UniProtKB - Q9HTE3 (FADH_PSEAE)
Protein
Glutathione-independent formaldehyde dehydrogenase
Gene
fdhA
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Catalyzes the NAD+-dependent oxidation of formaldehyde and acetoaldehyde.By similarity
Catalytic activityi
- EC:1.2.1.46By similarity
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 47 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 68 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 98 | Zinc 2By similarity | 1 | |
Metal bindingi | 101 | Zinc 2By similarity | 1 | |
Metal bindingi | 104 | Zinc 2By similarity | 1 | |
Metal bindingi | 112 | Zinc 2By similarity | 1 | |
Metal bindingi | 177 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- formaldehyde dehydrogenase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-5548-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione-independent formaldehyde dehydrogenase (EC:1.2.1.46)Short name: FALDH Short name: FDH |
Gene namesi | Name:fdhA Ordered Locus Names:PA5421 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA5421 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000287742 | 2 – 399 | Glutathione-independent formaldehyde dehydrogenaseAdd BLAST | 398 |
Proteomic databases
PaxDbi | Q9HTE3 |
Interactioni
Subunit structurei
Homotetramer.
By similarityFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 172 – 338 | Cofactor-bindingAdd BLAST | 167 |
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_026673_11_3_6 |
InParanoidi | Q9HTE3 |
OMAi | VAMGPYQ |
PhylomeDBi | Q9HTE3 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR007698, AlaDH/PNT_NAD(H)-bd IPR011032, GroES-like_sf IPR014184, HCHO_DH_non_GSH IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF01262, AlaDh_PNT_C, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02819, fdhA_non_GSH, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9HTE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGNRGVVYL GPGKVEVQNI PYPKMQDPQG RQIDHGVILR VVSTNICGSD
60 70 80 90 100
QHMVRGRTTA PEGLVLGHEI TGEVVEIGRG VETMKIGDLV SVPFNVACGH
110 120 130 140 150
CRTCKEQHTG VCLTVNPARA GGAYGYVDMG GWVGGQAEYV LVPYADFNLL
160 170 180 190 200
KLPNREAAME KIRDLTCLSD ILPTGYHGAV TAGVGPGSTV YIAGAGPVGL
210 220 230 240 250
AAAASARLLG AAVVIVGDVN PTRLAHAKKQ GFEIADLSKD TPLHEQIAAL
260 270 280 290 300
LGEPEVDCAV DAVGFEARGH GHSGSQQEAP ATVLNSLMGI TRVAGKIGIP
310 320 330 340 350
GLYVTEDPGA VDAAAKHGAL SIRFGLGWAK SHSFHTGQTP VMKYNRQLMQ
360 370 380 390
AIMWDRIKIA DIVGVEVITL DDAPKGYGEF DAGVPKKFVI DPHNLFRAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG08806.1 |
PIRi | E82969 |
RefSeqi | NP_254108.1, NC_002516.2 WP_003096788.1, NZ_QZGE01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAG08806; AAG08806; PA5421 |
GeneIDi | 880053 |
KEGGi | pae:PA5421 |
PATRICi | fig|208964.12.peg.5681 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004091 Genomic DNA Translation: AAG08806.1 |
PIRi | E82969 |
RefSeqi | NP_254108.1, NC_002516.2 WP_003096788.1, NZ_QZGE01000012.1 |
3D structure databases
SMRi | Q9HTE3 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q9HTE3 |
Genome annotation databases
EnsemblBacteriai | AAG08806; AAG08806; PA5421 |
GeneIDi | 880053 |
KEGGi | pae:PA5421 |
PATRICi | fig|208964.12.peg.5681 |
Organism-specific databases
PseudoCAPi | PA5421 |
Phylogenomic databases
HOGENOMi | CLU_026673_11_3_6 |
InParanoidi | Q9HTE3 |
OMAi | VAMGPYQ |
PhylomeDBi | Q9HTE3 |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-5548-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR007698, AlaDH/PNT_NAD(H)-bd IPR011032, GroES-like_sf IPR014184, HCHO_DH_non_GSH IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF01262, AlaDh_PNT_C, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02819, fdhA_non_GSH, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FADH_PSEAE | |
Accessioni | Q9HTE3Primary (citable) accession number: Q9HTE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families