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Entry version 98 (26 Feb 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Nuclease SbcCD subunit C

Gene

sbcC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi37 – 44ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA recombination, DNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-4366-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclease SbcCD subunit C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sbcC
Ordered Locus Names:PA4282
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA4282

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001058661 – 1211Nuclease SbcCD subunit CAdd BLAST1211

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HWB8

PRoteomics IDEntifications database

More...
PRIDEi
Q9HWB8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of SbcC and SbcD.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HWB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili115 – 156Sequence analysisAdd BLAST42
Coiled coili197 – 407Sequence analysisAdd BLAST211
Coiled coili497 – 584Sequence analysisAdd BLAST88
Coiled coili628 – 1048Sequence analysisAdd BLAST421

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. SbcC subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EYH Bacteria
COG0419 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004785_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HWB8

KEGG Orthology (KO)

More...
KOi
K03546

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLQEAHI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HWB8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HWB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILAIRLKN LASLAGEQEI DFTREPLSSA GLFAITGPTG AGKSTVLDAL
60 70 80 90 100
CLALFGSTPR LESTSASSKV PDGRNELSSN DERNLLRRGC ASGYAEVDFV
110 120 130 140 150
GIDGHRYRAR WETRRSRDKA DGALQKSQQS LQDLETQQML AANKKSEFRE
160 170 180 190 200
QLEQKLGLNF AQFTRAVLLA QSEFSAFLKA SDNDRGALLE KLTDTGLYSQ
210 220 230 240 250
LSKAAYQRAS QADEQRKQLE QRLEGSLPLA EQARAGLEAA LESHAQARLQ
260 270 280 290 300
EQQALQRLEG QQQWFTEEQR LLQSCEHAQG QLAEARQAWD ALATERETLQ
310 320 330 340 350
WLERLAPVRG LIERLKQLEQ ELRHSEQQQR QRTEQQAAGT ERLQGLQARL
360 370 380 390 400
QEARERQAQA DNHLRQAQAP LREAFQLESE ARRLERTLAE RQELHRQSNQ
410 420 430 440 450
RHAQQSDAAR QLDMEQQRHV AEQAQLQAAL RDSQALAALG DAWVTHQGQL
460 470 480 490 500
ATFVQRRQRA LESQAQLPEL EKSLAHAGEP LERLQAQWTA LHGSEPDDLA
510 520 530 540 550
ARLVELRRQT DSLERQQALH KEWQQVLDQR AGLARRLGEL DQRMVEQEQA
560 570 580 590 600
LLDLKRQGSQ CAEEVKAAEQ ALQVTRELLQ RQRLARSASV EQLRAGLVDG
610 620 630 640 650
EACPVCGSQE HPYHHSEQLL AALGEHDDQE QVRAEQSLER LRQTLVGLRE
660 670 680 690 700
GYSSQRERLN QSRQEQQELT GQLAALDRQL DQWTLPEELR LLQPSAQLEW
710 720 730 740 750
LAQRLDDLAG QRQQCQRDFD RLIARQRQTQ QLQQELRAAE TILQQRQQAL
760 770 780 790 800
TEQRQRYEHL QQQVEEDSQQ LRPLLSDEHW QRWQADPLRT FQALGESIEQ
810 820 830 840 850
RRQQQARLQQ IEQRLQELKQ RCDESSWQLK QSDEQRNEAR QAEERAQAEL
860 870 880 890 900
AELNGRLGAH LGQHACAQDW QLSLEHAAQA AQSAVETLQA PLDSLREEQL
910 920 930 940 950
RLAEALEHLQ QQRQRQQDEF QRLQADWQAW RERQDNLDDS RLDALLGLSE
960 970 980 990 1000
EQATQWREQL QRLQEEITRQ QTLEAERQAQ LLQHRRQRPE TDREALEDNL
1010 1020 1030 1040 1050
RQQRERLAAS EQAYLETYSQ LQADNQRREQ SQALLAELER ARAEFRRWGR
1060 1070 1080 1090 1100
LNELIGSSSG DKFRRIAQGY NLDLLVQHSN VQLRQLARRY RLQRGGSELG
1110 1120 1130 1140 1150
LLVVDTEMGD ELRSVYSLSG GETFLISLAL ALGLASMASS KLRIESLFID
1160 1170 1180 1190 1200
EGFGSLDPES LQLAMDALDN LQAQGRKVAV ISHVQEMHER IPVQVRVQRE
1210
GNGMSSLKVV G
Length:1,211
Mass (Da):138,960
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC8DCA6656C08E42
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07670.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C83110

NCBI Reference Sequences

More...
RefSeqi
NP_252972.1, NC_002516.2
WP_003114994.1, NZ_QZGE01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG07670; AAG07670; PA4282

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
881690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA4282

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.4484

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG07670.1
PIRiC83110
RefSeqiNP_252972.1, NC_002516.2
WP_003114994.1, NZ_QZGE01000034.1

3D structure databases

SMRiQ9HWB8
ModBaseiSearch...

Proteomic databases

PaxDbiQ9HWB8
PRIDEiQ9HWB8

Genome annotation databases

EnsemblBacteriaiAAG07670; AAG07670; PA4282
GeneIDi881690
KEGGipae:PA4282
PATRICifig|208964.12.peg.4484

Organism-specific databases

PseudoCAPiPA4282

Phylogenomic databases

eggNOGiENOG4105EYH Bacteria
COG0419 LUCA
HOGENOMiCLU_004785_1_1_6
InParanoidiQ9HWB8
KOiK03546
OMAiSLQEAHI
PhylomeDBiQ9HWB8

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4366-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSBCC_PSEAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HWB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 1, 2001
Last modified: February 26, 2020
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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