Metal bindingi352Calcium 1Combined sources1
Metal bindingi352Calcium 2Combined sources1
Metal bindingi352Magnesium 1Combined sources1
Binding sitei352Cyclic diguanosine monophosphateCombined sources1
Metal bindingi353Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi353Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi384Calcium 1Combined sources1
Metal bindingi384Magnesium 1Combined sources1
Metal bindingi389Calcium 2Combined sources1
Metal bindingi389Calcium 3Combined sources1
Metal bindingi414Calcium 1Combined sources1
Metal bindingi414Calcium 4Combined sources1
Metal bindingi414Magnesium 1Combined sources1
Metal bindingi415Calcium 4Combined sources1
Metal bindingi415Calcium 5Combined sources1
Metal bindingi437Calcium 5Combined sources1
Binding sitei438Cyclic diguanosine monophosphateCombined sources1
Metal bindingi471Calcium 4Combined sources1
Metal bindingi471Calcium 5Combined sources1
Binding sitei493Cyclic diguanosine monophosphateCombined sources1
Binding sitei497Cyclic diguanosine monophosphateCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi293 – 297Cyclic diguanosine monophosphateCombined sources5
Nucleotide bindingi414 – 415Cyclic diguanosine monophosphateCombined sources2
Nucleotide bindingi472 – 474Cyclic diguanosine monophosphateCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
Ligandc-di-GMPARBA annotation, CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-3897-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic-guanylate-specific phosphodiesteraseARBA annotation (EC:3.1.4.52ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PA3825Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA3825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 35HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HXH7

PRoteomics IDEntifications database

More...
PRIDEi
Q9HXH7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HXH7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini258 – 512EALInterPro annotationAdd BLAST255

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_131_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HXH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRFISQR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HXH7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01948, EAL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.450, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024744, CSS-motif_dom
IPR001633, EAL_dom
IPR035919, EAL_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12792, CSS-motif, 1 hit
PF00563, EAL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00052, EAL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141868, SSF141868, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50883, EAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HXH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIPVKRARR KALRLSLSVL VGVMPIVLGL LILYWQAERS LQETSEQAAG
60 70 80 90 100
NAVRQFERML DNAALAARKV MPVAGRPCPE AELALREQVA IMPFVRSVNL
110 120 130 140 150
TRDNTIYCTS LFGGFDEPVR IENYVDGRLL LMPGNQVTPD AALLVLRDFD
160 170 180 190 200
GKRGVLAAID GRYLSYVLDL VDRRSRQVLV VGPNWLDAEG RTHRDAPPTY
210 220 230 240 250
EVAAVSLASQ RYPLRVLSGF PEGEEWRSIR SQNPAMFGLL LFFGLLAGTL
260 270 280 290 300
CYWLSRRVAS PSSELRRALE ANEFIPYYQP LSPGQGGRWI GVEVLMRWRH
310 320 330 340 350
PREGLIRPDL FIPFAERSGL IVPMTRALMR QVAEDLGGHA GKLEPGFHIG
360 370 380 390 400
FNISATHCHE LALVDDCREL LAAFPPGHIT LVLELTEREL IESSEVTDRL
410 420 430 440 450
FDELHALGVK IAIDDFGTGH SSLAYLRKFQ VDCLKIDQSF VARIGIDTLS
460 470 480 490 500
GHILDSIVEL SAKLDLDIVA EGVETPEQRD YLAARGVDYL QGYLIGRPMP
510 520
LESLLSSLTV QEGQGASVVA LPADRG
Length:526
Mass (Da):58,309
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFC7C0A95B7B32B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07212.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F83166

NCBI Reference Sequences

More...
RefSeqi
NP_252514.1, NC_002516.2
WP_003119288.1, NZ_QZGE01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG07212; AAG07212; PA3825

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
879846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA3825

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.4005

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07212.1
PIRiF83166
RefSeqiNP_252514.1, NC_002516.2
WP_003119288.1, NZ_QZGE01000001.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y8EX-ray1.61A/B255-517[»]
4Y9MX-ray1.60A255-517[»]
4Y9NX-ray1.92A255-517[»]
4Y9OX-ray1.81A255-517[»]
4Y9PX-ray2.44A/B255-517[»]
5MF5X-ray1.77A259-514[»]
5MFUX-ray2.15A259-512[»]
SMRiQ9HXH7
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PaxDbiQ9HXH7
PRIDEiQ9HXH7

Genome annotation databases

EnsemblBacteriaiAAG07212; AAG07212; PA3825
GeneIDi879846
KEGGipae:PA3825
PATRICifig|208964.12.peg.4005

Organism-specific databases

PseudoCAPiPA3825

Phylogenomic databases

HOGENOMiCLU_000445_131_0_6
InParanoidiQ9HXH7
OMAiIRFISQR
PhylomeDBiQ9HXH7

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3897-MONOMER

Family and domain databases

CDDicd01948, EAL, 1 hit
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR024744, CSS-motif_dom
IPR001633, EAL_dom
IPR035919, EAL_sf
PfamiView protein in Pfam
PF12792, CSS-motif, 1 hit
PF00563, EAL, 1 hit
SMARTiView protein in SMART
SM00052, EAL, 1 hit
SUPFAMiSSF141868, SSF141868, 1 hit
PROSITEiView protein in PROSITE
PS50883, EAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9HXH7_PSEAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HXH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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