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Protein

RNA-binding protein Hfq

Gene

hfq

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.UniRule annotation

GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

  • pathogenesis Source: PseudoCAP
  • quorum sensing Source: PseudoCAP
  • regulation of carbon utilization Source: PseudoCAP
  • regulation of RNA stability Source: PseudoCAP
  • regulation of transcription, DNA-templated Source: InterPro
  • regulation of translation Source: PseudoCAP
  • regulation of translation, ncRNA-mediated Source: PseudoCAP

Keywordsi

Molecular functionRNA-binding
Biological processStress response

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5060-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein HfqUniRule annotation
Gene namesi
Name:hfqUniRule annotation
Ordered Locus Names:PA4944
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4944

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000956561 – 82RNA-binding protein HfqAdd BLAST82

Proteomic databases

PaxDbiQ9HUM0
PRIDEiQ9HUM0

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA4944

Structurei

Secondary structure

182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HUM0
SMRiQ9HUM0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HUM0

Family & Domainsi

Sequence similaritiesi

Belongs to the Hfq family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KW8 Bacteria
COG1923 LUCA
HOGENOMiHOG000004931
InParanoidiQ9HUM0
KOiK03666
OMAiQQMVYKH
PhylomeDBiQ9HUM0

Family and domain databases

CDDicd01716 Hfq, 1 hit
HAMAPiMF_00436 Hfq, 1 hit
InterProiView protein in InterPro
IPR005001 Hfq
IPR010920 LSM_dom_sf
PANTHERiPTHR34772 PTHR34772, 1 hit
PfamiView protein in Pfam
PF17209 Hfq, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
TIGRFAMsiTIGR02383 Hfq, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HUM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKGHSLQDP YLNTLRKERV PVSIYLVNGI KLQGQIESFD QFVILLKNTV
60 70 80
SQMVYKHAIS TVVPSRPVRL PSGDQPAEPG NA
Length:82
Mass (Da):9,104
Last modified:March 1, 2001 - v1
Checksum:i1153661DC4C5AE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08329.1
PIRiD83028
RefSeqiNP_253631.1, NC_002516.2
WP_003095657.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG08329; AAG08329; PA4944
GeneIDi34029102
878015
KEGGipae:PA4944
PATRICifig|208964.12.peg.5177

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG08329.1
PIRiD83028
RefSeqiNP_253631.1, NC_002516.2
WP_003095657.1, NC_002516.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U1SX-ray1.60A/B/C/D/E/F1-82[»]
1U1TX-ray1.90A/B/C/D/E/F1-82[»]
3INZX-ray1.70A/B/C/D/E/F1-82[»]
3M4GX-ray2.05A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
3QUIX-ray1.93A/B/C/D/E/F1-82[»]
4J5YX-ray2.10A/B/C/D/E/F1-82[»]
4J6WX-ray1.80A/B/C/D/E/F1-82[»]
4J6XX-ray2.22A/B/C/D/E/F1-82[»]
4J6YX-ray2.14A/B/C/D/E/F1-82[»]
4MMKX-ray2.16A/B/C/D/E/F/G/H/I/J/K/L1-82[»]
4MMLX-ray1.80A1-82[»]
ProteinModelPortaliQ9HUM0
SMRiQ9HUM0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4944

Proteomic databases

PaxDbiQ9HUM0
PRIDEiQ9HUM0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08329; AAG08329; PA4944
GeneIDi34029102
878015
KEGGipae:PA4944
PATRICifig|208964.12.peg.5177

Organism-specific databases

PseudoCAPiPA4944

Phylogenomic databases

eggNOGiENOG4105KW8 Bacteria
COG1923 LUCA
HOGENOMiHOG000004931
InParanoidiQ9HUM0
KOiK03666
OMAiQQMVYKH
PhylomeDBiQ9HUM0

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5060-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ9HUM0

Family and domain databases

CDDicd01716 Hfq, 1 hit
HAMAPiMF_00436 Hfq, 1 hit
InterProiView protein in InterPro
IPR005001 Hfq
IPR010920 LSM_dom_sf
PANTHERiPTHR34772 PTHR34772, 1 hit
PfamiView protein in Pfam
PF17209 Hfq, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
TIGRFAMsiTIGR02383 Hfq, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHFQ_PSEAE
AccessioniPrimary (citable) accession number: Q9HUM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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