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UniProtKB - Q9HV74 (Q9HV74_PSEAE)

Entry version 144 (25 May 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Histidine kinase

Gene

cbrA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.ARBA annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.21.9.1, the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseARBA annotation (EC:2.7.13.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cbrAImported
Ordered Locus Names:PA4725Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...PseudoCAPi		PA4725

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei48 – 67HelicalSequence analysisAdd BLAST20
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei114 – 135HelicalSequence analysisAdd BLAST22
Transmembranei155 – 173HelicalSequence analysisAdd BLAST19
Transmembranei185 – 209HelicalSequence analysisAdd BLAST25
Transmembranei244 – 263HelicalSequence analysisAdd BLAST20
Transmembranei275 – 298HelicalSequence analysisAdd BLAST24
Transmembranei322 – 355HelicalSequence analysisAdd BLAST34
Transmembranei376 – 394HelicalSequence analysisAdd BLAST19
Transmembranei400 – 422HelicalSequence analysisAdd BLAST23
Transmembranei429 – 451HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:3440

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HV74

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		287.DR97_2068

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9HV74

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HV74

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini630 – 674PASInterPro annotationAdd BLAST45
Domaini763 – 977Histidine kinaseInterPro annotationAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni958 – 983DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000445_22_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HV74

Identification of Orthologs from Complete Genome Data

More...OMAi		IVMPHMY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HV74

Family and domain databases

Conserved Domains Database

More...CDDi		cd00082, HisKA, 1 hit
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1730.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR004358, Sig_transdc_His_kin-like_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00989, PAS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00344, BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47384, SSF47384, 1 hit
SSF55785, SSF55785, 1 hit
SSF55874, SSF55874, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50109, HIS_KIN, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HV74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTSFSLTQL ILISVTYLST LFGIAWITER GYVPRRLVRH PLVYTLSLGV 
        60         70         80         90        100
YASAWAFYGT VGLAYQYGYG FLAIYLGISG AFLLAPVLLY PILRVTRAYQ 
       110        120        130        140        150
LSSLADLFAF RFRSTWAGAL TTLFMLIGVL PMLALQIQAV TDSISILTRD 
       160        170        180        190        200
PAQERVAFVF CTLITLFAIL FGARHIATRE RHEGLVFAIA FESLVKLVML 
       210        220        230        240        250
GSIGLYALYG VFGGPEGLEV WLLQNQTALT TLHTPLAEGP WRTLLLVFFA 
       260        270        280        290        300
AAIVMPHMFH MIFTENLNPR ALISASWGLP LFLLLMSLAV PPILWAGLRL 
       310        320        330        340        350
GASTTPEYYT IGLGLAVDSP ALALAAFIGG ISAASGLTIV MTLALSGMVL 
       360        370        380        390        400
NHLVLPLYQP PAQGNIYRWL KWTRRLLIVA IIMASYAFYL LLGAEQDLSN 
       410        420        430        440        450
LGIVSFVATL QFLPGALSVL YWPTANRRGF ISGLIAGMLV WAITMLLPLM 
       460        470        480        490        500
GNVQGLYLPL FDVIYVLDDS NWHLAALSSL AANVLVFTLV SLFTEASDEE 
       510        520        530        540        550
KGAAEACAVD NVRRPQRREL FAGSPQEFAS QLAKPLGAKT AQKEVEQALR 
       560        570        580        590        600
DLHLPFDERR PYALRRLRDR IEANLSGLMG PSVAQDIVET FLPYKTSEES 
       610        620        630        640        650
YVTEDIHFIE SRLEDYHSRL TGLAAELDTL RRYHRQTLQD LPMGVCSLAK 
       660        670        680        690        700
DQEVLMWNRA IEELTGVGAQ KVVGSRLSAL PEPWKGLLER FIDAPDEHLH 
       710        720        730        740        750
KQRLVYDGHT RWLNLHKAAI EEPLAPGNSG LVLLVEDLTE TQLLEDKLVH 
       760        770        780        790        800
SERLASIGRL AAGVAHEIGN PITGIACLAQ NLREEREGDG ELTEISEQIL 
       810        820        830        840        850
DQTKRVSRIV QSLMSFAHSG SHLQALEPVC LSEVAQEAIG LLSLNRRSVE 
       860        870        880        890        900
VEFFNLCDPA HWVEGDSQRL AQVLINLLSN ARDASPPGGA IRVRSEASEH 
       910        920        930        940        950
TVDLVVEDEG SGIPKAIMDQ LFEPFFTTKD PGKGTGLGLA LVYSIVEEHY 
       960        970        980 
GQITIESPTD HQREGGTRFR VTLPRHPGPT AEL
Length:983
Mass (Da):108,381
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3089981E0773D70
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08111.1

Protein sequence database of the Protein Information Resource

More...PIRi		B83055

NCBI Reference Sequences

More...RefSeqi		NP_253413.1, NC_002516.2
WP_003113915.1, NZ_QZGE01000018.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAG08111; AAG08111; PA4725

Database of genes from NCBI RefSeq genomes

More...GeneIDi		881602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pae:PA4725

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|208964.12.peg.4950

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08111.1
PIRiB83055
RefSeqiNP_253413.1, NC_002516.2
WP_003113915.1, NZ_QZGE01000018.1

3D structure databases

AlphaFoldDBiQ9HV74
SMRiQ9HV74
ModBaseiSearch...

Protein-protein interaction databases

STRINGi287.DR97_2068

Protein family/group databases

TCDBi2.A.21.9.1, the solute:sodium symporter (sss) family

Proteomic databases

PaxDbiQ9HV74

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		881602

Genome annotation databases

EnsemblBacteriaiAAG08111; AAG08111; PA4725
GeneIDi881602
KEGGipae:PA4725
PATRICifig|208964.12.peg.4950

Organism-specific databases

PseudoCAPiPA4725

Phylogenomic databases

HOGENOMiCLU_000445_22_1_6
InParanoidiQ9HV74
OMAiIVMPHMY
PhylomeDBiQ9HV74

Miscellaneous databases

PHI-baseiPHI:3440

Family and domain databases

CDDicd00082, HisKA, 1 hit
cd00130, PAS, 1 hit
Gene3Di1.20.1730.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR003661, HisK_dim/P
IPR036097, HisK_dim/P_sf
IPR038377, Na/Glc_symporter_sf
IPR001734, Na/solute_symporter
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR004358, Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF02518, HATPase_c, 1 hit
PF00512, HisKA, 1 hit
PF00989, PAS, 1 hit
PRINTSiPR00344, BCTRLSENSOR
SMARTiView protein in SMART
SM00387, HATPase_c, 1 hit
SM00388, HisKA, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF47384, SSF47384, 1 hit
SSF55785, SSF55785, 1 hit
SSF55874, SSF55874, 1 hit
TIGRFAMsiTIGR00229, sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50109, HIS_KIN, 1 hit
PS50283, NA_SOLUT_SYMP_3, 1 hit
PS50112, PAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9HV74_PSEAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HV74
Secondary accession number(s): Q7DID2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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